{"id":"https://openalex.org/W1970379934","doi":"https://doi.org/10.1210/jcem.78.4.8157720","title":"Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women","display_name":"Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W1970379934","doi":"https://doi.org/10.1210/jcem.78.4.8157720","mag":"1970379934","pmid":"https://pubmed.ncbi.nlm.nih.gov/8157720"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.78.4.8157720","doi":"https://doi.org/10.1210/jcem.78.4.8157720","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.78.4.8157720","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001966341","display_name":"Anne B. Loucks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Loucks","raw_affiliation_strings":["Department of Biological Sciences, Ohio University, Athens 45701-2979"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ohio University, Athens 45701-2979","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109874804","display_name":"Edward M. Heath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E M Heath","raw_affiliation_strings":["Department of Biological Sciences, Ohio University, Athens 45701-2979"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ohio University, Athens 45701-2979","institution_ids":["https://openalex.org/I4210106879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106879"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.4874,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.95159866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"78","issue":"4","first_page":"910","last_page":"915"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-calorie-diet","display_name":"hypocaloric diet","score":0.9800000190734863},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lh-pulsatility","display_name":"LH pulsatility","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lh-pulse-frequency","display_name":"LH pulse frequency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lh-pulse-amplitude","display_name":"LH pulse amplitude","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.9049999713897705},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9399999976158142},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.578000009059906},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.7919999957084656},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/energy-availability","display_name":"energy availability","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.753000020980835},{"id":"https://openalex.org/keywords/menstrual-cycle","display_name":"menstrual cycle","score":0.781000018119812},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8464405536651611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8068337440490723},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6541731357574463},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6234655380249023},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.5422698855400085},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.505467414855957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44174355268478394},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.42359796166419983},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.42084386944770813},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.41997548937797546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3545148968696594},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07273319363594055},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005526","descriptor_name":"Food, Formulated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008598","descriptor_name":"Menstruation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.78.4.8157720","doi":"https://doi.org/10.1210/jcem.78.4.8157720","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.78.4.8157720","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.78.4.910","doi":"https://doi.org/10.1210/jc.78.4.910","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.78.4.910","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8157720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8157720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1441101669","display_name":null,"funder_award_id":"1R55-HD-29547-01","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7700656868","display_name":"ENERGY AND EXERCISE--EFFECTS ON REPRODUCTIVE FUNCTION","funder_award_id":"1r55hd029547-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8743965113","display_name":"General Clinical Research Center","funder_award_id":"M01RR000034","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W215055391","https://openalex.org/W1853323522","https://openalex.org/W1870010919","https://openalex.org/W1880023255","https://openalex.org/W1971674050","https://openalex.org/W1975398215","https://openalex.org/W1979101917","https://openalex.org/W1980861659","https://openalex.org/W1988941899","https://openalex.org/W1988947995","https://openalex.org/W1989667491","https://openalex.org/W1996025707","https://openalex.org/W2004945873","https://openalex.org/W2011527482","https://openalex.org/W2019362177","https://openalex.org/W2021868940","https://openalex.org/W2029900147","https://openalex.org/W2044151079","https://openalex.org/W2049291623","https://openalex.org/W2057137264","https://openalex.org/W2058697479","https://openalex.org/W2058746698","https://openalex.org/W2059022302","https://openalex.org/W2060417855","https://openalex.org/W2069518512","https://openalex.org/W2077660175","https://openalex.org/W2086452829","https://openalex.org/W2092206211","https://openalex.org/W2092809578","https://openalex.org/W2095347664","https://openalex.org/W2108319568","https://openalex.org/W2127634307","https://openalex.org/W2133086673","https://openalex.org/W2159101625","https://openalex.org/W2162104581","https://openalex.org/W2214790450","https://openalex.org/W2342162656","https://openalex.org/W2411692281","https://openalex.org/W2415589442"],"related_works":["https://openalex.org/W4308135550","https://openalex.org/W2057490855","https://openalex.org/W2974678766","https://openalex.org/W1918596072","https://openalex.org/W4387360876","https://openalex.org/W1986918960","https://openalex.org/W2122671650","https://openalex.org/W2130807942","https://openalex.org/W2470802528","https://openalex.org/W2075928570"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,60,65,119,125,205],"effect":[3],"of":[4,46,67,121,127],"dietary":[5,69,130],"energy":[6,70,212],"restriction":[7,131],"on":[8,40,118],"gonadotropins,":[9],"we":[10],"assayed":[11,99],"LH":[12,156,176,190,208],"and":[13,20,64,98,105,114,146,168],"FSH":[14,160],"in":[15,53,83,110,214,219],"samples":[16,54,111],"drawn":[17],"at":[18,56,74,95,115],"10-":[19],"60-min":[21],"intervals,":[22],"respectively,":[23],"over":[24],"24":[25],"h":[26,97],"from":[27],"seven":[28],"young":[29],"women":[30],"(mean":[31],"+/-":[32,37],"SE":[33],"gynecological":[34],"age,":[35],"7.7":[36],"1.2":[38],"yr)":[39],"day":[41,66,120,126],"9,":[42],"10,":[43],"or":[44,77],"11":[45],"two":[47],"menstrual":[48],"cycles.":[49],"Cortisol":[50],"was":[51,72,92,108,179,193],"measured":[52,109],"collected":[55,112],"30-min":[57],"intervals.":[58],"During":[59],"4":[61],"previous":[62],"days":[63,88],"sampling,":[68,129],"intake":[71],"set":[73],"either":[75],"45":[76],"10":[78],"Cal/kg":[79],"lean":[80],"body":[81],"mass.day":[82],"random":[84],"order.":[85],"Beginning":[86],"2":[87],"before":[89],"treatment,":[90],"blood":[91],"sampled":[93],"daily":[94,113],"0800":[96],"for":[100,155],"T3,":[101],"insulin-like":[102,139],"growth":[103,140],"factor-I,":[104],"insulin.":[106],"Estradiol":[107],"6-h":[116],"intervals":[117],"frequent":[122,128],"sampling.":[123],"By":[124],"had":[132],"reduced":[133,180],"T3":[134],"20%":[135],"(P":[136,143,149,157,161,165,170,182,196],"<":[137,144,150,183],"0.01),":[138,184],"factor-I":[141],"58%":[142],"0.001),":[145],"insulin":[147],"54%":[148],"0.001).":[151],"Twenty-four-hour":[152],"transverse":[153],"means":[154],"=":[158,162,166,171,197],"0.3),":[159,167],"0.2),":[163],"estradiol":[164],"cortisol":[169],"0.13)":[172],"were":[173],"unaffected,":[174],"but":[175],"pulse":[177,191],"frequency":[178],"23%":[181],"especially":[185,199],"during":[186,200],"waking":[187],"hours,":[188],"whereas":[189],"amplitude":[192],"increased":[194],"40%":[195],"0.05),":[198],"sleep.":[201],"These":[202],"results":[203],"support":[204],"hypothesis":[206],"that":[207],"pulsatility":[209],"depends":[210],"upon":[211],"availability":[213],"women,":[215],"as":[216],"it":[217],"does":[218],"other":[220],"mammalian":[221],"species.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}