{"id":"https://openalex.org/W1970576342","doi":"https://doi.org/10.1089/aid.2012.0026","title":"Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains","display_name":"Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W1970576342","doi":"https://doi.org/10.1089/aid.2012.0026","mag":"1970576342","pmid":"https://pubmed.ncbi.nlm.nih.gov/22607556","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484736"},"language":"en","primary_location":{"id":"doi:10.1089/aid.2012.0026","doi":"https://doi.org/10.1089/aid.2012.0026","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2012.0026","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3484736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006695153","display_name":"Geoffrey F\u00e9rir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Geoffrey F\u00e9rir","raw_affiliation_strings":["University of Leuven","Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017914492","display_name":"Dana Huskens","orcid":"https://orcid.org/0000-0002-5999-5685","observed_orcids":["https://orcid.org/0000-0002-5999-5685"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dana Huskens","raw_affiliation_strings":["University of Leuven","Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035605431","display_name":"Kenneth E. Palmer","orcid":"https://orcid.org/0000-0002-2811-1111","observed_orcids":["https://orcid.org/0000-0002-2811-1111"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Palmer","raw_affiliation_strings":["University of Louisville","Department of Pharmacology and Toxicology and Owensboro Cancer Research Program, James Graham Brown Cancer Center, University of Louisville, School of Medicine, Louisville, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology and Owensboro Cancer Research Program, James Graham Brown Cancer Center, University of Louisville, School of Medicine, Louisville, Kentucky","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031028049","display_name":"Daniel M. Boudreaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Boudreaux","raw_affiliation_strings":["University of Michigan","Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113547593","display_name":"Michael D. Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Swanson","raw_affiliation_strings":["University of Michigan","Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075367506","display_name":"David M. Markovitz","orcid":"https://orcid.org/0000-0003-3547-0849","observed_orcids":["https://orcid.org/0000-0003-3547-0849"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Markovitz","raw_affiliation_strings":["University of Michigan","Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Medical Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038319371","display_name":"Jan M. Balzarini","orcid":"https://orcid.org/0000-0003-2240-3321","observed_orcids":["https://orcid.org/0000-0003-2240-3321","https://orcid.org/0000-0003-1144-1808"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Balzarini","raw_affiliation_strings":["University of Leuven","Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023796496","display_name":"Dominique Schols","orcid":"https://orcid.org/0000-0003-3256-5850","observed_orcids":["https://orcid.org/0000-0003-3256-5850"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Dominique Schols","raw_affiliation_strings":["University of Leuven","Rega Institute for Medical Research, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Rega Institute for Medical Research, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023796496"],"corresponding_institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":3.0013,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.91362331,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"11","first_page":"1513","last_page":"1523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/griffithsin","display_name":"griffithsin","score":0.996999979019165},{"id":"https://openalex.org/keywords/carbohydrate-binding-agents","display_name":"carbohydrate-binding agents","score":0.996999979019165},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":1.0},{"id":"https://openalex.org/keywords/synergistic-antiviral-effect","display_name":"antiviral synergy","score":0.7480000257492065},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hha","display_name":"Hha","score":0.4339999854564667},{"id":"https://openalex.org/keywords/gna","display_name":"GNA","score":0.953000009059906},{"id":"https://openalex.org/keywords/topical-microbicides","display_name":"topical microbicides","score":0.781000018119812},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.6060000061988831},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.6253024935722351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.510323703289032},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.487341970205307},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.298957496881485},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.2838159203529358}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037121","descriptor_name":"Plant Lectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1089/aid.2012.0026","doi":"https://doi.org/10.1089/aid.2012.0026","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2012.0026","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2800514","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3484736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3484736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3484736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Res Hum Retroviruses","raw_type":"Text"},{"id":"pmid:22607556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22607556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/98459","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/98459","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/352014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22607556","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AIDS Research and Human Retroviruses, vol. 28 (11), (1513-1523)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2800514","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3484736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1295105018","display_name":null,"funder_award_id":"AI 076169","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1302757663","display_name":null,"funder_award_id":"PF/10/018","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G1909027151","display_name":"Antiviral lectins as microbicides","funder_award_id":"R01AI076169","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2692913314","display_name":null,"funder_award_id":"10/018","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G430449545","display_name":null,"funder_award_id":"PF 10/018","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G5705617950","display_name":null,"funder_award_id":"GOA/10/014","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G7982837333","display_name":"Combined Highly Active Anti-retroviral Microbicides","funder_award_id":"242135","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1505517942","https://openalex.org/W1979050735","https://openalex.org/W1987461539","https://openalex.org/W1996641092","https://openalex.org/W1999749052","https://openalex.org/W2005963291","https://openalex.org/W2006867156","https://openalex.org/W2009112181","https://openalex.org/W2011420702","https://openalex.org/W2019293593","https://openalex.org/W2020266663","https://openalex.org/W2020465880","https://openalex.org/W2020515447","https://openalex.org/W2024213191","https://openalex.org/W2025396127","https://openalex.org/W2031911044","https://openalex.org/W2040037851","https://openalex.org/W2045135963","https://openalex.org/W2047124972","https://openalex.org/W2053469021","https://openalex.org/W2054998003","https://openalex.org/W2056360005","https://openalex.org/W2063825413","https://openalex.org/W2063995574","https://openalex.org/W2071146614","https://openalex.org/W2077436109","https://openalex.org/W2077945404","https://openalex.org/W2079028174","https://openalex.org/W2080732718","https://openalex.org/W2082281440","https://openalex.org/W2083013562","https://openalex.org/W2085081199","https://openalex.org/W2085612023","https://openalex.org/W2086325331","https://openalex.org/W2092279499","https://openalex.org/W2098337603","https://openalex.org/W2115059789","https://openalex.org/W2115555391","https://openalex.org/W2118820599","https://openalex.org/W2119327257","https://openalex.org/W2129287888","https://openalex.org/W2141444589","https://openalex.org/W2143768741","https://openalex.org/W2146634980","https://openalex.org/W2147201324","https://openalex.org/W2150620920","https://openalex.org/W2151678945","https://openalex.org/W2152433082","https://openalex.org/W2154097024","https://openalex.org/W2156764168","https://openalex.org/W2158715155","https://openalex.org/W2162703468"],"related_works":["https://openalex.org/W2155243646","https://openalex.org/W7097642452","https://openalex.org/W2095480767","https://openalex.org/W2524861517","https://openalex.org/W2105124128","https://openalex.org/W1987461539","https://openalex.org/W2210715578","https://openalex.org/W2085787758","https://openalex.org/W7099189651","https://openalex.org/W2082281440"],"abstract_inverted_index":{"Carbohydrate-binding":[0],"agents":[1,7],"(CBAs)":[2],"are":[3,227],"potential":[4],"HIV":[5,32,248],"microbicidal":[6],"with":[8,86,136,193],"a":[9,202],"high":[10],"genetic":[11],"barrier":[12],"to":[13,17,106,178,246],"resistance.":[14],"We":[15],"wanted":[16],"evaluate":[18],"whether":[19],"two":[20,211],"mannose-specific":[21],"CBAs,":[22],"recognizing":[23],"multiple":[24],"and":[25,41,55,69,75,93,113,130,138,145,151,158,167,187],"often":[26],"distinct":[27,180],"glycan":[28,196,218],"structures":[29],"on":[30,81,183,199],"the":[31,82,184,222,230],"envelope":[33,186],"gp120,":[34],"can":[35],"interact":[36],"synergistically":[37],"against":[38,49,65,127,142,164,169],"HIV-1,":[39,165],"HIV-2,":[40,166],"HIV-1":[42,68,77,129,147,172],"strains":[43,78,148],"that":[44],"were":[45],"selected":[46],"for":[47,217,221,229],"resistance":[48],"particular":[50],"CBAs":[51,160,175,213],"[i.e.,":[52],"2G12":[53,73,143],"mAb":[54],"microvirin":[56],"(MVN)].":[57],"Paired":[58],"CBA/CBA":[59],"combinations":[60,123,155,235],"mainly":[61],"showed":[62,124,161],"synergistic":[63,162],"activity":[64,126,163],"both":[66],"wild-type":[67,128],"HIV-2":[70,131],"but":[71,133],"also":[72],"mAb-":[74,144],"MVN-resistant":[76,146],"as":[79],"based":[80],"median":[83],"effect":[84],"principle":[85],"combination":[87],"indices":[88],"(CIs)":[89],"ranging":[90],"between":[91,210],"0.29":[92],"0.97.":[94],"Upon":[95],"combination,":[96],"an":[97],"increase":[98],"in":[99,214,236],"antiviral":[100],"potency":[101],"of":[102,156,232],"griffithsin":[103],"(GRFT)":[104],"up":[105],"\u223c12-fold":[107],"(against":[108,111,115],"HIV-1),":[109],"\u223c8-fold":[110],"HIV-2),":[112],"\u223c6-fold":[114],"CBA-resistant":[116,171],"HIV-1)":[117],"was":[118,140],"observed.":[119],"In":[120],"contrast,":[121],"HHA/GNA":[122,223],"additive":[125],"strains,":[132],"remarkable":[134],"synergy":[135],"HHA":[137],"GNA":[139],"observed":[141],"(CI,":[149],"0.64":[150],"0.49,":[152],"respectively).":[153],"Overall,":[154],"GRFT":[157],"other":[159],"even":[168],"certain":[170],"strains.":[173],"The":[174],"tested":[176],"appear":[177],"have":[179],"binding":[181,197,219],"patterns":[182],"gp120":[185],"therefore":[188],"do":[189],"not":[190],"necessarily":[191],"compete":[192],"each":[194],"other's":[195],"sites":[198],"gp120.":[200],"As":[201],"result,":[203],"there":[204],"might":[205],"be":[206],"no":[207],"steric":[208],"hindrance":[209],"different":[212],"their":[215],"competition":[216],"(except":[220],"combination).":[224],"These":[225],"data":[226],"encouraging":[228],"use":[231],"paired":[233],"CBA":[234],"topical":[237],"microbicide":[238],"applications":[239],"(e.g.,":[240],"creams,":[241],"gels,":[242],"or":[243],"intravaginal":[244],"rings)":[245],"prevent":[247],"transmission.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}