{"id":"https://openalex.org/W1970720809","doi":"https://doi.org/10.1164/ajrccm/140.5.1348","title":"Effect of a Leukotriene Antagonist, LY171883, on Cold Air-induced Bronchoconstriction in Asthmatics","display_name":"Effect of a Leukotriene Antagonist, LY171883, on Cold Air-induced Bronchoconstriction in Asthmatics","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W1970720809","doi":"https://doi.org/10.1164/ajrccm/140.5.1348","mag":"1970720809","pmid":"https://pubmed.ncbi.nlm.nih.gov/2817597"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/140.5.1348","doi":"https://doi.org/10.1164/ajrccm/140.5.1348","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/140.5.1348","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046059982","display_name":"Elliot Israel","orcid":"https://orcid.org/0000-0002-2470-856X","observed_orcids":["https://orcid.org/0000-0002-2470-856X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Elliot Israel","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Department of Medicine, Beth Israel Hospital, Boston,Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Department of Medicine, Beth Israel Hospital, Boston,Massachusetts","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031103832","display_name":"Elizabeth F. Juniper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Elizabeth F. Juniper","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039218212","display_name":"John Thomas Callaghan","orcid":"https://orcid.org/0000-0001-7851-5651","observed_orcids":["https://orcid.org/0000-0001-7851-5651"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"John T. Callaghan","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009259809","display_name":"Praveen N. Mathur","orcid":"https://orcid.org/0009-0003-9795-2744","observed_orcids":["https://orcid.org/0009-0003-9795-2744"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Praveen N. Mathur","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111509052","display_name":"Marilyn M. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Marilyn M. Morris","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025815336","display_name":"Anthony R. Dowell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Anthony R. Dowell","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109930425","display_name":"Greg G. Enas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Greg G. Enas","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113876179","display_name":"Frederick E. Hargreave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Frederick E. Hargreave","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021045413","display_name":"Jeffrey M. Drazen","orcid":"https://orcid.org/0000-0003-2715-9890","observed_orcids":["https://orcid.org/0000-0003-2715-9890"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Drazen","raw_affiliation_strings":["From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine, Beth Israel, Children's (Ina Sue Perlmutter Laboratory), and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; the Department of Clinical Epidemiology and Biostatistics, McMaster University, and the Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; the Departments of Medicine and Pharmacology, Indiana University School of Medicine, and the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I4394709130","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1957,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.94521868,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"140","issue":"5","first_page":"1348","last_page":"1353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukotriene-d4-receptor-antagonist","display_name":"leukotriene D4 receptor antagonist","score":0.9300000071525574},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7680000066757202},{"id":"https://openalex.org/keywords/isocapnic-hyperpnea","display_name":"isocapnic hyperpnea","score":0.9769999980926514},{"id":"https://openalex.org/keywords/respiratory-heat-loss","display_name":"respiratory heat loss","score":0.7770000100135803},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.6520000100135803},{"id":"https://openalex.org/keywords/bronchospasm","display_name":"bronchospasm","score":0.5709999799728394},{"id":"https://openalex.org/keywords/chest-tightness","display_name":"chest tightness","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.9492000341415405},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6696296334266663},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4992365837097168},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.4833073616027832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43009310960769653},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27135634422302246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18183472752571106},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05290213227272034}],"mesh":[{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001986","descriptor_name":"Bronchial