{"id":"https://openalex.org/W1970224616","doi":"https://doi.org/10.1093/carcin/19.2.359","title":"Characterization of the carcinogen 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline in cooking aerosols under domestic conditions","display_name":"Characterization of the carcinogen 2-amino-3,8-dimethylimidazo[4,5- f]quinoxaline in cooking aerosols under domestic conditions","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1970224616","doi":"https://doi.org/10.1093/carcin/19.2.359","mag":"1970224616","pmid":"https://pubmed.ncbi.nlm.nih.gov/9498289"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/19.2.359","doi":"https://doi.org/10.1093/carcin/19.2.359","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/19.2.359","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C. Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"C. Yang","raw_affiliation_strings":["Institute of Biochemistry and Toxicology, Chung Shan Medical and Dental College, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Toxicology, Chung Shan Medical and Dental College, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I91279580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91279580"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.4195,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.58580523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"2","first_page":"359","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11745","display_name":"Potato Plant Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meiqx","display_name":"MeIQx","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cooking-fumes","display_name":"cooking emissions","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta98","display_name":"Salmonella typhimurium TA98","score":0.9629999995231628},{"id":"https://openalex.org/keywords/female-lung-cancer","display_name":"female lung cancer","score":0.6899999976158142},{"id":"https://openalex.org/keywords/non-smoking-women","display_name":"non-smoking women","score":0.7680000066757202},{"id":"https://openalex.org/keywords/chinese-women","display_name":"Chinese women","score":0.5350000262260437},{"id":"https://openalex.org/keywords/mutagen-exposure","display_name":"mutagen exposure","score":0.46799999475479126},{"id":"https://openalex.org/keywords/carcinogens","display_name":"carcinogens","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.7930732369422913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.733616054058075},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.708968997001648},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6103654503822327},{"id":"https://openalex.org/C2780362310","wikidata":"https://www.wikidata.org/wiki/Q419930","display_name":"Quinoxaline","level":2,"score":0.5738075971603394},{"id":"https://openalex.org/C2779345167","wikidata":"https://www.wikidata.org/wiki/Q104541","display_name":"Aerosol","level":2,"score":0.564075231552124},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5262393355369568},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.4692290723323822},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.4361925721168518},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.36295050382614136},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.33681318163871765},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29181817173957825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1503530740737915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15023919939994812},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14147865772247314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13690143823623657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1299765408039093},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003296","descriptor_name":"Cooking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/19.2.359","doi":"https://doi.org/10.1093/carcin/19.2.359","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/19.2.359","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:9498289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9498289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1495284","https://openalex.org/W82530212","https://openalex.org/W1492157159","https://openalex.org/W1980496573","https://openalex.org/W1995834499","https://openalex.org/W2005156172","https://openalex.org/W2017177343","https://openalex.org/W2030626447","https://openalex.org/W2040511804","https://openalex.org/W2041890446","https://openalex.org/W2046479936","https://openalex.org/W2061585701","https://openalex.org/W2068699855","https://openalex.org/W2073169238","https://openalex.org/W2092688124","https://openalex.org/W2112391361","https://openalex.org/W2127321206","https://openalex.org/W2162737599","https://openalex.org/W2165661242","https://openalex.org/W2327859121","https://openalex.org/W3023622511","https://openalex.org/W3143569680","https://openalex.org/W4240474963","https://openalex.org/W4248685550"],"related_works":["https://openalex.org/W1980496573","https://openalex.org/W2044774243","https://openalex.org/W7097340487","https://openalex.org/W1999759013","https://openalex.org/W1985310667","https://openalex.org/W2258565022","https://openalex.org/W2095249932","https://openalex.org/W2003844448","https://openalex.org/W2074843769","https://openalex.org/W2056920355"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,9,23,35],"in":[2,11,49,78,138,182,185,211],"women":[3,15,38,190],"is":[4,53],"the":[5,31,46,57,60,75,79,114,139,163,212],"leading":[6],"cause":[7],"of":[8,20,33,66,88,113,117,122,151,155,172,177,206],"death":[10],"Taiwan.":[12],"Most":[13],"Chinese":[14,37,64,189],"are":[16],"non-smokers":[17],"and":[18,93,129],"60%":[19],"female":[21],"lung":[22,34],"patients":[24],"have":[25],"adenocarcinomas.":[26],"Epidemiological":[27],"data":[28,167],"indicate":[29],"that":[30,169],"incidence":[32],"among":[36],"may":[39,200],"be":[40,146,201],"correlated":[41],"with":[42,98],"cooking":[43,50,61,80,118,140,183,209],"fumes.":[44],"However,":[45],"carcinogenic":[47],"compound(s)":[48],"fume":[51],"aerosols":[52,62,210],"not":[54],"defined.":[55],"In":[56],"present":[58,181],"study,":[59],"from":[63,120,208],"stir-frying":[65],"fish":[67,123],"were":[68,83,180],"prepared":[69],"under":[70],"domestic":[71],"conditions.":[72],"To":[73],"determine":[74],"mutagenic":[76,115,136,164],"compounds":[77],"aerosol,":[81],"mutagens":[82],"purified":[84],"by":[85,126],"two":[86],"steps":[87],"high-performance":[89],"liquid":[90],"chromatography":[91],"(HPLC),":[92],"their":[94],"mutagenicity":[95],"was":[96,104,124,143,159],"monitored":[97],"Salmonella":[99],"typhimurium":[100],"TA98.":[101],"The":[102,110,133],"mutagen":[103],"eluted":[105],"as":[106],"a":[107,186],"single":[108],"peak.":[109],"chemical":[111],"structure":[112],"fraction":[116],"aerosol":[119,141,184],"frying":[121,178],"characterized":[125],"UV":[127],"spectra":[128],"electrospray":[130],"mass":[131],"spectrometry.":[132],"bacterial":[134],"indirect-acting":[135],"compound":[137],"extract":[142],"determined":[144],"to":[145,203],"2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline":[147],"(MeIQx).":[148],"An":[149],"amount":[150],"0.25":[152],"ng":[153],"MeIQx/g":[154],"meat":[156],"per":[157],"min":[158],"estimated":[160],"based":[161],"on":[162],"response.":[165],"These":[166],"indicated":[168],"significant":[170,204],"amounts":[171,205],"MeIQx":[173,207],"(268.1":[174],"ng/Chinese":[175],"dish":[176],"fish)":[179],"short":[187],"time.":[188],"spend":[191],"approximately":[192],"1":[193],"h":[194],"preparing":[195],"meals":[196],"everyday,":[197],"thus,":[198],"they":[199],"exposed":[202],"kitchen.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}