{"id":"https://openalex.org/W1970568241","doi":"https://doi.org/10.3389/fimmu.2012.00335","title":"Human NK cell lytic granules and regulation of their exocytosis","display_name":"Human NK cell lytic granules and regulation of their exocytosis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1970568241","doi":"https://doi.org/10.3389/fimmu.2012.00335","mag":"1970568241","pmid":"https://pubmed.ncbi.nlm.nih.gov/23162553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3494098"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2012.00335","doi":"https://doi.org/10.3389/fimmu.2012.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2012.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00335/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038195681","display_name":"Konrad Krzewski","orcid":"https://orcid.org/0000-0002-9473-953X","observed_orcids":["https://orcid.org/0000-0002-9473-953X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Konrad Krzewski","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health Rockville, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105466343","display_name":"John E. Coligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Coligan","raw_affiliation_strings":["National Institutes of Health, Rockville, 20852, MARYLAND, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Rockville, 20852, MARYLAND, United States","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038195681"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":4.8623,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.95909867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"3","issue":null,"first_page":"335","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lytic-granules","display_name":"lytic granules","score":0.9929999709129333},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/granzymes","display_name":"granzymes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9120000004768372},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.847000002861023},{"id":"https://openalex.org/keywords/familial-hemophagocytic-lymphohistiocytosis","display_name":"familial hemophagocytic lymphohistiocytosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/griscelli-syndrome","display_name":"Griscelli syndrome","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.8619047403335571},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8303184509277344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6542007923126221},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.42788949608802795},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3807794451713562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36628860235214233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34252965450286865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32875460386276245},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.28682780265808105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07437199354171753},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06741374731063843},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2012.00335","doi":"https://doi.org/10.3389/fimmu.2012.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2012.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3494098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3494098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:23162553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23162553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:705684a326a54e7bab5851a0bec0ccc1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/705684a326a54e7bab5851a0bec0ccc1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 3 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2012.00335","doi":"https://doi.org/10.3389/fimmu.2012.00335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2012.00335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970568241.pdf","grobid_xml":"https://content.openalex.org/works/W1970568241.grobid-xml"},"referenced_works_count":234,"referenced_works":["https://openalex.org/W1492762298","https://openalex.org/W1502760858","https://openalex.org/W1508892593","https://openalex.org/W1508999928","https://openalex.org/W1509855903","https://openalex.org/W1517394132","https://openalex.org/W1536893104","https://openalex.org/W1537599002","https://openalex.org/W1539934168","https://openalex.org/W1540507088","https://openalex.org/W1544920052","https://openalex.org/W1550463937","https://openalex.org/W1556541026","https://openalex.org/W1560450744","https://openalex.org/W1561587838","https://openalex.org/W1571520647","https://openalex.org/W1574178834","https://openalex.org/W1582617014","https://openalex.org/W1587508560","https://openalex.org/W1616082630","https://openalex.org/W1634711419","https://openalex.org/W1662505552","https://openalex.org/W1669828090","https://openalex.org/W1762255128","https://openalex.org/W1825621