{"id":"https://openalex.org/W1970656086","doi":"https://doi.org/10.1055/s-2007-1014457","title":"Misuse of Zopiclone and Convulsions during Withdrawal","display_name":"Misuse of Zopiclone and Convulsions during Withdrawal","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1970656086","doi":"https://doi.org/10.1055/s-2007-1014457","mag":"1970656086","pmid":"https://pubmed.ncbi.nlm.nih.gov/1754610"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-1014457","doi":"https://doi.org/10.1055/s-2007-1014457","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-1014457","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056042444","display_name":"Kari Aranko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. Aranko","raw_affiliation_strings":["Department of Clinical Pharmacology, University of Helsinki, Finland","Departments of Clinical Pharmacology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Departments of Clinical Pharmacology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055081645","display_name":"MARKUS M. HENRIKSSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Henriksson","raw_affiliation_strings":["Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047266894","display_name":"Christer Hublin","orcid":"https://orcid.org/0000-0003-0558-9881","observed_orcids":["https://orcid.org/0000-0003-0558-9881"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"C. Hublin","raw_affiliation_strings":["and Neurology University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland","Neurology University of Helsinki and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and Neurology University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Neurology University of Helsinki and","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110104783","display_name":"Anna Maria Sepp\u00e2l\u00e2inen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Sepp\u00e4l\u00e4inen","raw_affiliation_strings":["and Neurology University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland","Neurology University of Helsinki and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and Neurology University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Neurology University of Helsinki and","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9054,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.72324582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"04","first_page":"138","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zopiclone","display_name":"zopiclone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.8140000104904175},{"id":"https://openalex.org/keywords/benzodiazepine-withdrawal","display_name":"benzodiazepine withdrawal","score":0.7910000085830688},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.8119999766349792},{"id":"https://openalex.org/keywords/non-benzodiazepine-hypnotics","display_name":"non-benzodiazepine hypnotics","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.6990000009536743},{"id":"https://openalex.org/keywords/trimipramine","display_name":"trimipramine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/promazine","display_name":"promazine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2777810057","wikidata":"https://www.wikidata.org/wiki/Q220426","display_name":"Zopiclone","level":3,"score":0.9842926263809204},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.6780001521110535},{"id":"https://openalex.org/C2777010014","wikidata":"https://www.wikidata.org/wiki/Q852376","display_name":"Convulsion","level":3,"score":0.6490545868873596},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.503091037273407},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44401755928993225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3504860997200012},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21478548645973206},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.09489408135414124}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2007-1014457","doi":"https://doi.org/10.1055/s-2007-1014457","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-1014457","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},{"id":"pmid:1754610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1754610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410640735","https://openalex.org/W2093577047","https://openalex.org/W1606011471","https://openalex.org/W3194255584","https://openalex.org/W4244809507","https://openalex.org/W2144735198","https://openalex.org/W2379998685","https://openalex.org/W3197388417","https://openalex.org/W88017504","https://openalex.org/W94253797"],"abstract_inverted_index":{"It":[0,81],"has":[1],"been":[2],"documented":[3],"that":[4,84],"benzodiazepines":[5],"have":[6,74],"the":[7,18,32,52,77],"potential":[8],"to":[9,76,96],"cause":[10,87],"dependence":[11],"and":[12,71,92],"withdrawal":[13,62,93],"reactions,":[14],"including":[15],"convulsions.":[16,80],"However,":[17],"available":[19],"data":[20],"concerning":[21],"zopiclone,":[22,42],"a":[23,35],"nonbenzodiazepine":[24],"hypnotic,":[25],"are":[26],"insufficient.":[27],"The":[28,65],"present":[29],"study":[30],"describes":[31],"case":[33],"of":[34,46,63,68,79,98],"36-":[36],"year-old":[37],"man":[38],"who":[39],"repeatedly":[40],"misused":[41],"in":[43],"daily":[44],"doses":[45],"60":[47,142],"-":[48,143],"90":[49,144],"mg.":[50],"Furthermore,":[51],"patient":[53],"suffered":[54],"from":[55],"convulsion":[56],"on":[57],"two":[58],"occasions":[59],"following":[60],"abrupt":[61],"zopiclone.":[64],"concominant":[66],"use":[67],"alcohol,":[69],"trimipramine,":[70],"promazine":[72],"may":[73,86],"contributed":[75],"development":[78],"is":[82],"concluded":[83],"zopiclone":[85],"problems":[88],"associated":[89],"with":[90],"misuse":[91],"reactions":[94],"similar":[95],"those":[97],"bezodiazepines.":[99],"Zusammenfassung":[100],"Es":[101],"ist":[102],"bekannt,":[103],"da\u00df":[104,187],"der":[105,134,173],"Mi\u00dfbrauch":[106,191],"von":[107,130,180],"Benzodiazepinen":[108],"Abh\u00e4ngigkeit":[109],"und":[110,170,192],"Entzugssymptome,":[111],"einschlie\u00dflich":[112],"Konvulsionen,":[113],"verursachen":[114,198],"kann.":[115,199],"\u00dcber":[116],"Zopiclon,":[117],"ein":[118],"Non-Benzodiazepin-Hypnotikum,":[119],"gibt":[120],"es":[121],"allerdings":[122],"nur":[123],"unzureichend":[124],"Daten.":[125],"Wir":[126],"beschreiben":[127],"einen":[128,151],"Fall":[129],"einem":[131],"36j\u00e4hrigen":[132],"Mann,":[133],"wiederholt":[135],"Zopiclon":[136,159,188],"mi\u00dfbrauchte,":[137],"wobei":[138],"die":[139,166,196],"t\u00e4gliche":[140],"Dosis":[141,158],"mg":[145],"war.":[146],"Der":[147],"Patient":[148],"hatte":[149],"zweimal":[150],"Krampfanfall,":[152],"nachdem":[153],"er":[154],"pl\u00f6tzlich":[155],"eine":[156],"hohe":[157],"abgesetzt":[160],"hatte.":[161],"Ein":[162],"m\u00e4\u00dfiger":[163],"Alkoholgebrauch":[164],"sowie":[165],"Behandlung":[167],"mit":[168],"Trimipramin":[169],"Promazin":[171],"zu":[172],"gleichen":[174],"Zeit":[175],"haben":[176],"m\u00f6glicherweise":[177],"zur":[178],"Ausl\u00f6sung":[179],"Konvulsionen":[181],"beigetragen.":[182],"Zusammenfassend":[183],"l\u00e4\u00dft":[184],"sich":[185],"feststellen,":[186],"Probleme":[189],"wie":[190,195],"Entzugssymptome":[193],"\u00e4hnlich":[194],"Benzodiazepine":[197]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}