{"id":"https://openalex.org/W1970722015","doi":"https://doi.org/10.5551/jat.13.240","title":"Acute Inhibition of Lymphatic Cholesterol Transport in Rat Intestine by SCH 58053","display_name":"Acute Inhibition of Lymphatic Cholesterol Transport in Rat Intestine by SCH 58053","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1970722015","doi":"https://doi.org/10.5551/jat.13.240","mag":"1970722015","pmid":"https://pubmed.ncbi.nlm.nih.gov/17146152"},"language":"en","primary_location":{"id":"doi:10.5551/jat.13.240","doi":"https://doi.org/10.5551/jat.13.240","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat.13.240","pdf_url":"https://www.jstage.jst.go.jp/article/jat/13/5/13_5_240/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jstage.jst.go.jp/article/jat/13/5/13_5_240/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014133166","display_name":"Hiroshi Hayashi","orcid":"https://orcid.org/0000-0001-8202-9867","observed_orcids":["https://orcid.org/0000-0001-8202-9867"]},"institutions":[{"id":"https://openalex.org/I4210139667","display_name":"International University Of Health And Welfare Atami Hospital","ror":"https://ror.org/04gr92547","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210139667"]},{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]},{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Hayashi","raw_affiliation_strings":["Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology","Department of Internal Medicine, Atami Hospital, International University of Health and Welfare"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]},{"raw_affiliation_string":"Department of Internal Medicine, Atami Hospital, International University of Health and Welfare","institution_ids":["https://openalex.org/I4210139667","https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031499038","display_name":"Setsuko Kanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Setsuko Kanai","raw_affiliation_strings":["Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102398216","display_name":"Yoshihiko Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139667","display_name":"International University Of Health And Welfare Atami Hospital","ror":"https://ror.org/04gr92547","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210139667"]},{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Yamada","raw_affiliation_strings":["Department of Internal Medicine, Atami Hospital, International University of Health and Welfare"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Atami Hospital, International University of Health and Welfare","institution_ids":["https://openalex.org/I4210139667","https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021291521","display_name":"Motoo Tsushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139667","display_name":"International University Of Health And Welfare Atami Hospital","ror":"https://ror.org/04gr92547","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210139667"]},{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoo Tsushima","raw_affiliation_strings":["Department of Internal Medicine, Atami Hospital, International University of Health and Welfare"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Atami Hospital, International University of Health and Welfare","institution_ids":["https://openalex.org/I4210139667","https://openalex.org/I79072001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109142415","display_name":"Kyoko Miyasaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Miyasaka","raw_affiliation_strings":["Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology","institution_ids":["https://openalex.org/I4210140609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.339,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66264699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"5","first_page":"240","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-lymphatic-transport","display_name":"intestinal lymphatic transport","score":0.746999979019165},{"id":"https://openalex.org/keywords/cholesterol-absorption","display_name":"cholesterol absorption","score":0.6179999709129333},{"id":"https://openalex.org/keywords/triglyceride-transport","display_name":"triglyceride transport","score":0.8420000076293945},{"id":"https://openalex.org/keywords/free-cholesterol","display_name":"free cholesterol","score":0.5609999895095825},{"id":"https://openalex.org/keywords/lipid-emulsions","display_name":"lipid