{"id":"https://openalex.org/W1970724952","doi":"https://doi.org/10.1016/0014-5793(95)00884-c","title":"HPV 16 E7 oncoprotein induces expression of a 110 kDa heat shock protein","display_name":"HPV 16 E7 oncoprotein induces expression of a 110 kDa heat shock protein","publication_year":1995,"publication_date":"1995-09-11","ids":{"openalex":"https://openalex.org/W1970724952","doi":"https://doi.org/10.1016/0014-5793(95)00884-c","mag":"1970724952","pmid":"https://pubmed.ncbi.nlm.nih.gov/7556594"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(95)00884-c","doi":"https://doi.org/10.1016/0014-5793(95)00884-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(95)00884-c","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2895%2900884-C","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2895%2900884-C","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023205657","display_name":"Alexei Morozov","orcid":"https://orcid.org/0000-0003-0495-3987","observed_orcids":["https://orcid.org/0000-0003-0495-3987"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Morozov","raw_affiliation_strings":["Department of Biochemistry (M/C 536), University of Illinois at Chicago 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry (M/C 536), University of Illinois at Chicago 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016166287","display_name":"John R. Subjeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Subjeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087379293","display_name":"Pradip Raychaudhuri","orcid":"https://orcid.org/0000-0003-2968-4701","observed_orcids":["https://orcid.org/0000-0003-2968-4701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Raychaudhuri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.8671,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70649183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"371","issue":"3","first_page":"214","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv16-e7","display_name":"HPV16 E7","score":0.8809999823570251},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.6629999876022339},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C108447607","wikidata":"https://www.wikidata.org/wiki/Q18040073","display_name":"HSPA14","level":5,"score":0.8688879013061523},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.8093901872634888},{"id":"https://openalex.org/C197199866","wikidata":"https://www.wikidata.org/wiki/Q18027348","display_name":"HSPA4","level":5,"score":0.7900724411010742},{"id":"https://openalex.org/C103474985","wikidata":"https://www.wikidata.org/wiki/Q24786671","display_name":"HSPA12A","level":5,"score":0.7586455941200256},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.6765483021736145},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5980818271636963},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.5668796896934509},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5652896165847778},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5090569853782654},{"id":"https://openalex.org/C116010114","wikidata":"https://www.wikidata.org/wiki/Q18027345","display_name":"HSPA2","level":4,"score":0.49478548765182495},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.49190735816955566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4680079519748688},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4651528298854828},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4369896650314331},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.41002756357192993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3640254735946655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15933671593666077},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.1264258623123169},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.08034726977348328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06907704472541809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050957","descriptor_name":"HSP110 Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(95)00884-c","doi":"https://doi.org/10.1016/0014-5793(95)00884-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(95)00884-c","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2895%2900884-C","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:7556594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7556594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(95)00884-c","doi":"https://doi.org/10.1016/0014-5793(95)00884-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(95)00884-c","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2895%2900884-C","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970724952.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W329260047","https://openalex.org/W1559244741","https://openalex.org/W1566324366","https://openalex.org/W1589329776","https://openalex.org/W1614185919","https://openalex.org/W1769448430","https://openalex.org/W1838616807","https://openalex.org/W1902390288","https://openalex.org/W1960870195","https://openalex.org/W1974391793","https://openalex.org/W1980431043","https://openalex.org/W1984380632","https://openalex.org/W2000092309","https://openalex.org/W2006684636","https://openalex.org/W2021253208","https://openalex.org/W2027590165","https://openalex.org/W2038812293","https://openalex.org/W2057058623","https://openalex.org/W2089473305","https://openalex.org/W2091230331","https://openalex.org/W2108066941","https://openalex.org/W2126613339","https://openalex.org/W2134812217","https://openalex.org/W2137417707","https://openalex.org/W2138461309","https://openalex.org/W2144634347","https://openalex.org/W2159361278","https://openalex.org/W2314225431","https://openalex.org/W4294216491","https://openalex.org/W4322085991"],"related_works":["https://openalex.org/W2413356054","https://openalex.org/W1759315945","https://openalex.org/W7097414630","https://openalex.org/W2000092309","https://openalex.org/W1781902555","https://openalex.org/W139861653","https://openalex.org/W2013551831","https://openalex.org/W2269410728","https://openalex.org/W7099035007","https://openalex.org/W2354697855"],"abstract_inverted_index":{"Heat":[0],"shock":[1,15,50,66,80],"protein":[2,67],"genes":[3],"are":[4],"induced":[5,24],"by":[6,25],"various":[7],"kinds":[8],"of":[9,40,63,71,77,89,101],"stress.":[10],"Besides":[11],"stress,":[12],"the":[13,30,69,75,85,90,99,102],"heat":[14,49,65,79],"family":[16],"gene":[17],"hsp70":[18],"has":[19],"been":[20],"shown":[21],"to":[22,98],"be":[23],"growth-stimulating":[26],"agents":[27],"such":[28],"as":[29,53],"DNA":[31],"virus":[32],"oncoproteins":[33],"and":[34],"serum.":[35],"Here,":[36],"we":[37],"report":[38],"cloning":[39],"a":[41,46,54],"novel":[42],"cDNA":[43],"that":[44],"encodes":[45],"100":[47],"kDa":[48],"protein-related":[51],"polypeptide":[52],"human":[55],"papillomavirus":[56],"oncoprotein":[57],"E7-inducible":[58],"gene.":[59],"E7":[60,91],"induces":[61],"expression":[62],"this":[64,78],"at":[68],"level":[70],"RNA":[72],"synthesis.":[73],"Moreover,":[74],"induction":[76],"protein-mRNA":[81],"was":[82],"dependent":[83],"on":[84],"conserved":[86],"region":[87],"2":[88],"protein,":[92],"which":[93],"is":[94],"essential":[95],"for":[96],"binding":[97],"proteins":[100],"retinoblastoma":[103],"family.":[104]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}