{"id":"https://openalex.org/W1970490262","doi":"https://doi.org/10.1210/jc.2006-1139","title":"Midkine, a Heparin-Binding Growth Factor, Selectively Stimulates Proliferation of Definitive Zone Cells of the Human Fetal Adrenal Gland","display_name":"Midkine, a Heparin-Binding Growth Factor, Selectively Stimulates Proliferation of Definitive Zone Cells of the Human Fetal Adrenal Gland","publication_year":2006,"publication_date":"2006-08-09","ids":{"openalex":"https://openalex.org/W1970490262","doi":"https://doi.org/10.1210/jc.2006-1139","mag":"1970490262","pmid":"https://pubmed.ncbi.nlm.nih.gov/16895951"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2006-1139","doi":"https://doi.org/10.1210/jc.2006-1139","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-1139","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007378556","display_name":"Hitoshi Ishimoto","orcid":"https://orcid.org/0009-0006-5581-2278","observed_orcids":["https://orcid.org/0009-0006-5581-2278"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Ishimoto","raw_affiliation_strings":["Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences (H.I., R.B.J.) San Francisco, California 94143","Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences (H.I., R.B.J.) San Francisco, California 94143","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054159016","display_name":"Marcus O. Muench","orcid":"https://orcid.org/0000-0001-8946-6605","observed_orcids":["https://orcid.org/0000-0001-8946-6605"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus O. Muench","raw_affiliation_strings":["Department of Laboratory Medicine (M.O.M.), University of California at San Francisco, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine (M.O.M.), University of California at San Francisco, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takayuki Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Higuchi","raw_affiliation_strings":["Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110031490","display_name":"Kazuhiro Minegishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Minegishi","raw_affiliation_strings":["Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048351946","display_name":"Mamoru Tanaka","orcid":"https://orcid.org/0000-0002-1782-4271","observed_orcids":["https://orcid.org/0000-0002-1782-4271"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Tanaka","raw_affiliation_strings":["Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110095838","display_name":"Yasunori Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Yoshimura","raw_affiliation_strings":["Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (H.I., T.H., K.M., M.T., Y.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073525642","display_name":"Robert B. Jaffe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert B. Jaffe","raw_affiliation_strings":["Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences (H.I., R.B.J.) San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences (H.I., R.B.J.) San Francisco, California 94143","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073525642"],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.4495,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81729207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"91","issue":"10","first_page":"4050","last_page":"4056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.08100000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/midkine","display_name":"midkine","score":1.0},{"id":"https://openalex.org/keywords/fetal-adrenal-gland","display_name":"fetal adrenal gland","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fetal-zone","display_name":"fetal zone","score":0.7099999785423279},{"id":"https://openalex.org/keywords/heparin-binding-growth-factors","display_name":"heparin-binding growth factors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/acth-regulation","display_name":"ACTH regulation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mapk-kinase","display_name":"MAPK kinase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adrenal-gland-development","display_name":"adrenal development","score":0.7559999823570251},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7185477018356323},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7178972959518433},{"id":"https://openalex.org/C158074577","wikidata":"https://www.wikidata.org/wiki/Q14907402","display_name":"Midkine","level":4,"score":0.5977839827537537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5291412472724915},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5285543203353882},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.506883442401886},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4748402237892151},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4557187259197235},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44891342520713806},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39790666103363037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20759567618370056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18956947326660156},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09296676516532898},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.07948976755142212},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078792","descriptor_name":"Midkine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2006-1139","doi":"https://doi.org/10.1210/jc.2006-1139","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-1139","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:16895951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16895951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2328042403","display_name":"Fetal