{"id":"https://openalex.org/W1970384704","doi":"https://doi.org/10.1097/00007890-199905150-00455","title":"VPYRRO/NO, A SELECTIVE NITRIC OXIDE DONOR TO THE LIVER, IMPROVES HEPATIC HEMODYNAMICS AND FUNCTION.","display_name":"VPYRRO/NO, A SELECTIVE NITRIC OXIDE DONOR TO THE LIVER, IMPROVES HEPATIC HEMODYNAMICS AND FUNCTION.","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1970384704","doi":"https://doi.org/10.1097/00007890-199905150-00455","mag":"1970384704"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199905150-00455","doi":"https://doi.org/10.1097/00007890-199905150-00455","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199905150-00455","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011298071","display_name":"Rocco Ricciardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Ricciardi","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111559295","display_name":"Steven H. Quarfordt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. H. Quarfordt","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081270035","display_name":"Jose E. Saavedra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. E. Saavedra","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069348197","display_name":"Larry K. Keefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. K. Keefer","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060565487","display_name":"David P. Foley","orcid":"https://orcid.org/0000-0002-0491-7006","observed_orcids":["https://orcid.org/0000-0002-0491-7006"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. P. Foley","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. A. Wheeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. A. Wheeler","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111412177","display_name":"William C. Meyers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. C. Meyers","raw_affiliation_strings":["Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcester, MA, and National Cancer Institute, Frederick Cancer Research and Development Center*, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069348197","https://openalex.org/A5081270035"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12583001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"9","first_page":"S650","last_page":"S650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazeniumdiolates","display_name":"diazeniumdiolates","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hepatic-hemodynamics","display_name":"hepatic hemodynamics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/portal-vein-pressure","display_name":"portal pressure","score":0.8479999899864197},{"id":"https://openalex.org/keywords/intrahepatic-vascular-resistance","display_name":"hepatic vascular resistance","score":0.9369999766349792},{"id":"https://openalex.org/keywords/biliary-function","display_name":"biliary function","score":0.5370000004768372},{"id":"https://openalex.org/keywords/cold-ischemia","display_name":"cold ischemia","score":0.6380000114440918},{"id":"https://openalex.org/keywords/liver-reperfusion","display_name":"liver reperfusion","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hepatic-arterial-blood-flow","display_name":"hepatic arterial blood flow","score":0.5419999957084656},{"id":"https://openalex.org/keywords/portal-blood-flow","display_name":"portal blood flow","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.73554927110672},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6468191146850586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5822792649269104},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.5349157452583313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4692862927913666},{"id":"https://openalex.org/C56900294","wikidata":"https://www.wikidata.org/wiki/Q7231497","display_name":"Portal venous pressure","level":4,"score":0.44207778573036194},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.43840503692626953},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4295368790626526},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.4113740921020508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3657847046852112},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36321884393692017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35512620210647583},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.20493531227111816},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199905150-00455","doi":"https://doi.org/10.1097/00007890-199905150-00455","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