{"id":"https://openalex.org/W1970720379","doi":"https://doi.org/10.1002/eji.200535050","title":"The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells","display_name":"The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells","publication_year":2005,"publication_date":"2005-10-24","ids":{"openalex":"https://openalex.org/W1970720379","doi":"https://doi.org/10.1002/eji.200535050","mag":"1970720379","pmid":"https://pubmed.ncbi.nlm.nih.gov/16245362"},"language":"en","primary_location":{"id":"doi:10.1002/eji.200535050","doi":"https://doi.org/10.1002/eji.200535050","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.200535050","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030940837","display_name":"Markus Haug","orcid":"https://orcid.org/0000-0001-6023-7972","observed_orcids":["https://orcid.org/0000-0001-6023-7972"]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Haug","raw_affiliation_strings":["Children's Hospital, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019507729","display_name":"Luciana Dannecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luciana Dannecker","raw_affiliation_strings":["Children's Hospital, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025950726","display_name":"Carsten P. Schepp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten\u2004P. Schepp","raw_affiliation_strings":["Children's Hospital, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090475940","display_name":"William W. Kwok","orcid":"https://orcid.org/0000-0003-4843-4599","observed_orcids":["https://orcid.org/0000-0003-4843-4599"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William\u2004W. Kwok","raw_affiliation_strings":["Benaroya Research Institute, Virginia Mason Research Center, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute, Virginia Mason Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047036678","display_name":"Dorothee Wernet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorothee Wernet","raw_affiliation_strings":["Department of Transfusion Medicine, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transfusion Medicine, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019862484","display_name":"Jane Hoyt Buckner","orcid":"https://orcid.org/0000-0002-9005-1885","observed_orcids":["https://orcid.org/0000-0002-9005-1885"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane\u2004H. Buckner","raw_affiliation_strings":["Benaroya Research Institute, Virginia Mason Research Center, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute, Virginia Mason Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073736169","display_name":"Hubert Kalbacher","orcid":"https://orcid.org/0000-0002-7862-277X","observed_orcids":["https://orcid.org/0000-0002-7862-277X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubert Kalbacher","raw_affiliation_strings":["Medical and Natural Sciences Research Centre (MNF), University of Tuebingen, Tu\u0308bingen, Germany","Medical and Natural Sciences Research Centre (MNF), University of Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Natural Sciences Research Centre (MNF), University of Tuebingen, Tu\u0308bingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Medical and Natural Sciences Research Centre (MNF), University of Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019027979","display_name":"Guenther E. Dannecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guenther\u2004E. Dannecker","raw_affiliation_strings":["Department of Pediatrics and Pediatric Rheumatology, Olgahospital, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Pediatric Rheumatology, Olgahospital, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022326746","display_name":"Ursula Holzer","orcid":"https://orcid.org/0000-0002-2424-4654","observed_orcids":["https://orcid.org/0000-0002-2424-4654"]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ursula Holzer","raw_affiliation_strings":["Children's Hospital, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022326746"],"corresponding_institution_ids":["https://openalex.org/I4210125796","https://openalex.org/I8087733"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.5101,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.88618126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"35","issue":"11","first_page":"3163","last_page":"3172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9670000076293945},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.9890000224113464},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.847000002861023},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.734000027179718},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tetanus-toxin","display_name":"tetanus toxin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/influenza-hemagglutinin","display_name":"influenza