{"id":"https://openalex.org/W1970225644","doi":"https://doi.org/10.1074/jbc.m700821200","title":"Acute Lung Injury Edema Fluid Decreases Net Fluid Transport across Human Alveolar Epithelial Type II Cells","display_name":"Acute Lung Injury Edema Fluid Decreases Net Fluid Transport across Human Alveolar Epithelial Type II Cells","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W1970225644","doi":"https://doi.org/10.1074/jbc.m700821200","mag":"1970225644","pmid":"https://pubmed.ncbi.nlm.nih.gov/17580309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765119"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m700821200","doi":"https://doi.org/10.1074/jbc.m700821200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700821200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m700821200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100415738","display_name":"Jae Wook Lee","orcid":"https://orcid.org/0000-0002-8756-0195","observed_orcids":["https://orcid.org/0000-0002-8756-0195","https://orcid.org/0009-0003-5670-1586"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jae W. Lee","raw_affiliation_strings":["Department of Anesthesiology, University of California, San Francisco, CA 94143, USA. leejw@anesthesia.ucsf.edu","Department of Anesthesiology and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of California, San Francisco, CA 94143, USA. leejw@anesthesia.ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anesthesiology and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668570","display_name":"Xiaohui Fang","orcid":"https://orcid.org/0000-0003-2731-5021","observed_orcids":["https://orcid.org/0000-0003-2731-5021"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Fang","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056039332","display_name":"Gregory Dolganov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Dolganov","raw_affiliation_strings":["Department of Medicine, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071823966","display_name":"Richard D. Fremont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Fremont","raw_affiliation_strings":["Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046756619","display_name":"Julie A. Bastarache","orcid":"https://orcid.org/0000-0003-0458-6507","observed_orcids":["https://orcid.org/0000-0003-0458-6507"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Bastarache","raw_affiliation_strings":["Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017253129","display_name":"Lorraine B. Ware","orcid":"https://orcid.org/0000-0002-9429-4702","observed_orcids":["https://orcid.org/0000-0002-9429-4702"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine B. Ware","raw_affiliation_strings":["Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, California","Department of Anesthesiology and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anesthesiology and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100415738"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4193,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.78609228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"282","issue":"33","first_page":"24109","last_page":"24119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":1.0},{"id":"https://openalex.org/keywords/alveolar-fluid-clearance","display_name":"alveolar fluid clearance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.9070000052452087},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.8379999995231628},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2909420118","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar Epithelium","level":3,"score":0.7371090054512024},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.697371244430542},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.6807911396026611},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5718265771865845},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5639692544937134},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.48408687114715576},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.45667359232902527},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4101458787918091},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4078027009963989},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3487921953201294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3480457067489624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3450774550437927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3285788893699646},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.2529143691062927},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.18892896175384521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10895705223083496},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10851547122001648},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m700821200","doi":"https://doi.org/10.1074/jbc.m700821200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700821200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17580309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17580309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2765119","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2765119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m700821200","doi":"https://doi.org/10.1074/jbc.m700821200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700821200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3429402575","display_name":null,"funder_award_id":"HL-51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G375247153","display_name":"RESOLUTION