539","https://openalex.org/W1892560324","https://openalex.org/W1943160106","https://openalex.org/W1953387685","https://openalex.org/W1965393381","https://openalex.org/W1966496217","https://openalex.org/W1968815565","https://openalex.org/W1969824361","https://openalex.org/W1970973262","https://openalex.org/W1971672785","https://openalex.org/W1973323097","https://openalex.org/W1973562333","https://openalex.org/W1974048218","https://openalex.org/W1979361047","https://openalex.org/W1979607272","https://openalex.org/W1981129782","https://openalex.org/W1981531114","https://openalex.org/W1982249894","https://openalex.org/W1982306166","https://openalex.org/W1983842560","https://openalex.org/W1985183555","https://openalex.org/W1985766571","https://openalex.org/W1986130505","https://openalex.org/W1986344524","https://openalex.org/W1986411025","https://openalex.org/W1987191562","https://openalex.org/W1988030748","https://openalex.org/W1988224733","https://openalex.org/W1990863238","https://openalex.org/W1991994777","https://openalex.org/W1993554383","https://openalex.org/W1994436896","https://openalex.org/W1995826417","https://openalex.org/W1996710888","https://openalex.org/W2000302106","https://openalex.org/W2002133764","https://openalex.org/W2004776380","https://openalex.org/W2006981341","https://openalex.org/W2008771266","https://openalex.org/W2009619778","https://openalex.org/W2013473454","https://openalex.org/W2014461574","https://openalex.org/W2014656971","https://openalex.org/W2017094373","https://openalex.org/W2018473508","https://openalex.org/W2021707377","https://openalex.org/W2022069273","https://openalex.org/W2022903394","https://openalex.org/W2024260190","https://openalex.org/W2026422112","https://openalex.org/W2027478410","https://openalex.org/W2027781207","https://openalex.org/W2027888498","https://openalex.org/W2028957664","https://openalex.org/W2029349480","https://openalex.org/W2030968105","https://openalex.org/W2031648930","https://openalex.org/W2033107431","https://openalex.org/W2033296826","https://openalex.org/W2034071655","https://openalex.org/W2034412119","https://openalex.org/W2034770000","https://openalex.org/W2035606942","https://openalex.org/W2036416567","https://openalex.org/W2037871133","https://openalex.org/W2037901546","https://openalex.org/W2038209572","https://openalex.org/W2038379511","https://openalex.org/W2038619375","https://openalex.org/W2040576001","https://openalex.org/W2041001296","https://openalex.org/W2041827175","https://openalex.org/W2042498353","https://openalex.org/W2043305034","https://openalex.org/W2044513489","https://openalex.org/W2046516719","https://openalex.org/W2046813237","https://openalex.org/W2047164801","https://openalex.org/W2048455227","https://openalex.org/W2048607411","https://openalex.org/W2050207545","https://openalex.org/W2051157884","https://openalex.org/W2051233096","https://openalex.org/W2052632028","https://openalex.org/W2053784823","https://openalex.org/W2054218102","https://openalex.org/W2054275629","https://openalex.org/W2056257393","https://openalex.org/W2056771287","https://openalex.org/W2057808630","https://openalex.org/W2057936936","https://openalex.org/W2058658949","https://openalex.org/W2059354338","https://openalex.org/W2061023783","https://openalex.org/W2062116205","https://openalex.org/W2062415238","https://openalex.org/W2063226596","https://openalex.org/W2064501243","https://openalex.org/W2068480490","https://openalex.org/W2069274491","https://openalex.org/W2070156993","https://openalex.org/W2070551124","https://openalex.org/W2070807737","https://openalex.org/W2072608587","https://openalex.org/W2073300038","https://openalex.org/W2075257799","https://openalex.org/W2079018122","https://openalex.org/W2080451146","https://openalex.org/W2080539640","https://openalex.org/W2084127936","https://openalex.org/W2084896925","https://openalex.org/W2085382985","https://openalex.org/W2085791288","https://openalex.org/W2088689826","https://openalex.org/W2089697869","https://openalex.org/W2089907993","https://openalex.org/W2090300117","https://openalex.org/W2093658044","https://openalex.org/W2094197540","https://openalex.org/W2095282336","https://openalex.org/W2095326716","https://openalex.org/W2096352497","https://openalex.org/W2098609440","https://openalex.org/W2098910355","https://openalex.org/W2099153373","https://openalex.org/W2099229662","https://openalex.org/W2099557607","https://openalex.org/W2101118828","https://openalex.org/W2101951149","https://openalex.org/W2102068100","https://openalex.org/W2102954334","https://openalex.org/W2103123151","https://openalex.org/W2103699489","https://openalex.org/W2105385389","https://openalex.org/W2106196463","https://openalex.org/W2107702121","https://openalex.org/W2107880476","https://openalex.org/W2109655591","https://openalex.org/W2109716633","https://openalex.org/W2110435881","https://openalex.org/W2110734772","https://openalex.org/