{"id":"https://openalex.org/W1970528355","doi":"https://doi.org/10.1038/oby.2006.279","title":"Metabolic Syndrome: Adenosine Monophosphate\u2010activated Protein Kinase and Malonyl Coenzyme A","display_name":"Metabolic Syndrome: Adenosine Monophosphate\u2010activated Protein Kinase and Malonyl Coenzyme A","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W1970528355","doi":"https://doi.org/10.1038/oby.2006.279","mag":"1970528355","pmid":"https://pubmed.ncbi.nlm.nih.gov/16642960"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2006.279","doi":"https://doi.org/10.1038/oby.2006.279","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2006.279","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2006.279","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2006.279","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055882378","display_name":"Neil B. Ruderman","orcid":"https://orcid.org/0000-0002-6589-6587","observed_orcids":["https://orcid.org/0000-0002-6589-6587"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil B. Ruderman","raw_affiliation_strings":["Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA. nrude@bumc.bu.edu","Boston University Medical Center, Division of Endocrinology, Diabetes Research Unit, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Boston University Medical Center, Boston, MA 02118, USA. nrude@bumc.bu.edu","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Boston University Medical Center, Division of Endocrinology, Diabetes Research Unit, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068371835","display_name":"Asish K. Saha","orcid":"https://orcid.org/0000-0003-1001-5110","observed_orcids":["https://orcid.org/0000-0003-1001-5110"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asish K. Saha","raw_affiliation_strings":["Boston University Medical Center, Division of Endocrinology, Diabetes Research Unit, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center, Division of Endocrinology, Diabetes Research Unit, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055882378"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":{"value":4980,"currency":"USD","value_usd":4980},"fwci":0.4284,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.34030376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"14","issue":"S2","first_page":"25S","last_page":"33S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8849999904632568},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fatty-acid-partitioning","display_name":"fatty acid partitioning","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ampk-activators","display_name":"AMPK activators","score":0.824999988079071},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2779876172","wikidata":"https://www.wikidata.org/wiki/Q318369","display_name":"Adenosine monophosphate","level":3,"score":0.668285608291626},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5614331960678101},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5288456678390503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4454803168773651},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.4119876027107239},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37676599621772766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3517754375934601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3350142240524292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3348950743675232},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3205242455005646},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23650798201560974},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.052239179611206055}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008316","descriptor_name":"Malonyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/oby.2006.279","doi":"https://doi.org/10.1038/oby.2006.279","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2006.279","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2006.279","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},{"id":"pmid:16642960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16642960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity (Silver Spring, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/oby.2006.279","doi":"https://doi.org/10.1038/oby.2006.279","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2006.279","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2006.279","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1746161432","display_name":null,"funder_award_id":"DK 19417","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1936097356","display_name":null,"funder_award_id":"DK-19514","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2879209435","display_name":"The AMPK/SIRT1  Partnershipand Its Biological Relevance","funder_award_id":"5r01dk019514-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7396650604","display_name":null,"funder_award_id":"P01-HL 08758-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970528355.pdf","grobid_xml":"https://content.openalex.org/works/W1970528355.