{"id":"https://openalex.org/W1970384000","doi":"https://doi.org/10.3892/ijmm.2012.1076","title":"The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats","display_name":"The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats","publication_year":2012,"publication_date":"2012-07-25","ids":{"openalex":"https://openalex.org/W1970384000","doi":"https://doi.org/10.3892/ijmm.2012.1076","mag":"1970384000","pmid":"https://pubmed.ncbi.nlm.nih.gov/22842798"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2012.1076","doi":"https://doi.org/10.3892/ijmm.2012.1076","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2012.1076","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2012.1076/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijmm.2012.1076/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101510787","display_name":"Jiahang Sun","orcid":"https://orcid.org/0000-0002-7945-0244","observed_orcids":["https://orcid.org/0000-0002-7945-0244"]},"institutions":[{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIAHANG SUN","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100828051","display_name":"Xie Chuncheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUNCHENG XIE","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431723","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0002-0236-7071","observed_orcids":["https://orcid.org/0000-0002-0236-7071"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WEI LIU","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100828052","display_name":"Dunyue Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DUNYUE LU","raw_affiliation_strings":["Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, State University of New York, Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003208959","display_name":"Weidong Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WEIDONG QIAO","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035464207","display_name":"Qi Huang","orcid":"https://orcid.org/0000-0003-2179-0892","observed_orcids":["https://orcid.org/0000-0003-2179-0892"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QI HUANG","raw_affiliation_strings":["Department of Anatomy, Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064621337","display_name":"Zhihui Huo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHIHUI HUO","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078585011","display_name":"Hong Shen","orcid":"https://orcid.org/0000-0002-2160-4650","observed_orcids":["https://orcid.org/0000-0002-2160-4650"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HONG SHEN","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020425588","display_name":"Zhiguo Lin","orcid":"https://orcid.org/0000-0002-2920-4272","observed_orcids":["https://orcid.org/0000-0002-2920-4272"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHIGUO LIN","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China","institution_ids":["https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9969,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.7426829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"4","first_page":"739","last_page":"746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.777999997138977},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7580000162124634},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.984000027179718},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9620000123977661},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8225299119949341},{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.7930094003677368},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.7619490623474121},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.715033769607544},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6955674886703491},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.555595338344574},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.5400003790855408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5369382500648499},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.5201661586761475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42502716183662415},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3427221179008484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3249508738517761},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.23906731605529785},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.22711828351020813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20345690846443176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14964079856872559},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14268788695335388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13240420818328857},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.11022979021072388},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.08959150314331055}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.2012.1076","doi":"https://doi.org/10.3892/ijmm.2012.1076","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2012.1076","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2012.1076/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:22842798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22842798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijmm.2012.1076","doi":"https://doi.org/10.3892/ijmm.2012.1076","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2012.1076","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2012.1076/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970384000.pdf","grobid_xml":"https://content.openalex.org/works/W1970384000.