OF CLINICAL LUNG INJURY","funder_award_id":"R01HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8055508284","display_name":"Lung Fluid Balance and Mesenchymal Stem Cells","funder_award_id":"R01HL051854","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8256553738","display_name":"Biomarker Profiles in the Diagnosis/Prognosis of ARDS","funder_award_id":"U01HL081332","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G904655290","display_name":"Resolution of Clinical Lung Injury","funder_award_id":"R37HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1482266658","https://openalex.org/W1566010084","https://openalex.org/W1842750594","https://openalex.org/W1964665576","https://openalex.org/W1967429254","https://openalex.org/W1976830450","https://openalex.org/W1986296119","https://openalex.org/W1989880837","https://openalex.org/W1991940875","https://openalex.org/W2001674978","https://openalex.org/W2005357317","https://openalex.org/W2005401154","https://openalex.org/W2012121490","https://openalex.org/W2016168978","https://openalex.org/W2028422283","https://openalex.org/W2040596758","https://openalex.org/W2065044742","https://openalex.org/W2068854215","https://openalex.org/W2075430896","https://openalex.org/W2079127109","https://openalex.org/W2085137108","https://openalex.org/W2087957246","https://openalex.org/W2088483450","https://openalex.org/W2089817272","https://openalex.org/W2091029415","https://openalex.org/W2093431893","https://openalex.org/W2093852073","https://openalex.org/W2097665403","https://openalex.org/W2098799051","https://openalex.org/W2110707896","https://openalex.org/W2112652405","https://openalex.org/W2113633128","https://openalex.org/W2119483908","https://openalex.org/W2123992594","https://openalex.org/W2134906082","https://openalex.org/W2141818933","https://openalex.org/W2143766390","https://openalex.org/W2144304154","https://openalex.org/W2146880780","https://openalex.org/W2151502323","https://openalex.org/W2151556390","https://openalex.org/W2151630650","https://openalex.org/W2152280553","https://openalex.org/W2158310716","https://openalex.org/W2159052610","https://openalex.org/W2161328469","https://openalex.org/W2170653875","https://openalex.org/W2171647107","https://openalex.org/W2172201608","https://openalex.org/W2184627546","https://openalex.org/W2241461566","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W2079894038","https://openalex.org/W2118044708","https://openalex.org/W2781800723","https://openalex.org/W7100608395","https://openalex.org/W2084161778","https://openalex.org/W2373049922","https://openalex.org/W2119483908","https://openalex.org/W2829452514","https://openalex.org/W2075430896","https://openalex.org/W7073580844"],"abstract_inverted_index":{"Most":[0],"patients":[1,42,191],"with":[2,16,43,141,192,217],"acute":[3],"lung":[4],"injury":[5],"(ALI)":[6],"have":[7],"reduced":[8,127],"alveolar":[9,27,63,130,187,208,227],"fluid":[10,28,40,56,124,139,168,171,189,223],"clearance":[11],"that":[12,37,121,214],"has":[13],"been":[14],"associated":[15,216],"higher":[17],"mortality.":[18],"Several":[19],"mechanisms":[20],"may":[21],"contribute":[22],"to":[23,70,135],"the":[24,35,47,75,80,108,163,166,181],"decrease":[25,219],"in":[26,58,198,206,220],"clearance.":[29],"In":[30,106,185],"this":[31],"study,":[32],"we":[33],"tested":[34],"hypothesis":[36],"pulmonary":[38,72,137],"edema":[39,73,138,167,188],"from":[41,190],"ALI":[44,71,136,193],"might":[45],"reduce":[46],"expression":[48,179],"of":[49,61,94,156,165,180],"ion":[50,183],"transport":[51,57,85,125,172,202,224],"genes":[52,86,203],"responsible":[53],"for":[54,79,112,128],"vectorial":[55,123,222],"primary":[59],"cultures":[60],"human":[62,129,207,226],"epithelial":[64,209],"type":[65,131,210,228],"II":[66,132,211,229],"cells.":[67],"Following":[68],"exposure":[69],"fluid,":[74],"gene":[76,109,176],"copy":[77,110],"number":[78,111],"major":[81],"sodium":[82,199],"and":[83,97,177,200,204],"chloride":[84,201],"decreased.":[87],"By":[88],"Western":[89],"blot":[90],"analyses,":[91],"protein":[92,178],"levels":[93],"alphaENaC,":[95],"alpha1Na,K-ATPase,":[96],"cystic":[98],"fibrosis":[99],"transmembrane":[100],"conductance":[101],"regulator":[102],"decreased":[103],"as":[104,173,175],"well.":[105],"contrast,":[107],"several":[113],"inflammatory":[114],"cytokines":[115],"increased":[116],"markedly.":[117],"Functional":[118],"studies":[119],"demonstrated":[120],"net":[122,170,221],"was":[126],"cells":[133],"exposed":[134],"compared":[140],"plasma":[142],"(0.02":[143],"+/-":[144,148],"0.05":[145],"versus":[146],"1.31":[147],"0.56":[149],"microl/cm2/h,":[150],"p":[151],"<":[152],"0.02).":[153],"An":[154],"inhibitor":[155],"p38":[157],"MAPK":[158],"phosphorylation":[159],"(SB202190)":[160],"partially":[161],"reversed":[162],"effects":[164,213],"on":[169],"well":[174],"main":[182],"transporters.":[184],"summary,":[186],"induced":[194],"a":[195,218],"significant":[196],"reduction":[197],"proteins":[205],"cells,":[212],"were":[215],"across":[225],"cell":[230],"monolayers.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
