{"id":"https://openalex.org/W1970528332","doi":"https://doi.org/10.1177/009286159502900321","title":"Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics","display_name":"Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W1970528332","doi":"https://doi.org/10.1177/009286159502900321","mag":"1970528332"},"language":"en","primary_location":{"id":"doi:10.1177/009286159502900321","doi":"https://doi.org/10.1177/009286159502900321","is_oa":false,"landing_page_url":"https://doi.org/10.1177/009286159502900321","pdf_url":null,"source":{"id":"https://openalex.org/S205840442","display_name":"Drug Information Journal","issn_l":"0092-8615","issn":["0092-8615","2164-9200"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Information Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031224690","display_name":"France Mentr\u00e9","orcid":"https://orcid.org/0000-0002-7045-1275","observed_orcids":["https://orcid.org/0000-0002-7045-1275"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405277184","display_name":"Mod\u00e9lisation math\u00e9matique et statistique en biologie et m\u00e9decine","ror":"https://ror.org/01s4pm109","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4387154366","https://openalex.org/I4405264447","https://openalex.org/I4405277184"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"France Mentr\u00e9","raw_affiliation_strings":["Department of Biostatistics, INSERM U436, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, INSERM U436, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405277184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073722339","display_name":"Pascale Burtin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pascale Burtin","raw_affiliation_strings":["Drug Safety, Sandoz Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety, Sandoz Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005190059","display_name":"Yann Merl\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405277184","display_name":"Mod\u00e9lisation math\u00e9matique et statistique en biologie et m\u00e9decine","ror":"https://ror.org/01s4pm109","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4387154366","https://openalex.org/I4405264447","https://openalex.org/I4405277184"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Merl\u00e9","raw_affiliation_strings":["Department of Biostatistics, INSERM U436, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, INSERM U436, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405277184"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joost van Bree","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Joost van Bree","raw_affiliation_strings":["Drug Safety, Sandoz Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety, Sandoz Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113541799","display_name":"Alain Mallet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405277184","display_name":"Mod\u00e9lisation math\u00e9matique et statistique en biologie et m\u00e9decine","ror":"https://ror.org/01s4pm109","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4387154366","https://openalex.org/I4405264447","https://openalex.org/I4405277184"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Mallet","raw_affiliation_strings":["Department of Biostatistics, INSERM U436, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, INSERM U436, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405277184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111832231","display_name":"Jean\u2010Louis Steimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Louis Steimer","raw_affiliation_strings":["Drug Safety, Sandoz Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety, Sandoz Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I4388891806"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4918,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91161653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"29","issue":"3","first_page":"997","last_page":"1019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.2361000031232834,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8289999961853027},{"id":"https://openalex.org/keywords/toxicokinetics","display_name":"toxicokinetics","score":1.0},{"id":"https://openalex.org/keywords/population-based-approach","display_name":"population approach","score":0.7770000100135803},{"id":"https://openalex.org/keywords/d-optimality","display_name":"D-optimality","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fisher-information-matrix","display_name":"Fisher information matrix","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bayesian-experimental-design","display_name":"Bayesian experimental design","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mixed-effects-models","display_name":"mixed models","score":0.5879999995231628},{"id":"https://openalex.org/keywords/nonlinear-regression","display_name":"nonlinear regression","score":0.574999988079071},{"id":"https://openalex.org/keywords/sampling-time-optimization","display_name":"sampling time optimization","score":0.6610000133514404},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6211690902709961},{"id":"https://openalex.org/C104409967","wikidata":"https://www.wikidata.org/wiki/Q1054836","display_name":"Homoscedasticity","level":3,"score":0.5880417227745056},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.579014778137207},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.53709876537323},{"id":"https://openalex.org/C29406490","wikidata":"https://www.wikidata.org/wiki/Q1420659","display_name":"Fisher information","level":2,"score":0.5277310609817505},{"id":"https://openalex.org/C186394612","wikidata":"https://www.wikidata.org/wiki/Q7098942","display_name":"Optimal design","level":2,"score":0.5205115675926208},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4838646650314331},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.4757232964038849},{"id":"https://openalex.org/C101104100","wikidata":"https://www.wikidata.org/wiki/Q1063540","display_name":"Heteroscedasticity","level":2,"score":0.46426132321357727},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.45979639887809753},{"id":"https://openalex.org/C75373757","wikidata":"https://www.wikidata.org/wiki/Q7410160","display_name":"Sampling design","level":3,"score":0.4366990029811859},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.4230383038520813},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4012828767299652},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/009286159502900321","doi":"https://doi.org/10.1177/009286159502900321","is_oa":false,"landing_page_url":"https://doi.org/10.1177/009286159502900321","pdf_url":null,"source":{"id":"https://openalex.org/S205840442","display_name":"Drug Information Journal","issn_l":"0092-8615","issn":["0092-8615","2164-9200"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Information Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W186908251","https://openalex.org/W1967484508","https://openalex.org/W1993147091","https://openalex.org/W1993445853","https://openalex.org/W1995504484","https://openalex.org/W1996262066","https://openalex.org/W2005168502","https://openalex.org/W2005931745","https://openalex.org/W2007049364","https://openalex.org/W2017826290","https://openalex.org/W2026243710","https://openalex.org/W2036650141","https://openalex.org/W2039534486","https://openalex.org/W2045949646","https://openalex.org/W2049558150","https://openalex.org/W2049633694","https://openalex.org/W2050005887","https://openalex.org/W2057808899","https://openalex.org/W2059185356","https://openalex.org/W2082807246","https://openalex.org/W2102904779","https://openalex.org/W2110229208","https://openalex.org/W2116661400","https://openalex.org/W2116903249","https://openalex.org/W2117913875","https://openalex.org/W2126010502","https://openalex.org/W2144578442","https://openalex.org/W2328032908","https://openalex.org/W2615953416","https://openalex.org/W2886126771","https://openalex.org/W3041034414","https://openalex.org/W3042367336","https://openalex.org/W3103871524","https://openalex.org/W4247798650"],"related_works":["https://openalex.org/W2068712300","https://openalex.org/W2795837398","https://openalex.org/W1566325672","https://openalex.org/W2103201248","https://openalex.org/W2069463518","https://openalex.org/W2076724474","https://openalex.org/W2072378612","https://openalex.org/W2072361894","https://openalex.org/W1968004121","https://openalex.org/W7096663058"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
