{"id":"https://openalex.org/W1970232007","doi":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","title":"Totalsynthese des marinen Naturstoffs 7-Desoxyokadas\u00e4ure, eines starken Inhibitors der Serin/Threonin-spezifischen Proteinphosphatasen","display_name":"Totalsynthese des marinen Naturstoffs 7-Desoxyokadas\u00e4ure, eines starken Inhibitors der Serin/Threonin-spezifischen Proteinphosphatasen","publication_year":1999,"publication_date":"1999-08-02","ids":{"openalex":"https://openalex.org/W1970232007","doi":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","mag":"1970232007"},"language":"de","primary_location":{"id":"doi:10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051543310","display_name":"Amy B. Dounay","orcid":"https://orcid.org/0000-0003-0451-5549","observed_orcids":["https://orcid.org/0000-0003-0451-5549"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy B. Dounay","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA,","Department of Chemistry University of Minnesota Minneapolis, MN, 55455 (USA) Fax: (+1)\u2009612-626-7541"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Chemistry University of Minnesota Minneapolis, MN, 55455 (USA) Fax: (+1)\u2009612-626-7541","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001570077","display_name":"Rebecca A. Urbanek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Urbanek","raw_affiliation_strings":["Astra Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069030913","display_name":"Steven F. Sabes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven F. Sabes","raw_affiliation_strings":["Shionogi Bio Research Corp., 45 Hartwell Ave., Lexington, MA 02173, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shionogi Bio Research Corp., 45 Hartwell Ave., Lexington, MA 02173, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053073891","display_name":"Craig J. Forsyth","orcid":"https://orcid.org/0000-0003-0836-8187","observed_orcids":["https://orcid.org/0000-0003-0836-8187"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig J. Forsyth","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA,","Department of Chemistry University of Minnesota Minneapolis, MN, 55455 (USA) Fax: (+1)\u2009612-626-7541"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Chemistry University of Minnesota Minneapolis, MN, 55455 (USA) Fax: (+1)\u2009612-626-7541","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053073891"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.07246175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"111","issue":"15","first_page":"2403","last_page":"2406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.274399995803833,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.9440000057220459},{"id":"https://openalex.org/keywords/protein-phosphatase-inhibitors","display_name":"protein phosphatase inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/conformation","display_name":"conformation","score":0.5059999823570251},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8439438343048096},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3715808093547821}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","doi":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.0.co;2-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.3.co;2-z","doi":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.3.co;2-z","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1521-3757(19990802)111:15<2403::aid-ange2403>3.3.co;2-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.8899999856948853,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W195587516","https://openalex.org/W1516949595","https://openalex.org/W1527047098","https://openalex.org/W1564912721","https://openalex.org/W1749352888","https://openalex.org/W1855390275","https://openalex.org/W1960573418","https://openalex.org/W1966645093","https://openalex.org/W1983526542","https://openalex.org/W1987174568","https://openalex.org/W1998305107","https://openalex.org/W2006905701","https://openalex.org/W2009456056","https://openalex.org/W2009706617","https://openalex.org/W2010089028","https://openalex.org/W2015141841","https://openalex.org/W2022729618","https://openalex.org/W2026846652","https://openalex.org/W2031799240","https://openalex.org/W2034998855","https://openalex.org/W2040726375","https://openalex.org/W2042377147","https://openalex.org/W2044132788","https://openalex.org/W2053857580","https://openalex.org/W2055081241","https://openalex.org/W2057755142","https://openalex.org/W2058659013","https://openalex.org/W2071801044","https://openalex.org/W2078674830","https://openalex.org/W2084022730","https://openalex.org/W2088377461","https://openalex.org/W2119361029","https://openalex.org/W2139776813","https://openalex.org/W2215536036","https://openalex.org/W2314795980","https://openalex.org/W2349550891","https://openalex.org/W2950673812","https://openalex.org/W2951445213"],"related_works":["https://openalex.org/W1973440293","https://openalex.org/W2952935023","https://openalex.org/W4240528156","https://openalex.org/W6924719877","https://openalex.org/W2043303241","https://openalex.org/W205452484","https://openalex.org/W74657801","https://openalex.org/W4251821607","https://openalex.org/W2340205775","https://openalex.org/W2324088487"],"abstract_inverted_index":{"Eine":[0],"nur":[1],"kleine":[2],"Ver\u00e4nderung":[3],"an":[4,14],"der":[5,12,31,40],"Struktur":[6],"von":[7,27,32],"Okadas\u00e4ure":[8],"1,":[9],"das":[10],"Fehlen":[11],"Hydroxygruppe":[13],"C7,":[15],"f\u00fchrt":[16],"zum":[17],"pr\u00e4parativ":[18],"erheblich":[19],"besser":[20],"zug\u00e4nglichen":[21],"Derivat":[22],"7-Desoxyokadas\u00e4ure":[23],"2.":[24],"Die":[25],"Konformation":[26],"2":[28],"stimmt":[29],"mit":[30],"1":[33],"\u00fcberein,":[34],"und":[35,44],"die":[36],"Wirkung":[37],"als":[38],"Inhibitor":[39],"Serin/Threonin-spezifischen":[41],"Proteinphosphatasen":[42],"PP-1":[43],"PP-2A":[45],"wird,":[46],"wie":[47],"k\u00fcrzlich":[48],"berichtet":[49],"wurde,":[50],"durch":[51],"diese":[52],"minimale":[53],"Strukturvariation":[54],"kaum":[55],"beeinflu\u00dft.":[56]},"counts_by_year":[{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}