{"id":"https://openalex.org/W1970205702","doi":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","title":"Homology of DNA sequences encompassing malignant hyperthermia mutation site in the ovine (Ovis aries) and porcine (Sus scrofa) ryr1 gene","display_name":"Homology of DNA sequences encompassing malignant hyperthermia mutation site in the ovine (Ovis aries) and porcine (Sus scrofa) ryr1 gene","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W1970205702","doi":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","mag":"1970205702"},"language":"en","primary_location":{"id":"doi:10.1046/j.1439-0388.1999.00189.x","doi":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","pdf_url":null,"source":{"id":"https://openalex.org/S158490989","display_name":"Journal of Animal Breeding and Genetics","issn_l":"0044-3581","issn":["0044-3581","0931-2668","1439-0388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Breeding and Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098219517","display_name":"By P. Gronek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55783418","display_name":"Pozna\u0144 University of Life Sciences","ror":"https://ror.org/03tth1e03","country_code":"PL","type":"education","lineage":["https://openalex.org/I55783418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"By P. Gronek","raw_affiliation_strings":["Department of Pig Breeding and Production, A. Cieszkowski Agricultural University of Poznan\u0301,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pig Breeding and Production, A. Cieszkowski Agricultural University of Poznan\u0301,","institution_ids":["https://openalex.org/I55783418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084800088","display_name":"D. Napieraa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"D. Napieraa","raw_affiliation_strings":["Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,","institution_ids":["https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070526190","display_name":"Katarzyna Nuc","orcid":"https://orcid.org/0000-0001-9875-3112","observed_orcids":["https://orcid.org/0000-0001-9875-3112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Nuc","raw_affiliation_strings":["Department of Biochemistry and Biotechnology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003508312","display_name":"Ryszard Steppa","orcid":"https://orcid.org/0000-0001-9465-9612","observed_orcids":["https://orcid.org/0000-0001-9465-9612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Steppa","raw_affiliation_strings":["Department of Sheep and Goat Breeding, A. Cieszkowski Agricultural University of Poznan\u0301, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sheep and Goat Breeding, A. Cieszkowski Agricultural University of Poznan\u0301, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026892702","display_name":"Andrzej P\u0142awski","orcid":"https://orcid.org/0000-0002-0534-8941","observed_orcids":["https://orcid.org/0000-0002-0534-8941"]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"A. Plawski","raw_affiliation_strings":["Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,","institution_ids":["https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073134154","display_name":"R. S omski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"R. S!omski","raw_affiliation_strings":["Department of Biochemistry and Biotechnology and","Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology and","institution_ids":[]},{"raw_affiliation_string":"Department of Human Genetics, Polish Academy of Sciences, Poznan\u0301,","institution_ids":["https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10743862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"4","first_page":"263","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.828000009059906},{"id":"https://openalex.org/keywords/ryr1-gene","display_name":"RYR1 gene","score":0.8169999718666077},{"id":"https://openalex.org/keywords/malignant-hyperthermia","display_name":"malignant hyperthermia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ryr1-mutations","display_name":"RYR1 mutations","score":0.6129999756813049},{"id":"https://openalex.org/keywords/ovine","display_name":"ovine","score":0.5070000290870667},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/exon-17","display_name":"exon 17","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.3009999990463257}],"concepts":[{"id":"https://openalex.org/C2776333580","wikidata":"https://www.wikidata.org/wiki/Q18031340","display_name":"RYR1","level":4,"score":0.9674125909805298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7434736490249634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6236394643783569},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5783332586288452},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5479120016098022},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5302478671073914},{"id":"https://openalex.org/C2778575482","wikidata":"https://www.wikidata.org/wiki/Q1585081","display_name":"Malignant hyperthermia","level":2,"score":0.5239368081092834},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.5007085800170898},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4998664855957031},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.48737436532974243},{"id":"https://openalex.org/C2777963300","wikidata":"https://www.wikidata.org/wiki/Q22724","display_name":"Ovis","level":2,"score":0.4701433479785919},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4661463797092438},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.26376402378082275},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0775429904460907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1046/j.1439-0388.1999.00189.x","doi":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1439-0388.1999.00189.x","pdf_url":null,"source":{"id":"https://openalex.org/S158490989","display_name":"Journal of Animal Breeding and Genetics","issn_l":"0044-3581","issn":["0044-3581","0931-2668","1439-0388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Breeding and Genetics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1964768262","https://openalex.org/W1989286153","https://openalex.org/W2034044880","https://openalex.org/W2046827129","https://openalex.org/W2058293154","https://openalex.org/W2109493047","https://openalex.org/W2118094114","https://openalex.org/W2138270253","https://openalex.org/W2146717942","https://openalex.org/W2166950311"],"related_works":["https://openalex.org/W334148388","https://openalex.org/W2071597841","https://openalex.org/W2030108670","https://openalex.org/W2101092183","https://openalex.org/W963870542","https://openalex.org/W2405474639","https://openalex.org/W2022565122","https://openalex.org/W2782489191","https://openalex.org/W2992773168","https://openalex.org/W1992571150"],"abstract_inverted_index":{"The":[0,22,41],"PCR":[1],"products":[2],"of":[3,10,17,44,53],"ryr1":[4,45,56],"gene":[5,46],"amplified":[6],"from":[7,50],"genomic":[8],"DNA":[9],"Sus":[11],"scrofa":[12],"and":[13,30],"synthetic":[14],"prolific":[15],"lines":[16],"Ovis":[18],"aries":[19],"were":[20],"analysed.":[21],"polymerase":[23],"chain":[24],"reaction\u2010single":[25],"strand":[26],"conformation":[27],"polymorphism":[28],"(PCR\u2010SSCP),":[29],"sequencing":[31],"analysis":[32],"for":[33],"research":[34],"on":[35],"ovine,":[36],"ryanodine":[37],"receptor":[38],"(ryr1)":[39],"gene.":[40,57],"ovine":[42],"fragment":[43],"did":[47],"not":[48],"differ":[49],"exon":[51],"17":[52],"the":[54],"porcine":[55]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}