Stem Cell Gene Therapy","funder_award_id":"K01DK059301","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3434567874","display_name":"Roles of midkine, a heparin-binding growth factor, in the fetal adrenal gland","funder_award_id":"17591150","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8031354179","display_name":"\u7d30\u80de\u5c64\u9078\u629e\u7684\u767a\u73fe\u86cb\u767d\u306e\u6a5f\u80fd\u89e3\u6790\u306b\u3088\u308b\u30d2\u30c8\u80ce\u5150\u526f\u814e\u5c64\u5f62\u6210\u6a5f\u69cb\u306e\u89e3\u660e","funder_award_id":"18659313","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G937007206","display_name":null,"funder_award_id":"HD-08478","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W151207798","https://openalex.org/W1484889680","https://openalex.org/W1499847165","https://openalex.org/W1519500732","https://openalex.org/W1967960775","https://openalex.org/W1979973525","https://openalex.org/W1981562447","https://openalex.org/W1982828974","https://openalex.org/W1985317756","https://openalex.org/W1987860847","https://openalex.org/W1994691713","https://openalex.org/W2009742890","https://openalex.org/W2014388753","https://openalex.org/W2014424488","https://openalex.org/W2019291050","https://openalex.org/W2021128909","https://openalex.org/W2027624328","https://openalex.org/W2034477126","https://openalex.org/W2048035500","https://openalex.org/W2048325444","https://openalex.org/W2052877163","https://openalex.org/W2056953039","https://openalex.org/W2065533226","https://openalex.org/W2068976391","https://openalex.org/W2070039198","https://openalex.org/W2074274229","https://openalex.org/W2079064153","https://openalex.org/W2085092441","https://openalex.org/W2087867186","https://openalex.org/W2091711061","https://openalex.org/W2114130634","https://openalex.org/W2117100874","https://openalex.org/W2132923246","https://openalex.org/W2134454524","https://openalex.org/W2135197741"],"related_works":["https://openalex.org/W2034279291","https://openalex.org/W2083296412","https://openalex.org/W1982828974","https://openalex.org/W2085092441","https://openalex.org/W1963847861","https://openalex.org/W2152295819","https://openalex.org/W2111463583","https://openalex.org/W2052983798","https://openalex.org/W1979973525","https://openalex.org/W1020992383"],"abstract_inverted_index":{"CONTEXT:":[0],"In":[1,187],"the":[2,8,19,28,73,168,260,263,272],"human":[3],"fetal":[4,10,157],"adrenal":[5,90],"gland":[6],"(HFA),":[7],"inner":[9],"zone":[11,22],"(FZ)":[12],"secretes":[13],"dehydroepiandrosterone":[14],"sulfate.":[15],"The":[16,56,97],"function":[17],"of":[18,33,36,40,58,70,174,195],"outer":[20],"definitive":[21],"(DZ)":[23],"is":[24,31,47],"less":[25],"clear;":[26],"however,":[27],"DZ":[29,176,205,254,273],"phenotype":[30],"that":[32,203],"a":[34,48,241],"reservoir":[35],"progenitor":[37],"cells,":[38],"many":[39],"which":[41],"are":[42],"mitotically":[43],"active.":[44],"Midkine":[45],"(MK)":[46],"heparin-binding":[49],"growth":[50,191],"factor":[51,192],"with":[52],"various":[53],"bioactivities.":[54],"OBJECTIVE:":[55],"objective":[57],"this":[59],"study":[60],"was":[61,165],"to":[62,154],"investigate":[63],"expression,":[64],"proliferative":[65,116],"effects,":[66],"and":[67,80,88,118,128,151,158,216,274],"ACTH":[68,129,220],"regulation":[69,130],"MK":[71,102,110,115,138,163,171,224,238],"in":[72,145,156,233,244,249,265,268],"HFA.":[74,169],"DESIGN":[75],"AND":[76],"SETTING:":[77],"RNA,":[78],"cryosections,":[79],"primary":[81],"cell":[82,206],"cultures":[83],"from":[84,197],"HFAs":[85],"(14-24":[86],"wk)":[87],"adult":[89,146,159],"RNA":[91],"were":[92,101,141,152],"used.":[93],"MAIN":[94],"OUTCOME":[95],"MEASURES:":[96],"main":[98],"outcome":[99],"measures":[100],"mRNA":[103,139,225],"levels":[104,140,155],"(measured":[105,112,120,131],"by":[106,113,121,132,211,226],"quantitative":[107,133],"real-time":[108,134],"RT-PCR);":[109],"localization":[111],"immunostaining);":[114],"effects":[117,252],"mechanism":[119,261],"proliferation":[122,173,194,207],"assays,":[123],"flow":[124],"cytometry,":[125],"pharmacological":[126],"interventions);":[127],"RT-PCR).":[135],"RESULTS:":[136],"HFA":[137,245],"4-fold":[142],"higher":[143],"than":[144],"adrenals":[147],"(P":[148],"<":[149,185,231],"0.05)":[150],"comparable":[153],"brains":[160],"(positive":[161],"controls).":[162],"immunoreactivity":[164],"abundant":[166],"throughout":[167],"Exogenous":[170],"caused":[172],"isolated":[175,234],"cells":[177,181,196,255],"but":[178],"not":[179],"FZ":[180,235],"(72":[182],"h,":[183,229],"P":[184,230],"0.05).":[186],"contrast,":[188],"basic":[189],"fibroblast":[190],"induced":[193],"both":[198],"zones.":[199],"Pharmacological":[200],"interventions":[201],"indicated":[202],"MK-induced":[204],"may":[208,256],"be":[209],"mediated":[210],"phosphatidylinositol":[212],"3-kinase,":[213],"MAPK":[214],"kinase,":[215],"Src":[217],"family":[218],"kinases.":[219],"(1":[221],"nm)":[222],"increased":[223],"3.5-fold":[227],"(48":[228],"0.01)":[232],"cells.":[236],"CONCLUSIONS:":[237],"likely":[239],"plays":[240],"key":[242],"role":[243],"development.":[246],"MK's":[247],"selective":[248],"vitro":[250],"mitotic":[251,269],"on":[253],"provide":[257],"insights":[258],"into":[259],"underlying":[262],"distinct":[264],"vivo":[266],"differences":[267],"activity":[270],"between":[271],"FZ.":[275]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}