{"id":"https://openalex.org/W1970491990","doi":"https://doi.org/10.1186/scrt77","title":"Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin","display_name":"Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin","publication_year":2011,"publication_date":"2011-08-30","ids":{"openalex":"https://openalex.org/W1970491990","doi":"https://doi.org/10.1186/scrt77","mag":"1970491990","pmid":"https://pubmed.ncbi.nlm.nih.gov/21878106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219067"},"language":"en","primary_location":{"id":"doi:10.1186/scrt77","doi":"https://doi.org/10.1186/scrt77","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt77","pdf_url":"https://link.springer.com/content/pdf/10.1186/scrt77.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/scrt77.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084092831","display_name":"Michael P. Demars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P Demars","raw_affiliation_strings":["Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 808 S Wood St, Rm, 572 Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 808 S Wood St, Rm, 572 Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112803953","display_name":"Amelia M. Bartholomew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia Bartholomew","raw_affiliation_strings":["Department of Surgery, The University of Illinois at Chicago, 840 S Wood St. Suite 402, Chicago, IL, 60612, USA","Department of Surgery, The University of Illinois at Chicago, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The University of Illinois at Chicago, 840 S Wood St. Suite 402, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Surgery, The University of Illinois at Chicago, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037471037","display_name":"Zuzana Strakov\u00e1","orcid":"https://orcid.org/0000-0001-5219-3287","observed_orcids":["https://orcid.org/0000-0001-5219-3287"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuzana Strakova","raw_affiliation_strings":["Department of Obstetrics and Gynecology College of Medicine, The University of Illinois at Chicago, 1801 W. Taylor Street, Chicago, IL, 60612, USA","Department of Obstetrics and Gynecology College of Medicine, The University of Illinois at Chicago, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology College of Medicine, The University of Illinois at Chicago, 1801 W. Taylor Street, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology College of Medicine, The University of Illinois at Chicago, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046974464","display_name":"Orly Lazarov","orcid":"https://orcid.org/0000-0002-5887-948X","observed_orcids":["https://orcid.org/0000-0002-5887-948X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Orly Lazarov","raw_affiliation_strings":["Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 808 S Wood St. Rm. 572, Chicago, IL, 60612, USA","Department of Anatomy and Cell Biology, The University of Illinois at Chicago, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 808 S Wood St. Rm. 572, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, The University of Illinois at Chicago, Chicago, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046974464"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.6246,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.90153734,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2","issue":"4","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.23469999432563782,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sappalpha","display_name":"sAPP\u03b1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/alpha-secretase","display_name":"alpha-secretase","score":0.843999981880188},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"subventricular zone","score":0.8949999809265137},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6534578204154968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6366913318634033},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.632208526134491},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.575583815574646},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5683783888816833},{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.5294660329818726},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.5217569470405579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5028631091117859},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.473084032535553},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.44308334589004517},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4100160002708435},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3809489905834198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3791518807411194},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3784869313240051},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.26254886388778687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18683964014053345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18213382363319397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08863750100135803},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004475","descriptor_name":"Ectoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/scrt77","doi":"https://doi.org/10.1186/scrt77","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt77","pdf_url":"https://link.springer.com/content/pdf/10.1186/scrt77.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3219067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:21878106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21878106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/10780217","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Soluble_amyloid_precursor_protein_a_novel_proliferation_factor_of_adult_progenitor_cells_of_ectodermal_and_mesodermal_origin/10780217","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/scrt77","doi":"https://doi.org/10.1186/scrt77","is_oa":true,"landing_page_url":"https://doi.org/10.1186/scrt77","pdf_url":"https://link.springer.com/content/pdf/10.1186/scrt77.