{"id":"https://openalex.org/W1970308775","doi":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","title":"Neurotoxicity in Dopamine and 5\u2010Hydroxytryptamine Terminal Fields: A Regional Analysis in Nigrostriatal and Mesolimbic Projections","display_name":"Neurotoxicity in Dopamine and 5\u2010Hydroxytryptamine Terminal Fields: A Regional Analysis in Nigrostriatal and Mesolimbic Projections","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W1970308775","doi":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","mag":"1970308775","pmid":"https://pubmed.ncbi.nlm.nih.gov/3059922"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1988.tb42104.x","doi":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111691188","display_name":"Lewis S. Seiden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. S. SEIDEN","raw_affiliation_strings":["Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637","Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057260403","display_name":"Deborah Commins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. COMMINS","raw_affiliation_strings":["Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031304754","display_name":"Georgetta L. Vosmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. VOSMER","raw_affiliation_strings":["Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033681775","display_name":"Karen J. Axt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. AXT","raw_affiliation_strings":["Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004332028","display_name":"Gerard J. Marek","orcid":"https://orcid.org/0000-0001-8103-4306","observed_orcids":["https://orcid.org/0000-0001-8103-4306"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. MAREK","raw_affiliation_strings":["Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111691188"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.7483,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.62704843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"537","issue":"1","first_page":"161","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.2280000001192093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.6439999938011169},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mesolimbic-pathway","display_name":"mesolimbic system","score":0.984000027179718},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.996999979019165},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.45899999141693115},{"id":"https://openalex.org/keywords/oxygen-availability","display_name":"oxygen availability","score":0.6119999885559082},{"id":"https://openalex.org/keywords/serotonergic-synapse","display_name":"serotonergic synapse","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dopaminergic-synapse","display_name":"dopaminergic synapse","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7784860134124756},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7527502775192261},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7203150391578674},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7019820809364319},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6505143046379089},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.600803554058075},{"id":"https://openalex.org/C2776355744","wikidata":"https://www.wikidata.org/wiki/Q4318555","display_name":"Nigrostriatal pathway","level":5,"score":0.528886079788208},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4555146098136902},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.35084113478660583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28283798694610596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15696224570274353},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13178080320358276},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1988.tb42104.x","doi":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1988.tb42104.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:3059922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3059922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1969249644","https://openalex.org/W1973570892","https://openalex.org/W1975635801","https://openalex.org/W1980648157","https://openalex.org/W1980765757","https://openalex.org/W1981290467","https://openalex.org/W1982531318","https://openalex.org/W1984508889","https://openalex.org/W1984782469","https://openalex.org/W1996066498","https://openalex.org/W1996668453","https://openalex.org/W2000233275","https://openalex.org/W2012055211","https://openalex.org/W2014162693","https://openalex.org/W2028974167","https://openalex.org/W2032950110","https://openalex.org/W2044595141","https://openalex.org/W2046055371","https://openalex.org/W2047944520","https://openalex.org/W2051573571","https://openalex.org/W2056157611","https://openalex.org/W2058758107","https://openalex.org/W2061589525","https://openalex.org/W2066214697","https://openalex.org/W2071922989","https://openalex.org/W2076922712","https://openalex.org/W2083680902","https://openalex.org/W2089851074","https://openalex.org/W2090811746","https://openalex.org/W2107541352","https://openalex.org/W2149330955","https://openalex.org/W2154313452","https://openalex.org/W2163145678","https://openalex.org/W2246813284","https://openalex.org/W2253242458","https://openalex.org/W2264173921","https://openalex.org/W2266953608","https://openalex.org/W2410175368","https://openalex.org/W2773060000","https://openalex.org/W4231906956","https://openalex.org/W4300570220"],"related_works":["https://openalex.org/W1984782469","https://openalex.org/W1984582808","https://openalex.org/W2012055211","https://openalex.org/W2065619339","https://openalex.org/W3020595643","https://openalex.org/W2076922712","https://openalex.org/W1211550181","https://openalex.org/W7099775237","https://openalex.org/W1969757403","https://openalex.org/W1693348571"],"abstract_inverted_index":{"In":[0,35],"summary,":[1],"we":[2,16],"have":[3,17],"shown":[4],"that":[5,21,68],"MA":[6,115],"is":[7,116],"toxic":[8,112],"to":[9,33,60,91,110,122,129],"both":[10],"5-HT":[11,74,87,106],"and":[12,15,85,107,135,139],"DA":[13,40,93,108],"cells":[14],"proposed":[18],"a":[19],"mechanism":[20],"would":[22],"account":[23],"for":[24,100],"this":[25,101],"response,":[26],"namely,":[27],"the":[28,31,64,81,86,92,105,111,123,130],"conversion":[29],"of":[30,39,66,104,114,126,133],"transmitters":[32],"neurotoxins.":[34],"addition,":[36],"brain":[37],"depletions":[38,46],"seem":[41,59],"regionally":[42],"specific":[43],"with":[44],"larger":[45],"occurring":[47],"in":[48,52,80],"some":[49],"areas":[50],"than":[51],"others.":[53],"The":[54,98],"depletions,":[55,88,94],"however,":[56],"do":[57],"not":[58],"depend":[61],"entirely":[62],"on":[63],"nuclei":[65],"origin,":[67],"is,":[69],"substantia":[70],"nigra":[71],"versus":[72],"VTA.":[73],"was":[75],"depleted":[76],"by":[77],"different":[78],"amounts":[79],"various":[82],"regions":[83],"examined":[84],"although":[89],"proportional":[90],"were":[95],"consistently":[96],"greater.":[97],"reasons":[99],"differential":[102,124],"sensitivity":[103],"systems":[109],"effect":[113],"speculative,":[117],"but":[118],"may":[119],"be":[120],"related":[121],"formation":[125],"toxins":[127],"due":[128],"differing":[131],"availability":[132],"oxygen":[134],"superoxides":[136],"at":[137],"serotonergic":[138],"dopaminergic":[140],"synapses.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}