{"id":"https://openalex.org/W1970296705","doi":"https://doi.org/10.1074/jbc.m705575200","title":"Extracellular Signal-regulated Kinase Regulation of Tumor Necrosis Factor-\u03b1 mRNA Nucleocytoplasmic Transport Requires TAP-NxT1 Binding and the AU-rich Element","display_name":"Extracellular Signal-regulated Kinase Regulation of Tumor Necrosis Factor-\u03b1 mRNA Nucleocytoplasmic Transport Requires TAP-NxT1 Binding and the AU-rich Element","publication_year":2007,"publication_date":"2007-11-30","ids":{"openalex":"https://openalex.org/W1970296705","doi":"https://doi.org/10.1074/jbc.m705575200","mag":"1970296705","pmid":"https://pubmed.ncbi.nlm.nih.gov/18048358"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m705575200","doi":"https://doi.org/10.1074/jbc.m705575200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705575200","pdf_url":"http://www.jbc.org/article/S0021925820697812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820697812/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen J. Skinner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Skinner","raw_affiliation_strings":["Veterans Affairs Medical Center, White River Junction, Vermont 05009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center, White River Junction, Vermont 05009","institution_ids":["https://openalex.org/I4210118357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084561147","display_name":"Kristen M. Deleault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen M. Deleault","raw_affiliation_strings":["Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033694061","display_name":"Ryan E. Fecteau","orcid":"https://orcid.org/0000-0002-3744-2924","observed_orcids":["https://orcid.org/0000-0002-3744-2924"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Fecteau","raw_affiliation_strings":["Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113671090","display_name":"Seth A. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seth A. Brooks","raw_affiliation_strings":["Veterans Affairs Medical Center, White River Junction, Vermont 05009; Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756; Department of Microbiology and Immunology, Dartmouth College, Lebanon, New Hampshire 03756. Electronic address: seth.brooks@dartmouth.edu","Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756","Department of Microbiology and Immunology, Dartmouth College, Lebanon, New Hampshire 03756","Veterans Affairs Medical Center, White River Junction, Vermont 05009"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center, White River Junction, Vermont 05009; Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756; Department of Microbiology and Immunology, Dartmouth College, Lebanon, New Hampshire 03756. Electronic address: seth.brooks@dartmouth.edu","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I4210118357"]},{"raw_affiliation_string":"Department of Medicine, Dartmouth Medical School, Dartmouth College, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Dartmouth College, Lebanon, New Hampshire 03756","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, White River Junction, Vermont 05009","institution_ids":["https://openalex.org/I4210118357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113671090"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I4210118357"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.588,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.80968429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"283","issue":"6","first_page":"3191","last_page":"3199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mrna-export","display_name":"mRNA export","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9480000138282776},{"id":"https://openalex.org/keywords/au-rich-elements","display_name":"AU-rich elements","score":0.9049999713897705},{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.824999988079071},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tristetraprolin","display_name":"tristetraprolin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.375}],"concepts":[{"id":"https://openalex.org/C2909367411","wikidata":"https://www.wikidata.org/wiki/Q18032413","display_name":"Tristetraprolin","level":5,"score":0.8927589654922485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6325417757034302},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.6271788477897644},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5989665985107422},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5670262575149536},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5563098788261414},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49527397751808167},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49139726161956787},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4631843566894531},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44349709153175354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42956724762916565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3843381404876709},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35605472326278687},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.352843701839447},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3317226469516754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21141871809959412},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.20441541075706482},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08185794949531555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07790029048919678}],"mesh":[{"descriptor_ui":"D000067780","descriptor_name":"ELAV-Like Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071181","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029543","descriptor_name":"Nucleocytoplasmic Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051816","descriptor_name":"Tristetraprolin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051959","descriptor_name":"ELAV Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m705575200","doi":"https://doi.org/10.1074/jbc.m705575200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705575200","pdf_url":"http://www.jbc.org/article/S0021925820697812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18048358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18048358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m705575200","doi":"https://doi.org/10.1074/jbc.m705575200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m705575200","pdf_url":"http://www.jbc.org/article/S0021925820697812/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970296705.pdf","grobid_xml":"https://content.openalex.org/works/W1970296705.