Spasm","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm/140.5.1348","doi":"https://doi.org/10.1164/ajrccm/140.5.1348","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/140.5.1348","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:2817597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2817597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1019611912","display_name":null,"funder_award_id":"RR01302","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W122738027","https://openalex.org/W166776206","https://openalex.org/W1702194620","https://openalex.org/W1824477642","https://openalex.org/W1919903996","https://openalex.org/W1934334043","https://openalex.org/W1945429092","https://openalex.org/W1978177900","https://openalex.org/W2012607477","https://openalex.org/W2052828945","https://openalex.org/W2065631060","https://openalex.org/W2080181402","https://openalex.org/W2087142685","https://openalex.org/W2100279620","https://openalex.org/W2111133720","https://openalex.org/W2122275055","https://openalex.org/W2123349121","https://openalex.org/W2137401824","https://openalex.org/W2175588761","https://openalex.org/W2345804399"],"related_works":["https://openalex.org/W1824477642","https://openalex.org/W2002351007","https://openalex.org/W2139186475","https://openalex.org/W2132940813","https://openalex.org/W2043770111","https://openalex.org/W2049841970","https://openalex.org/W2057323207","https://openalex.org/W2345804399","https://openalex.org/W2058534254","https://openalex.org/W1990214413"],"abstract_inverted_index":{"Isocapnic":[0],"hyperpnea":[1],"(ISH)":[2],"of":[3,29,41,70,152,225,237,249],"cold":[4,53],"air":[5,54],"induces":[6],"bronchoconstriction":[7,23,242],"in":[8,56,85,88,159,162,187,199,240],"many":[9],"asthmatic":[10],"subjects.":[11],"Although":[12],"this":[13,22],"response":[14,51],"is":[15,19,24,206],"well":[16],"described,":[17],"it":[18],"unclear":[20],"whether":[21,34],"related":[25],"to":[26,52,119,131,234,245],"the":[27,49,112,121,160,202,209,226,229,235],"release":[28],"bronchoactive":[30],"mediators.":[31],"We":[32],"examined":[33],"pretreatment":[35],"with":[36,72,129,134,191,208],"LY171883,":[37],"a":[38,59,78,86,150,184],"competitive":[39],"antagonist":[40],"leukotriene":[42],"D4":[43],"activity":[44],"via":[45],"LTD4":[46,212,250],"receptors,":[47],"reduced":[48],"bronchospastic":[50],"ISH":[55,217],"asthmatics":[57],"using":[58],"randomized,":[60],"double-blind,":[61],"two-phase":[62],"crossover":[63],"design.":[64],"In":[65],"20":[66],"subjects,":[67,181],"2":[68],"wk":[69],"treatment":[71],"either":[73],"LY171883":[74,110,135,155,192,205],"600":[75],"mg":[76],"twice":[77],"day":[79],"or":[80],"placebo":[81,94,130],"did":[82],"not":[83],"result":[84],"change":[87],"FEV1":[89,122],"(3.45":[90],"+/-":[91,97],"0.21":[92],"L":[93,99],"versus":[95],"3.59":[96],"0.20":[98],"LY171883;":[100],"p":[101,169],"greater":[102,157],"than":[103,138,171,195],"0.05).":[104,139],"Nineteen":[105],"subjects":[106,165,203],"underwent":[107],"cold-air":[108,216],"ISH;":[109],"increased":[111],"geometric":[113],"mean":[114],"respiratory":[115],"heat":[116],"loss":[117],"required":[118],"reduce":[120],"by":[123,179],"20%":[124],"(PD20RHE)":[125],"from":[126],"1.00":[127],"kcal/min":[128,133],"1.24":[132],"(p":[136,193],"less":[137,170,194],"A":[140],"similar":[141],"difference":[142],"was":[143,183],"noted":[144],"when":[145],"responses":[146],"were":[147],"expressed":[148],"as":[149],"function":[151],"minute":[153],"ventilation.":[154],"produced":[156],"shifts":[158],"PD20RHE":[161,200,230],"more":[163],"reactive":[164],"(r":[166],"=":[167],"0.69,":[168],"0.002).":[172],"Among":[173],"11":[174],"different":[175],"symptom":[176],"scores":[177],"recorded":[178],"18":[180],"there":[182],"significant":[185],"decrease":[186],"daytime":[188],"chest":[189],"tightness":[190],"0.03).":[196],"The":[197,222],"increase":[198],"while":[201],"received":[204],"consistent":[207],"hypothesis":[210],"that":[211],"becomes":[213],"available":[214],"during":[215],"and":[218],"may":[219,231],"mediate":[220],"bronchoconstriction.":[221],"small":[223],"magnitude":[224],"effect":[227],"on":[228],"be":[232],"due":[233],"role":[236],"other":[238],"mediators":[239],"cold-air-induced":[241],"or,":[243],"alternatively,":[244],"an":[246],"inadequate":[247],"blockade":[248],"effects.":[251]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
