{"id":"https://openalex.org/W1970442912","doi":"https://doi.org/10.1007/s00216-010-4477-y","title":"Mathematical model for determining the binding constants between immunoglobulins, bivalent ligands, and monovalent ligands","display_name":"Mathematical model for determining the binding constants between immunoglobulins, bivalent ligands, and monovalent ligands","publication_year":2010,"publication_date":"2010-12-15","ids":{"openalex":"https://openalex.org/W1970442912","doi":"https://doi.org/10.1007/s00216-010-4477-y","mag":"1970442912","pmid":"https://pubmed.ncbi.nlm.nih.gov/21161645"},"language":"en","primary_location":{"id":"doi:10.1007/s00216-010-4477-y","doi":"https://doi.org/10.1007/s00216-010-4477-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00216-010-4477-y","pdf_url":null,"source":{"id":"https://openalex.org/S18188872","display_name":"Analytical and Bioanalytical Chemistry","issn_l":"1618-2642","issn":["1618-2642","1618-2650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and Bioanalytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046538564","display_name":"Eric T. Mack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric T. Mack","raw_affiliation_strings":["BP Biofuels, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BP Biofuels, Berkeley, CA 94720, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029133213","display_name":"L. J. Cummings","orcid":"https://orcid.org/0000-0002-7783-2126","observed_orcids":["https://orcid.org/0000-0002-7783-2126"]},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Cummings","raw_affiliation_strings":["Department of Mathematical Sciences, New Jersey Institute of Technology (NJIT), Newark, NJ, 07102, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, New Jersey Institute of Technology (NJIT), Newark, NJ, 07102, USA","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048191691","display_name":"Raquel Perez\u2010Castillejos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raquel Perez-Castillejos","raw_affiliation_strings":["Department of Biomedical Engineering, NJIT, Newark, NJ, 07102, USA","Department of Electrical and Computer Engineering, NJIT, Newark, NJ, 07102, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, NJIT, Newark, NJ, 07102, USA","institution_ids":["https://openalex.org/I118118575"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, NJIT, Newark, NJ, 07102, USA","institution_ids":["https://openalex.org/I118118575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048191691"],"corresponding_institution_ids":["https://openalex.org/I118118575"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.2986,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78820701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"399","issue":"4","first_page":"1641","last_page":"1652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-binding","display_name":"immunoglobulin binding","score":0.8820000290870667},{"id":"https://openalex.org/keywords/binding-constant","display_name":"binding constant","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bivalent-ligands","display_name":"bivalent ligands","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ligand-aggregation","display_name":"ligand aggregation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/binding-isotherms","display_name":"binding isotherms","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.38600000739097595},{"id":"https://openalex.org/keywords/antibody-antigen-interaction","display_name":"antigen-antibody reaction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/receptor-ligand-complex","display_name":"receptor-ligand complex","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.9397356510162354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6887080669403076},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.406019926071167},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18708309531211853},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.08517274260520935}],"mesh":[{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00216-010-4477-y","doi":"https://doi.org/10.1007/s00216-010-4477-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00216-010-4477-y","pdf_url":null,"source":{"id":"https://openalex.org/S18188872","display_name":"Analytical and Bioanalytical Chemistry","issn_l":"1618-2642","issn":["1618-2642","1618-2650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and Bioanalytical Chemistry","raw_type":"journal-article"},{"id":"pmid:21161645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21161645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical and bioanalytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W310366126","https://openalex.org/W1518407096","https://openalex.org/W1520434148","https://openalex.org/W1555718279","https://openalex.org/W1964272884","https://openalex.org/W1984291472","https://openalex.org/W1997857545","https://openalex.org/W2001394491","https://openalex.org/W2015004365","https://openalex.org/W2023306911","https://openalex.org/W2033564865","https://openalex.org/W2036611814","https://openalex.org/W2040009592","https://openalex.org/W2049670976","https://openalex.org/W2059435741","https://openalex.org/W2064733033","https://openalex.org/W2066091036","https://openalex.org/W2069941324","https://openalex.org/W2072660673","https://openalex.org/W2087948499","https://openalex.org/W2126818937","https://openalex.org/W4253067835","https://openalex.org/W4299579020"],"related_works":["https://openalex.org/W2055602486","https://openalex.org/W1964213186","https://openalex.org/W3145448109","https://openalex.org/W2416026290","https://openalex.org/W135617201","https://openalex.org/W4384697751","https://openalex.org/W1990880840","https://openalex.org/W2077387235","https://openalex.org/W2061731390","https://openalex.org/W2023306911"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}