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W170853393","https://openalex.org/W1748234316","https://openalex.org/W1749780042","https://openalex.org/W1794036496","https://openalex.org/W1970009760","https://openalex.org/W1973842058","https://openalex.org/W1978180139","https://openalex.org/W1982085282","https://openalex.org/W1983336199","https://openalex.org/W1986349550","https://openalex.org/W1991795789","https://openalex.org/W1992304595","https://openalex.org/W1994554353","https://openalex.org/W1995392322","https://openalex.org/W1996417808","https://openalex.org/W1998543682","https://openalex.org/W2006332285","https://openalex.org/W2008626933","https://openalex.org/W2011437165","https://openalex.org/W2012898950","https://openalex.org/W2022474551","https://openalex.org/W2027670788","https://openalex.org/W2030089671","https://openalex.org/W2031637294","https://openalex.org/W2039531356","https://openalex.org/W2040901874","https://openalex.org/W2043081431","https://openalex.org/W2043106623","https://openalex.org/W2046378557","https://openalex.org/W2049481764","https://openalex.org/W2053663631","https://openalex.org/W2055061083","https://openalex.org/W2067184340","https://openalex.org/W2069497802","https://openalex.org/W2074303577","https://openalex.org/W2080285792","https://openalex.org/W2083990676","https://openalex.org/W2087393295","https://openalex.org/W2094632969","https://openalex.org/W2096773810","https://openalex.org/W2096979086","https://openalex.org/W2104599590","https://openalex.org/W2108462699","https://openalex.org/W2114339108","https://openalex.org/W2114853986","https://openalex.org/W2116215087","https://openalex.org/W2117212522","https://openalex.org/W2121309304","https://openalex.org/W2121338998","https://openalex.org/W2121492052","https://openalex.org/W2123106337","https://openalex.org/W2123946088","https://openalex.org/W2124536446","https://openalex.org/W2126317966","https://openalex.org/W2126654945","https://openalex.org/W2127295385","https://openalex.org/W2134705701","https://openalex.org/W2135943330","https://openalex.org/W2150377102","https://openalex.org/W2150715002","https://openalex.org/W2151152924","https://openalex.org/W2153661281","https://openalex.org/W2154768987","https://openalex.org/W2170311057","https://openalex.org/W2170886970","https://openalex.org/W2171651779","https://openalex.org/W2316634532","https://openalex.org/W2411968291","https://openalex.org/W2416130519","https://openalex.org/W2430143578","https://openalex.org/W4235264311"],"related_works":["https://openalex.org/W1983336199","https://openalex.org/W7024198359","https://openalex.org/W2064370899","https://openalex.org/W2055061083","https://openalex.org/W2059431819","https://openalex.org/W2073625326","https://openalex.org/W2092722251","https://openalex.org/W2368167355","https://openalex.org/W2899323834","https://openalex.org/W7160223002"],"abstract_inverted_index":{"The":[0,114],"metabolic":[1,10,39],"syndrome":[2,40],"can":[3],"be":[4,68,88,133],"defined":[5],"as":[6],"a":[7,19,69],"state":[8],"of":[9,34,63,71,106],"dysregulation":[11,70,86],"characterized":[12],"by":[13,90,97],"insulin":[14],"resistance,":[15],"central":[16],"obesity,":[17],"and":[18,28,82,103,122],"predisposition":[20],"to":[21,41,49],"type":[22],"2":[23],"diabetes,":[24],"dyslipidemia,":[25],"premature":[26],"atherosclerosis,":[27],"other":[29,123],"diseases.":[30],"An":[31],"increasing":[32],"body":[33],"evidence":[35],"has":[36],"linked":[37],"the":[38,55,61,72],"abnormalities":[42,66],"in":[43,58,93,100],"lipid":[44,65],"metabolism":[45],"that":[46,119,125],"ultimately":[47],"lead":[48],"cellular":[50],"dysfunction.":[51],"We":[52],"review":[53],"here":[54],"hypothesis":[56],"that,":[57],"many":[59],"instances,":[60],"cause":[62],"these":[64],"could":[67,87,132],"adenosine":[73],"monophosphate-activated":[74],"protein":[75],"kinase":[76],"(AMPK)/malonyl":[77],"coenzyme":[78],"A":[79],"(CoA)":[80],"fuel-sensing":[81],"signaling":[83],"mechanism.":[84],"Such":[85],"reflected":[89],"isolated":[91],"increases":[92],"malonyl":[94,101,130],"CoA":[95,102,131],"or":[96],"concurrent":[98],"changes":[99],"AMPK,":[104],"both":[105],"which":[107],"would":[108],"alter":[109],"intracellular":[110],"fatty":[111],"acid":[112],"partitioning.":[113],"possibility":[115],"is":[116],"also":[117],"raised":[118],"pharmacological":[120],"agents":[121],"factors":[124],"activate":[126],"AMPK":[127],"and/or":[128],"decrease":[129],"therapeutic":[134],"targets.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