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W119798858","https://openalex.org/W1513881453","https://openalex.org/W1549969043","https://openalex.org/W1564092482","https://openalex.org/W1583738526","https://openalex.org/W1699101563","https://openalex.org/W1967912613","https://openalex.org/W1974832634","https://openalex.org/W1977595948","https://openalex.org/W1981017578","https://openalex.org/W1983021935","https://openalex.org/W1985093394","https://openalex.org/W1987780398","https://openalex.org/W1991867131","https://openalex.org/W1994145042","https://openalex.org/W1994807176","https://openalex.org/W1996241894","https://openalex.org/W2001327092","https://openalex.org/W2012650310","https://openalex.org/W2013137971","https://openalex.org/W2017885661","https://openalex.org/W2027937638","https://openalex.org/W2035062031","https://openalex.org/W2043449640","https://openalex.org/W2048086967","https://openalex.org/W2048292311","https://openalex.org/W2048399408","https://openalex.org/W2058930537","https://openalex.org/W2059223526","https://openalex.org/W2060969086","https://openalex.org/W2066784307","https://openalex.org/W2070013537","https://openalex.org/W2071976811","https://openalex.org/W2072318687","https://openalex.org/W2078464821","https://openalex.org/W2083051394","https://openalex.org/W2088107588","https://openalex.org/W2090233590","https://openalex.org/W2091077399","https://openalex.org/W2091555690","https://openalex.org/W2092452930","https://openalex.org/W2096240982","https://openalex.org/W2103200506","https://openalex.org/W2103946141","https://openalex.org/W2109504418","https://openalex.org/W2123590186","https://openalex.org/W2132411546","https://openalex.org/W2134634216","https://openalex.org/W2148373221","https://openalex.org/W2154696007","https://openalex.org/W2161700412","https://openalex.org/W2162066960","https://openalex.org/W2168605285","https://openalex.org/W2211519311"],"related_works":["https://openalex.org/W2006953095","https://openalex.org/W2026366902","https://openalex.org/W2216554879","https://openalex.org/W4321368957","https://openalex.org/W1605098290","https://openalex.org/W7097244776","https://openalex.org/W2435119948","https://openalex.org/W2041709303","https://openalex.org/W2043449640","https://openalex.org/W2004896472"],"abstract_inverted_index":{"Status":[0],"epilepticus":[1],"(SE)":[2],"causes":[3],"neuronal":[4,89,177],"loss":[5],"and":[6,23,36,117,129,146,186],"apoptosis":[7,21,28,178],"by":[8,74,93,182],"inducing":[9],"several":[10],"apoptosis-regulatory":[11],"genes.":[12],"Two":[13],"such":[14],"genes,":[15],"cysteinyl":[16],"aspartate-specific":[17],"protease-3":[18],"(caspase-3),":[19],"an":[20,27],"activator,":[22],"B-cell":[24],"leukemia-2":[25],"(Bcl-2),":[26],"suppressor,":[29],"are":[30,54],"tightly":[31],"regulated":[32],"for":[33,81],"their":[34,51],"expression":[35,116,121,185],"activation.":[37],"Statins,":[38],"inhibitors":[39],"of":[40,65,71,79,96,102,132,174],"HMG-CoA":[41],"reductase,":[42],"have":[43],"been":[44],"recently":[45],"recognized":[46],"as":[47,91],"neuroprotective":[48,63,172],"drugs.":[49],"However,":[50],"underlying":[52],"mechanisms":[53],"still":[55],"unclear.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"examined":[61],"the":[62,100,103,123,133,165,171],"effects":[64,173],"simvastatin":[66,80,162,175],"in":[67,122],"a":[68],"rat":[69,134],"model":[70],"SE":[72,110,139],"induced":[73],"kainic":[75],"acid":[76],"(KA).":[77],"Feeding":[78],"3":[82],"days":[83],"after":[84],"kainate":[85],"injection":[86],"rescued":[87],"SE-induced":[88,167],"apoptosis,":[90],"determined":[92],"histological":[94],"examination":[95],"brain":[97],"sections":[98],"at":[99,148],"level":[101],"dorsal":[104],"hippocampus.":[105,124],"Semi-quantitative":[106],"RT-PCR":[107],"showed":[108],"that":[109,137,170],"treatment":[111],"markedly":[112],"increased":[113,145],"caspase-3":[114,141,184],"mRNA":[115,120],"reduced":[118],"Bcl-2":[119,152,188],"Similarly,":[125],"western":[126],"blot":[127],"analysis":[128,131],"immunohistochemical":[130],"hippocampus":[135],"demonstrated":[136],"under":[138],"treatment,":[140],"protein":[142,153],"levels":[143,154],"significantly":[144],"peaked":[147],"72":[149],"h,":[150],"whereas":[151],"decreased":[155],"from":[156],"6-24":[157],"h":[158],"following":[159],"SE.":[160],"Interestingly,":[161],"could":[163],"reverse":[164],"aforementioned":[166],"changes,":[168],"suggesting":[169],"against":[176],"may":[179],"be":[180],"achieved":[181],"inhibiting":[183],"increasing":[187],"expression.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}