W2111272289","https://openalex.org/W2111282994","https://openalex.org/W2112633838","https://openalex.org/W2114060183","https://openalex.org/W2116247281","https://openalex.org/W2118037346","https://openalex.org/W2118143380","https://openalex.org/W2119292197","https://openalex.org/W2122970793","https://openalex.org/W2124278766","https://openalex.org/W2124325580","https://openalex.org/W2125404510","https://openalex.org/W2128405340","https://openalex.org/W2128558707","https://openalex.org/W2130251604","https://openalex.org/W2132971223","https://openalex.org/W2133192284","https://openalex.org/W2134582553","https://openalex.org/W2136845302","https://openalex.org/W2138453647","https://openalex.org/W2140288892","https://openalex.org/W2140813750","https://openalex.org/W2141080152","https://openalex.org/W2141298031","https://openalex.org/W2141416399","https://openalex.org/W2147102470","https://openalex.org/W2148488002","https://openalex.org/W2149588455","https://openalex.org/W2149832954","https://openalex.org/W2150054315","https://openalex.org/W2152936734","https://openalex.org/W2153385228","https://openalex.org/W2154002416","https://openalex.org/W2154465669","https://openalex.org/W2155132039","https://openalex.org/W2159699644","https://openalex.org/W2160547985","https://openalex.org/W2161408389","https://openalex.org/W2162620875","https://openalex.org/W2163105800","https://openalex.org/W2163801648","https://openalex.org/W2164464853","https://openalex.org/W2165906760","https://openalex.org/W2165920713","https://openalex.org/W2166802464","https://openalex.org/W2168346227","https://openalex.org/W2169865172","https://openalex.org/W2170346276","https://openalex.org/W2170454176","https://openalex.org/W2171709048","https://openalex.org/W2286996290","https://openalex.org/W2317837650","https://openalex.org/W2336153715","https://openalex.org/W2409458263","https://openalex.org/W4211040987","https://openalex.org/W4211044652","https://openalex.org/W4233364073","https://openalex.org/W4233740983","https://openalex.org/W4238998177","https://openalex.org/W4252449600","https://openalex.org/W4253146410","https://openalex.org/W4313344709","https://openalex.org/W4313347692","https://openalex.org/W6649210851","https://openalex.org/W6682766770","https://openalex.org/W6755811877","https://openalex.org/W6864014924","https://openalex.org/W7073841126","https://openalex.org/W7073984807"],"related_works":["https://openalex.org/W4224997953","https://openalex.org/W2160232548","https://openalex.org/W2794989655","https://openalex.org/W2004373794","https://openalex.org/W1966642068","https://openalex.org/W2018311806","https://openalex.org/W3006778914","https://openalex.org/W1970043196","https://openalex.org/W2090300117","https://openalex.org/W7067515999"],"abstract_inverted_index":{"Natural":[0],"killer":[1],"(NK)":[2],"cells":[3,27,49,103,172],"form":[4],"a":[5,11,29,51,75],"subset":[6],"of":[7,31,47,61,81,85,101,143,148,160,169],"lymphocytes":[8],"that":[9,55],"play":[10],"key":[12],"role":[13,147],"in":[14,57,83,114,152,176],"immuno-surveillance":[15],"and":[16,21,37,66,95,124,156,173],"host":[17],"defense":[18],"against":[19],"cancer":[20],"viral":[22],"infections.":[23],"They":[24],"recognize":[25],"stressed":[26],"through":[28],"variety":[30],"germline-encoded":[32],"activating":[33],"cell":[34,93,109],"surface":[35],"receptors":[36],"utilize":[38],"their":[39,181],"cytotoxic":[40],"ability":[41],"to":[42,74,90,122],"eliminate":[43],"abnormal":[44],"cells.":[45,162],"Killing":[46],"target":[48,76,86,92],"is":[50],"complex,":[52],"multi-stage":[53],"process":[54],"concludes":[56],"the":[58,69,146,174,178],"directed":[59],"secretion":[60,117],"lytic":[62,99,115,153,167],"granules,":[63],"containing":[64],"perforin":[65,78],"granzymes,":[67],"at":[68],"immunological":[70],"synapse.":[71],"Upon":[72],"delivery":[73],"cell,":[77],"mediates":[79],"generation":[80],"pores":[82],"membranes":[84],"cells,":[87],"allowing":[88],"granzymes":[89],"access":[91],"cytoplasm":[94],"induce":[96],"apoptosis.":[97],"Therefore,":[98],"granules":[100,168],"NK":[102,108,157,171],"are":[104,120],"indispensable":[105],"for":[106],"normal":[107],"cytolytic":[110],"function.":[111],"Indeed,":[112],"defects":[113],"granule":[116,154],"lead":[118],"or":[119,136],"related":[121],"serious":[123],"often":[125],"fatal":[126],"diseases,":[127],"such":[128],"as":[129],"familial":[130],"hemophagocytic":[131],"lymphohistiocytosis":[132],"(FHL)":[133],"type":[134,139],"2-5":[135],"Griscelli":[137],"syndrome":[138],"2.":[140],"A":[141],"number":[142],"reports":[144],"highlight":[145],"several":[149],"proteins":[150],"involved":[151],"release":[155],"cell-mediated":[158],"killing":[159],"tumor":[161],"This":[163],"review":[164],"focuses":[165],"on":[166],"human":[170],"advancements":[175],"understanding":[177],"mechanisms":[179],"controlling":[180],"exocytosis.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