199905150-00455","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004594173","https://openalex.org/W3145291026","https://openalex.org/W2128926561","https://openalex.org/W1983575353","https://openalex.org/W2063088635","https://openalex.org/W2084129880","https://openalex.org/W2775253849","https://openalex.org/W2354794953","https://openalex.org/W4232879129","https://openalex.org/W7038418768"],"abstract_inverted_index":{"432":[0],"Introduction:":[1],"VPYRRO/NO,":[2,316,378],"a":[3,7,124,249,284],"diazeniumdiolate":[4],"compound,":[5],"is":[6],"selective":[8],"nitric":[9],"oxide":[10],"donor":[11],"to":[12,98,108,135,148,180,195,217,256,269,293,319,343,357,441],"the":[13,45,121,218,245,333,401,417,442],"liver.":[14],"In":[15,120],"this":[16],"study":[17],"we":[18],"determined":[19],"its'":[20],"effects":[21,443],"on":[22,62,446],"hepatic":[23,63,66,78,110,447],"hemodynamics":[24],"and":[25,30,47,82,93,144,163,206,211,265,280,404,427],"function":[26,434],"in":[27,44,96,244,252,287,332,341,348,372,400,411,416,432],"both":[28],"insitu":[29,46,122,219],"harvested":[31,50,246],"livers.":[32],"Methods:":[33],"VPYRRO/NO":[34,61,104,129,176,242,282,352,397,415,445],"was":[35,307,312,329,353,375],"infused":[36,243,313,330],"at":[37,277],"@":[38],"3\u03bcmoles/kg/h":[39],"for":[40],"ten":[41,125],"minute":[42,126],"intervals":[43],"autologous":[48],"perfused":[49],"liver":[51,123,220,247,402,433],"after":[52,405,435],"two":[53],"hours":[54],"of":[55,60,128,338,384,414,444],"cold":[56],"ischemia.":[57],"The":[58,430],"effect":[59],"hemodynamics,":[64],"i.e.":[65],"vascular":[67],"resistance":[68],"(HVR),":[69],"portal":[70,74],"vein":[71,75],"pressure":[72,85],"(PVP),":[73],"flow":[76,80],"(PVF),":[77],"artery":[79],"(HAF),":[81],"systolic":[83],"blood":[84],"(SBP),":[86],"were":[87,105,113,213],"evaluated.":[88],"Serum":[89,303],"taurocholate":[90],"(TC)":[91],"clearance":[92,306],"biliary":[94,373,425],"outputs":[95,340,426],"response":[97,342],"TC":[99,102,311,328,344,367,388,423,428],"alone":[100,389],"or":[101],"with":[103,115,315,366,377,381,387],"also":[106,421],"studied":[107],"evaluate":[109],"function.":[111],"Data":[112],"analyzed":[114],"Student's":[116],"t":[117],"Tests.":[118],"Results:":[119],"infusion":[127,177],"significantly":[130,192,214,308],"reduced":[131],"PVP":[132,210],"from":[133,146,178,193,254,267,291],"7.8":[134],"5.0":[136],"mmHg":[137,165,258],"(n":[138,150,166,183,198,259,271,297,321,360,390],"=":[139,142,151,154,167,170,184,187,199,202,227,230,237,240,260,272,298,322,325,361,391],"5,":[140,152,168,185,200,228,238,299,323],"p":[141,153,169,186,201,229,239,262,274,300,324,363,393],"0.005)":[143],"HVR":[145,212,266],"0.009":[147],"0.005":[149],"0.01).":[155],"However,":[156],"SBP":[157],"remained":[158],"relatively":[159],"constant":[160,278],"between":[161],"93.0":[162],"88":[164],"0.3).":[171],"PVF":[172,279],"rose":[173],"slightly":[174],"during":[175],"846":[179],"996":[181],"cc/min":[182,197],"0.5),":[188],"yet":[189],"HAF":[190],"increased":[191],"135":[194],"238":[196],"0.02).":[203],"After":[204],"ischemia":[205],"reperfusion":[207],"(I/R)":[208],"injury,":[209],"elevated":[215],"compared":[216,318,356,380],"(PVP:":[221],"12.6":[222],"vs.":[223,234],"8.2":[224],"mmHg,":[225],"n":[226,236],"0.008),":[231],"(HVR:":[232],"0.022":[233],"0.014,":[235],"0.013).":[241],"produced":[248,283],"significant":[250,285,409],"reduction":[251],"PVP,":[253],"10.75":[255],"7.75":[257],"4,":[261,273],"<":[263,275,301,364,394],"0.05),":[264],"0.20":[268],"0.014":[270],"0.05)":[276,365],"HAF.":[281],"increase":[286,347,371],"aqueous":[288],"bile":[289,304,339,349],"production":[290],"1.72":[292],"3.92":[294],"ml/15":[295],"mins":[296],"0.05).":[302],"acid":[305],"augmented":[309],"when":[310,327,351],"simultaneously":[314],"46%,":[317],"15%":[320],"0.007)":[326],"alone,":[331],"I/R":[334,406,418,436],"injured":[335,419],"organ.":[336],"Analysis":[337],"revealed":[345],"an":[346],"cholesterol":[350],"infused,":[354],"31":[355],"9.2":[358],"\u03bcmoles/h":[359,386],"3,":[362,392],"alone.":[368],"A":[369],"similar":[370],"phospholipid":[374],"noted":[376],"121.3,":[379],"baseline":[382],"values":[383],"33.3":[385],"0.07)":[395],"Conclusions:":[396],"reduces":[398],"PVP/HVR":[399],"before":[403],"injury":[407,437],"without":[408],"reductions":[410],"SBP.":[412],"Infusion":[413],"organ":[420],"improves":[422],"stimulated":[424],"clearance.":[429],"improvements":[431],"may":[438],"be":[439],"secondary":[440],"hemodynamics.":[448]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}