emulsions","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.7873923778533936},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.7306057214736938},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.7263509035110474},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6464868187904358},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6168030500411987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5859141945838928},{"id":"https://openalex.org/C2781157690","wikidata":"https://www.wikidata.org/wiki/Q413929","display_name":"Triolein","level":4,"score":0.5847269892692566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5234531760215759},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48157405853271484},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.46344542503356934},{"id":"https://openalex.org/C11772777","wikidata":"https://www.wikidata.org/wiki/Q423126","display_name":"Chylomicron","level":5,"score":0.4548552334308624},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4125983417034149},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33501318097114563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33341294527053833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1948322355747223},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15941447019577026},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.06539648771286011},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.0},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001384","descriptor_name":"Azetidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5551/jat.13.240","doi":"https://doi.org/10.5551/jat.13.240","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat.13.240","pdf_url":"https://www.jstage.jst.go.jp/article/jat/13/5/13_5_240/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},{"id":"pmid:17146152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17146152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of atherosclerosis and thrombosis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5551/jat.13.240","doi":"https://doi.org/10.5551/jat.13.240","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat.13.240","pdf_url":"https://www.jstage.jst.go.jp/article/jat/13/5/13_5_240/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970722015.pdf","grobid_xml":"https://content.openalex.org/works/W1970722015.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W17067511","https://openalex.org/W1586878603","https://openalex.org/W1879954941","https://openalex.org/W1983422922","https://openalex.org/W1987157458","https://openalex.org/W1987507883","https://openalex.org/W1993652095","https://openalex.org/W2015503831","https://openalex.org/W2021473986","https://openalex.org/W2029158612","https://openalex.org/W2035933628","https://openalex.org/W2060148367","https://openalex.org/W2060327165","https://openalex.org/W2104109023","https://openalex.org/W2111385165","https://openalex.org/W2113284407","https://openalex.org/W2115366657","https://openalex.org/W2123936150","https://openalex.org/W2139958752","https://openalex.org/W2163252871","https://openalex.org/W2168526937","https://openalex.org/W2168876694","https://openalex.org/W2169523655","https://openalex.org/W2175672872","https://openalex.org/W2186296848","https://openalex.org/W2186696919","https://openalex.org/W2227540966"],"related_works":["https://openalex.org/W2012392491","https://openalex.org/W2043189319","https://openalex.org/W2115366657","https://openalex.org/W1987157458","https://openalex.org/W3182267531","https://openalex.org/W2415830983","https://openalex.org/W2346576262","https://openalex.org/W2189179707","https://openalex.org/W7095349156","https://openalex.org/W1980739771"],"abstract_inverted_index":{"To":[0],"clarify":[1],"the":[2,27,69,82,125,128,135,139,157],"pharmacological":[3],"mechanism":[4],"of":[5,11,45,52,57,118,127,152],"ezetimibe,":[6,12],"SCH":[7,31,91,114,143],"58053,":[8,32],"an":[9],"analog":[10],"was":[13,29,37,131],"intraduodenally":[14],"administered":[15,38],"to":[16,75,107,121,134],"lymph-fistula":[17],"rats,":[18],"and":[19,54,149],"its":[20],"effect":[21],"on":[22],"lymphatic":[23,96,153],"lipid":[24,47,70,83],"transport":[25,155],"in":[26,103,124,156],"intestine":[28],"monitored.":[30],"5.0":[33,64],"mg/kg":[34,65],"body":[35,66],"weight,":[36],"one":[39],"hour":[40],"before":[41],"a":[42,46,146],"5-hour":[43],"infusion":[44],"emulsion":[48,71,84],"containing":[49],"40":[50],"micromol/h":[51,56],"triolein":[53],"2.74":[55],"cholesterol":[58,97,120,123,154],"(Experiment":[59,89],"1)":[60],"or":[61],"co-administered":[62],"at":[63],"weight/h":[67],"with":[68,81],"for":[72,86],"4":[73],"hours":[74,88],"rats":[76,109,130],"that":[77,110,142],"had":[78],"been":[79],"infused":[80],"alone":[85],"3":[87],"2).":[90],"58053":[92,144],"administration":[93],"significantly":[94],"inhibited":[95],"transport,":[98,102],"but":[99],"not":[100,112],"triglyceride":[101],"both":[104],"groups":[105],"compared":[106,133],"control":[108,136],"did":[111],"receive":[113],"58053.":[115],"The":[116],"ratio":[117],"free":[119],"total":[122],"lymph":[126],"treated":[129],"unchanged":[132],"rats.":[137],"Thus,":[138],"results":[140],"showed":[141],"is":[145],"potent,":[147],"rapid,":[148],"selective":[150],"inhibitor":[151],"intestine.":[158]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
