{"id":"https://openalex.org/W1970533033","doi":"https://doi.org/10.1016/j.neulet.2005.03.011","title":"Effect of repeated nicotine exposure on high-affinity nicotinic acetylcholine receptor density in spontaneously hypertensive rats","display_name":"Effect of repeated nicotine exposure on high-affinity nicotinic acetylcholine receptor density in spontaneously hypertensive rats","publication_year":2005,"publication_date":"2005-04-02","ids":{"openalex":"https://openalex.org/W1970533033","doi":"https://doi.org/10.1016/j.neulet.2005.03.011","mag":"1970533033","pmid":"https://pubmed.ncbi.nlm.nih.gov/15911141"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2005.03.011","doi":"https://doi.org/10.1016/j.neulet.2005.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2005.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049175619","display_name":"Elizabeth J. Hohnadel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Hohnadel","raw_affiliation_strings":["Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","institution_ids":["https://openalex.org/I165733156","https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104753415","display_name":"Caterina M. Hernandez","orcid":"https://orcid.org/0000-0001-8951-0485","observed_orcids":["https://orcid.org/0000-0001-8951-0485"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caterina M. Hernandez","raw_affiliation_strings":["Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","Pharmacology and Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","institution_ids":["https://openalex.org/I165733156","https://openalex.org/I25041050"]},{"raw_affiliation_string":"Pharmacology and Toxicology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055712912","display_name":"Debra A. Gearhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra A. Gearhart","raw_affiliation_strings":["Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","institution_ids":["https://openalex.org/I165733156","https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028964250","display_name":"Alvin V. Terry","orcid":"https://orcid.org/0000-0003-2071-4767","observed_orcids":["https://orcid.org/0000-0003-2071-4767"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alvin V. Terry","raw_affiliation_strings":["Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","Pharmacology and Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus), Medical College of Georgia, Augusta, GA 30912, USA","institution_ids":["https://openalex.org/I165733156","https://openalex.org/I25041050"]},{"raw_affiliation_string":"Pharmacology and Toxicology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028964250"],"corresponding_institution_ids":["https://openalex.org/I165733156","https://openalex.org/I25041050"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.2332,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.47030915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"382","issue":"1-2","first_page":"158","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7850000262260437},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anterior-thalamic-nucleus","display_name":"anterior thalamic nuclei","score":0.9169999957084656},{"id":"https://openalex.org/keywords/brain-receptor-binding","display_name":"brain receptor binding","score":0.5},{"id":"https://openalex.org/keywords/alzheimer-s-disease-model","display_name":"Alzheimer's disease model","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8746300935745239},{"id":"https://openalex.org/C2780928369","wikidata":"https://www.wikidata.org/wiki/Q423783","display_name":"Epibatidine","level":5,"score":0.7966949939727783},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.7952781915664673},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.7015255689620972},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.6029852032661438},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5928648114204407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5721072554588318},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5253868699073792},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.5117864012718201},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4098743796348572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3901887536048889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787963390350342},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37113553285598755},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3543693721294403},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neulet.2005.03.011","doi":"https://doi.org/10.1016/j.neulet.2005.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2005.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:15911141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15911141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308528","display_name":"American Foundation for Pharmaceutical Education","ror":"https://ror.org/006dn3r34"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W72468019","https://openalex.org/W130685078","https://openalex.org/W249845531","https://openalex.org/W658467397","https://openalex.org/W1585413892","https://openalex.org/W1797048281","https://openalex.org/W1946541735","https://openalex.org/W1966565364","https://openalex.org/W1972140032","https://openalex.org/W1978427046","https://openalex.org/W1979212481","https://openalex.org/W1984552414","https://openalex.org/W1987883688","https://openalex.org/W1994437479","https://openalex.org/W1994806628","https://openalex.org/W1995084008","https://openalex.org/W1996605747","https://openalex.org/W2000647786","https://openalex.org/W2000786103","https://openalex.org/W2016228826","https://openalex.org/W2019707727","https://openalex.org/W2020370964","https://openalex.org/W2021664758","https://openalex.org/W2022074424","https://openalex.org/W2026188485","https://openalex.org/W2029196617","https://openalex.org/W2033484484","https://openalex.org/W2037441262","https://openalex.org/W2044831514","https://openalex.org/W2046324408","https://openalex.org/W2047444560","https://openalex.org/W2053602869","https://openalex.org/W2054389556","https://openalex.org/W2057585724","https://openalex.org/W2060902716","https://openalex.org/W2075467475","https://openalex.org/W2076583086","https://openalex.org/W2081000346","https://openalex.org/W2082064816","https://openalex.org/W2084758742","https://openalex.org/W2085605392","https://openalex.org/W2087823724","https://openalex.org/W2089075278","https://openalex.org/W2090019512","https://openalex.org/W2090198839","https://openalex.org/W2091374932","https://openalex.org/W2094321474","https://openalex.org/W2095847999","https://openalex.org/W2098894063","https://openalex.org/W2131568512","https://openalex.org/W2133948124","https://openalex.org/W2146949902","https://openalex.org/W2157513363","https://openalex.org/W2163815564","https://openalex.org/W2403092971","https://openalex.org/W2411795526","https://openalex.org/W4249741519","https://openalex.org/W4388311359","https://openalex.org/W6640696055","https://openalex.org/W6680709891"],"related_works":["https://openalex.org/W1987883688","https://openalex.org/W1596907982","https://openalex.org/W1966565364","https://openalex.org/W2085605392","https://openalex.org/W2460038048","https://openalex.org/W2037846477","https://openalex.org/W1978925616","https://openalex.org/W1979777300","https://openalex.org/W1972140032","https://openalex.org/W4249741519"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}