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W9714344","https://openalex.org/W49625740","https://openalex.org/W1528910009","https://openalex.org/W1550722396","https://openalex.org/W1591157507","https://openalex.org/W1624405189","https://openalex.org/W1650996792","https://openalex.org/W1868478050","https://openalex.org/W1955386538","https://openalex.org/W1964201687","https://openalex.org/W1969108518","https://openalex.org/W1973967947","https://openalex.org/W1982925662","https://openalex.org/W1986938385","https://openalex.org/W1992938326","https://openalex.org/W2001192666","https://openalex.org/W2004751481","https://openalex.org/W2005100774","https://openalex.org/W2008340390","https://openalex.org/W2008605645","https://openalex.org/W2011409010","https://openalex.org/W2016776106","https://openalex.org/W2030688800","https://openalex.org/W2037038996","https://openalex.org/W2039077632","https://openalex.org/W2039081691","https://openalex.org/W2040391070","https://openalex.org/W2042852292","https://openalex.org/W2045714098","https://openalex.org/W2046530526","https://openalex.org/W2047142238","https://openalex.org/W2058580739","https://openalex.org/W2068054277","https://openalex.org/W2069727672","https://openalex.org/W2070073216","https://openalex.org/W2073711665","https://openalex.org/W2075901029","https://openalex.org/W2078950285","https://openalex.org/W2084084328","https://openalex.org/W2084564714","https://openalex.org/W2091694934","https://openalex.org/W2096932850","https://openalex.org/W2097095148","https://openalex.org/W2107363136","https://openalex.org/W2107807571","https://openalex.org/W2116410320","https://openalex.org/W2116898709","https://openalex.org/W2122814011","https://openalex.org/W2123531867","https://openalex.org/W2127457813","https://openalex.org/W2127551467","https://openalex.org/W2131428840","https://openalex.org/W2134692718","https://openalex.org/W2137302306","https://openalex.org/W2142940299","https://openalex.org/W2145322004","https://openalex.org/W2146681915","https://openalex.org/W2146838928","https://openalex.org/W2146963242","https://openalex.org/W2151778247","https://openalex.org/W2154325818","https://openalex.org/W2155127403","https://openalex.org/W2156744692","https://openalex.org/W2162322742","https://openalex.org/W2165626613","https://openalex.org/W2166206156","https://openalex.org/W2168384341","https://openalex.org/W2174322658"],"related_works":["https://openalex.org/W1974066524","https://openalex.org/W2016776106","https://openalex.org/W2160604432","https://openalex.org/W2148814680","https://openalex.org/W2129649868","https://openalex.org/W2001192666","https://openalex.org/W2047142238","https://openalex.org/W2078810064","https://openalex.org/W2058435956","https://openalex.org/W7161981474"],"abstract_inverted_index":{"Tumor":[0],"necrosis":[1],"factor-alpha":[2],"(TNF-alpha)":[3],"production":[4],"is":[5,46,151,158,175,185],"regulated":[6,49],"by":[7,178],"transcriptional":[8],"and":[9,31,55,88,107,134,141],"posttranscriptional":[10],"mechanisms.":[11],"Lipopolysaccharide":[12,20],"activates":[13,22],"the":[14,23,35,43,52,57,60,71,77,82,85,101,125,139,169],"NFkappaB":[15],"pathway":[16,54],"increasing":[17],"TNF-alpha":[18,36,44,61,72,78,114,130,154],"transcription.":[19],"also":[21,81],"mitogen-activated":[24],"protein":[25],"kinase":[26],"pathways,":[27],"resulting":[28],"in":[29,95],"stabilization":[30],"enhanced":[32],"translation":[33],"of":[34,42,59,70,84,91,98,103,113,127],"message.":[37],"In":[38],"addition,":[39],"nuclear":[40,68,116],"export":[41,69,117],"mRNA":[45,115,155],"a":[47],"posttranscriptionally":[48],"process":[50],"involving":[51],"Tpl2-ERK":[53],"requiring":[56],"presence":[58],"AU-rich":[62],"element":[63],"(ARE).":[64],"We":[65],"demonstrate":[66,145],"that":[67,111,136,146],"message":[73],"requires":[74],"not":[75],"only":[76,182],"ARE":[79],"but":[80],"interaction":[83],"proteins":[86],"TAP":[87],"NxT1,":[89],"both":[90],"which":[92],"are":[93],"involved":[94],"nucleocytoplasmic":[96],"transport":[97],"mRNA.":[99],"Through":[100],"use":[102],"dominant":[104],"negative":[105],"ERK1":[106],"ERK2,":[108],"we":[109,123],"establish":[110],"control":[112],"operates":[118],"specifically":[119],"through":[120],"ERK1.":[121],"Finally,":[122],"examined":[124],"role":[126],"two":[128],"established":[129],"ARE-binding":[131,164],"proteins,":[132],"HuR":[133,150],"tristetraprolin,":[135],"shuttle":[137],"between":[138],"nucleus":[140],"cytoplasm.":[142],"These":[143],"data":[144],"neither":[147],"tristetraprolin":[148],"nor":[149],"required":[152],"for":[153],"export.":[156],"It":[157],"unclear":[159],"at":[160],"this":[161],"time":[162],"if":[163,172,181],"protein(s)":[165],"directly":[166],"interact":[167],"with":[168],"TAP-NxT1":[170],"complex,":[171],"each":[173],"complex":[174,184],"independently":[176],"targeted":[177],"ERK1,":[179],"or":[180],"one":[183],"targeted.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