hemagglutinin","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.640999972820282},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7547926902770996},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6807150840759277},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6149923205375671},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5388453006744385},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5375895500183105},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5366069674491882},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.506897509098053},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.5004222393035889},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.499204158782959},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.4851711392402649},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.4582573175430298},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42865121364593506},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.42598670721054077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4242088794708252},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4213683605194092},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.406879723072052},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31430351734161377},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21341463923454285},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20549821853637695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16939592361450195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.200535050","doi":"https://doi.org/10.1002/eji.200535050","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.200535050","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16245362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16245362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5899999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1511272968","https://openalex.org/W1515599953","https://openalex.org/W1532719760","https://openalex.org/W1540090690","https://openalex.org/W1585007382","https://openalex.org/W1963770237","https://openalex.org/W1965377917","https://openalex.org/W1965475982","https://openalex.org/W1965815841","https://openalex.org/W1972486638","https://openalex.org/W1973401187","https://openalex.org/W1990772742","https://openalex.org/W1994048581","https://openalex.org/W1997390346","https://openalex.org/W2001015172","https://openalex.org/W2002704444","https://openalex.org/W2005570998","https://openalex.org/W2005688001","https://openalex.org/W2021986528","https://openalex.org/W2028041423","https://openalex.org/W2028243344","https://openalex.org/W2037455416","https://openalex.org/W2038552490","https://openalex.org/W2044644799","https://openalex.org/W2050193276","https://openalex.org/W2070356198","https://openalex.org/W2083064282","https://openalex.org/W2090084038","https://openalex.org/W2097373411","https://openalex.org/W2101189282","https://openalex.org/W2102956395","https://openalex.org/W2116235676","https://openalex.org/W2116296842","https://openalex.org/W2139731109","https://openalex.org/W2144652377","https://openalex.org/W2155906523","https://openalex.org/W2162034771","https://openalex.org/W2163443542","https://openalex.org/W2164989415","https://openalex.org/W2169299767","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1520421559","https://openalex.org/W2090799771","https://openalex.org/W40786643","https://openalex.org/W4237317203","https://openalex.org/W1531842126","https://openalex.org/W2134347949","https://openalex.org/W2109580778","https://openalex.org/W2034919059","https://openalex.org/W152655721","https://openalex.org/W2143161597"],"abstract_inverted_index":{"Heat":[0],"shock":[1],"proteins":[2],"(HSP)":[3],"can":[4],"interact":[5],"with":[6,145],"a":[7],"wide":[8],"variety":[9],"of":[10,25,36,53,74,79,94,114,128,141,163,177,191],"peptides":[11,81,96,193],"and":[12,67,100,112,165,186],"the":[13,51,77,92,105,126,142,175,189],"resulting":[14],"HSP:peptide":[15,26],"complexes":[16,27,121],"are":[17],"known":[18],"to":[19,28,104,109,124,150,179,187],"be":[20],"highly":[21],"immunogenic.":[22],"The":[23],"ability":[24],"elicit":[29,151],"CD8+":[30],"T":[31,55,68,118,131,168,183,197],"cell":[32,69,169,184],"responses":[33],"by":[34,135],"cross-presentation":[35],"exogenous":[37],"antigen":[38,164],"via":[39,82],"MHC":[40,83],"class":[41,84],"I":[42],"is":[43,57],"well":[44],"known.":[45],"In":[46,86],"contrast,":[47],"their":[48],"role":[49],"in":[50,65,76,194],"activation":[52,111],"CD4+":[54,117,130,182,196],"cells":[56,132],"less":[58],"clearly":[59],"defined,":[60],"although":[61],"several":[62],"recent":[63],"studies":[64],"mice":[66],"lines":[70],"suggest":[71],"an":[72,152],"involvement":[73],"HSP":[75],"presentation":[78],"antigenic":[80,95,143],"II.":[85],"this":[87],"study":[88],"we":[89,173],"have":[90],"investigated":[91],"potential":[93,176],"from":[97],"tetanus":[98],"toxin":[99],"influenza":[101],"hemagglutinin":[102],"complexed":[103],"human":[106,115,195],"stress-inducible":[107],"Hsp70":[108,146,178],"enhance":[110,180],"proliferation":[113,127,185],"memory":[116],"cells.":[119,198],"Hsp70:peptide":[120],"were":[122],"found":[123],"amplify":[125],"antigen-specific":[129,153,181],"as":[133],"confirmed":[134],"HLA-DR":[136],"tetramer":[137],"staining.":[138],"Complex":[139],"formation":[140],"peptide":[144],"was":[147,157],"absolutely":[148],"required":[149],"amplification.":[154],"This":[155],"effect":[156],"most":[158],"pronounced":[159],"at":[160],"low":[161],"doses":[162],"decreasing":[166],"APC/CD4+":[167],"ratios.":[170],"Taken":[171],"together,":[172],"show":[174],"increase":[188],"immunogenicity":[190],"presented":[192]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