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4724024520","display_name":"Plasticity circuits in Alzheimer s disease","funder_award_id":"R01AG033570","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5975065137","display_name":null,"funder_award_id":"AG033570","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306153","display_name":"Brain Research Foundation","ror":"https://ror.org/0492gsr48"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320322896","display_name":"Australian Dental Research Foundation","ror":"https://ror.org/026h3kw78"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970491990.pdf","grobid_xml":"https://content.openalex.org/works/W1970491990.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1487852103","https://openalex.org/W1507460091","https://openalex.org/W1596272559","https://openalex.org/W1598870275","https://openalex.org/W1599737625","https://openalex.org/W1783111952","https://openalex.org/W1806803216","https://openalex.org/W1933062072","https://openalex.org/W1968900405","https://openalex.org/W1971256323","https://openalex.org/W1977570151","https://openalex.org/W1983283587","https://openalex.org/W1996066783","https://openalex.org/W1996511362","https://openalex.org/W1999625021","https://openalex.org/W2003682134","https://openalex.org/W2009994144","https://openalex.org/W2019427919","https://openalex.org/W2019500453","https://openalex.org/W2030355018","https://openalex.org/W2030892371","https://openalex.org/W2036058710","https://openalex.org/W2036430534","https://openalex.org/W2038516967","https://openalex.org/W2040170596","https://openalex.org/W2041622179","https://openalex.org/W2045080708","https://openalex.org/W2045861063","https://openalex.org/W2049172071","https://openalex.org/W2055561480","https://openalex.org/W2056181922","https://openalex.org/W2065437319","https://openalex.org/W2066789184","https://openalex.org/W2082326701","https://openalex.org/W2103267380","https://openalex.org/W2131717731","https://openalex.org/W2132810311","https://openalex.org/W2134720588","https://openalex.org/W2150596288","https://openalex.org/W2167400765","https://openalex.org/W2169152986","https://openalex.org/W2412029491","https://openalex.org/W2808875217","https://openalex.org/W2906916700"],"related_works":["https://openalex.org/W2292262777","https://openalex.org/W2030355018","https://openalex.org/W2049486987","https://openalex.org/W7099570340","https://openalex.org/W1599737625","https://openalex.org/W2073509870","https://openalex.org/W7101099677","https://openalex.org/W2091604559","https://openalex.org/W2167015592","https://openalex.org/W2168940259"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Soluble":[1],"amyloid":[2],"precursor":[3],"protein":[4],"\u03b1":[5],"(sAPP\u03b1)":[6],"is":[7,44,203],"a":[8,32,41,51,81,181,204,225,240,297,312,319,335],"proteolyte":[9],"of":[10,17,24,31,34,38,59,68,74,112,132,136,149,167,183,207,214,219,237,245,248,254,280,293,303,323,326],"APP":[11,75,150,168],"cleavage":[12,19],"by":[13,116,140,161,193,234],"\u03b1-secretase.":[14],"The":[15],"significance":[16],"the":[18,21,35,57,65,71,119,156,235,255,290],"and":[20,89,103,123,129,151,164,171,177,187,211,263,275,282,317,328],"physiological":[22,313],"role":[23,79,298],"sAPP\u03b1":[25,39,55,88,202,238,251,281,300,316,339],"are":[26,286],"unknown.":[27],"A":[28],"crystal":[29],"structure":[30],"region":[33],"amino":[36],"terminal":[37],"reveals":[40],"domain":[42],"that":[43,77,201],"similar":[45],"to":[46],"cysteine-rich":[47],"growth":[48,82,260,266],"factors.":[49],"While":[50],"previous":[52],"study":[53],"implicates":[54],"in":[56,64,94,155,175,189,224,239,270,289,301,305],"regulation":[58,302],"neural":[60,95],"progenitor":[61,96,324],"cell":[62,222,229],"proliferation":[63,124,137,205,218,230,257,321],"subventricular":[66,157,291],"zone":[67,158,292],"adult":[69,208,294],"mice,":[70,295],"ubiquitous":[72],"expression":[73,179],"suggests":[76],"its":[78,152],"as":[80,180],"factor":[83,206,261,267,322],"might":[84],"be":[85,232],"broader.":[86],"METHODS:":[87],"\u03b1-secretase":[90,113,215],"activities":[91],"were":[92,191],"determined":[93,126,160,192],"cells":[97,101,109,143,325],"(NPCs),":[98],"mesenchymal":[99],"stem":[100,108,221],"(MSC)":[102],"human":[104],"decidua":[105],"parietalis":[106],"placenta":[107],"(hdPSC).":[110],"Inhibition":[111,213],"was":[114,125,138,159],"achieved":[115,139],"treatment":[117],"with":[118,144,272],"matrixmetalloproteinase":[120],"inhibitor":[121],"GM6001,":[122],"using":[127],"clonogenic":[128],"immunocytochemical":[130],"analysis":[131],"cell-lineage":[133],"markers.":[134],"Recovery":[135],"supplementing":[141],"GM6001-treated":[142],"recombinant":[145],"soluble":[146,184],"APP\u03b1.":[147],"Expression":[148],"cellular":[153],"localization":[154],"Western":[162,194],"blot":[163,195],"immunohistochemical":[165],"analyses":[166],"wild":[169],"type":[170],"knockout":[172],"tissue.":[173],"Alterations":[174],"pERK":[176],"pAKT":[178],"function":[182,314],"APP\u03b1":[185],"production":[186],"activity":[188,216],"NPCs":[190,304],"analysis.":[196],"RESULTS:":[197],"Here":[198],"we":[199],"show":[200],"NPCs,":[209],"MSCs":[210],"hdpPSC.":[212],"reduces":[217],"these":[220],"populations":[223],"dose-dependent":[226,241],"manner.":[227],"Stem":[228],"can":[231],"recovered":[233],"addition":[236],"manner,":[242],"but":[243,269],"not":[244],"media":[246],"depleted":[247],"sAPP\u03b1.":[249],"Importantly,":[250],"operates":[252],"independently":[253],"prominent":[256],"factors":[258],"epidermal":[259],"(EGF)":[262],"basic":[264],"fibroblast":[265],"(bFGF),":[268],"association":[271],"ERK":[273],"signaling":[274,277,340],"MAP-kinase":[276],"pathways.":[278],"Levels":[279],"putative":[283],"\u03b1-secretase,":[284],"ADAM10,":[285],"particularly":[287],"high":[288],"suggesting":[296],"for":[299,315,338],"this":[306],"microenvironment.":[307],"CONCLUSIONS:":[308],"These":[309],"results":[310],"determine":[311],"identify":[318],"new":[320],"ectodermal":[327],"mesodermal":[329],"origin.":[330],"Further,":[331],"our":[332],"studies":[333],"elucidate":[334],"potential":[336],"pathway":[337],"through":[341],"MAP":[342],"kinase":[343],"activation.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}