{"id":"https://openalex.org/W1970194166","doi":"https://doi.org/10.1097/00005768-199605001-00204","title":"EFFECTS OF AGING ON CONTRACTILITY OF SINGLE MUSCLE FIBERS: MODULATORY INFLUENCE OF PHYSICAL ACTIVITY 204","display_name":"EFFECTS OF AGING ON CONTRACTILITY OF SINGLE MUSCLE FIBERS: MODULATORY INFLUENCE OF PHYSICAL ACTIVITY 204","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1970194166","doi":"https://doi.org/10.1097/00005768-199605001-00204","mag":"1970194166"},"language":"en","primary_location":{"id":"doi:10.1097/00005768-199605001-00204","doi":"https://doi.org/10.1097/00005768-199605001-00204","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-199605001-00204","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp Science in Sports &amp Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004799706","display_name":"Walter R. Frontera","orcid":"https://orcid.org/0000-0001-8471-2248","observed_orcids":["https://orcid.org/0000-0001-8471-2248"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"W. R. Frontera","raw_affiliation_strings":["School and Spaulding Rehabilitation Hospital, Boston, MA","Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I2799748957"]},{"raw_affiliation_string":"Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I136199984","https://openalex.org/I2799748957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054810689","display_name":"X. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"X. Li","raw_affiliation_strings":["School and Spaulding Rehabilitation Hospital, Boston, MA","Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I2799748957"]},{"raw_affiliation_string":"Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I136199984","https://openalex.org/I2799748957"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059674225","display_name":"Lars Larsson","orcid":"https://orcid.org/0000-0003-3722-035X","observed_orcids":["https://orcid.org/0000-0003-3722-035X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799748957","display_name":"Spaulding Rehabilitation Hospital","ror":"https://ror.org/011dvr318","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799748957","https://openalex.org/I48633490"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"L. Larsson","raw_affiliation_strings":["School and Spaulding Rehabilitation Hospital, Boston, MA","Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I2799748957"]},{"raw_affiliation_string":"Dept. of Clin. Neurophysiology, Karolinska Hospital, Stockholm, Sweden and Dept. of Physical Medicine and Rehabilitation, Harvard Med. School and Spaulding Rehabilitation Hospital, Boston, MA","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I136199984","https://openalex.org/I2799748957"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"Supplement","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8610000014305115},{"id":"https://openalex.org/keywords/single-muscle-fibers","display_name":"single muscle fibers","score":0.7149999737739563},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/maximum-shortening-velocity","display_name":"maximum shortening velocity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.800000011920929},{"id":"https://openalex.org/keywords/type-i-muscle-fibres","display_name":"type I muscle fibers","score":0.652999997138977},{"id":"https://openalex.org/keywords/muscle-fiber-composition","display_name":"muscle fiber composition","score":0.4480000138282776},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7589789628982544},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.68756502866745},{"id":"https://openalex.org/C2776643329","wikidata":"https://www.wikidata.org/wiki/Q975459","display_name":"Vastus lateralis muscle","level":3,"score":0.6709126234054565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5003514289855957},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4990673065185547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47847530245780945},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.4448779821395874},{"id":"https://openalex.org/C2780366628","wikidata":"https://www.wikidata.org/wiki/Q21368803","display_name":"Rowing","level":2,"score":0.44126054644584656},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.42067837715148926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3655809760093689},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.2674870491027832},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16083207726478577},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00005768-199605001-00204","doi":"https://doi.org/10.1097/00005768-199605001-00204","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-199605001-00204","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp Science in Sports &amp Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979663721","https://openalex.org/W2413432844","https://openalex.org/W2319725335","https://openalex.org/W2051150389","https://openalex.org/W2044270414","https://openalex.org/W2145069786","https://openalex.org/W2239178393","https://openalex.org/W2002340827","https://openalex.org/W4243347599","https://openalex.org/W2150635375"],"abstract_inverted_index":{"The":[0,54,173,219],"purposes":[1],"of":[2,11,16,26,29,92,107,139,175],"the":[3,9,14,24,52,101,105,121,151,156,183,206,213,236],"present":[4,220],"study":[5],"were":[6,77,86],"to":[7,22],"investigate":[8],"effects":[10],"aging":[12,195],"on":[13,124],"contractility":[15],"single":[17,84],"human":[18],"muscle":[19],"fibers":[20,138,149,166,176,208],"and":[21,43,65,83,104,116,136,141,164,190],"evaluate":[23],"influence":[25],"increased":[27],"levels":[28],"physical":[30,237],"activity.":[31],"Four":[32],"young":[33],"untrained":[34,40],"(Y;":[35],"25-31":[36],"yrs),":[37],"2":[38,44],"old":[39,45,157],"(OU;":[41],"77,81),":[42],"trained":[46],"(OT;":[47],"73,74)":[48],"men":[49,56],"participated":[50],"in":[51,150,170,182,196,203,205,212,235],"study.":[53],"OT":[55,142,186],"had":[57,167],"maintained":[58],"an":[59,232],"exercise":[60],"program":[61],"including":[62],"cycling,":[63],"rowing":[64],"wrestling":[66],"at":[67],"least":[68],"3":[69],"days/week":[70],"for":[71],"more":[72,178],"than":[73,147,179,231],"50":[74],"years.":[75],"Biopsies":[76],"obtained":[78],"from":[79,120],"m.":[80],"vastus":[81],"lateralis":[82],"fibers(n=377)":[85],"membrane":[87],"permeabilized":[88],"by":[89,100,228],"glycerol":[90],"treatment":[91],"freeze-drying.":[93],"Maximum":[94],"shortening":[95],"velocity":[96],"(Vo)":[97],"was":[98,118,159,187],"measured":[99],"slack":[102],"test":[103],"composition":[106],"myosin":[108],"heavy":[109],"chain":[110],"(MyHC)":[111],"isoforms":[112],"(types":[113],"I,":[114],"IIA":[115,137],"IIB)":[117],"determined":[119],"migration":[122],"order":[123],"very":[125],"sensitive":[126],"silver-stained":[127],"6%":[128],"SDS-PAGE.":[129],"Our":[130],"results":[131,221],"show":[132],"that":[133,223],"type":[134],"I":[135],"OU":[140],"have":[143],"significantly":[144],"slower":[145],"Vo":[146,169,204],"similar":[148,168],"Y.":[152],"No":[153],"difference":[154],"between":[155],"groups":[158],"noted.":[160],"Table":[161],"Fast":[162],"IIAB":[163],"IIB":[165],"all":[171],"groups.":[172],"percentage":[174],"co-expressing":[177],"one":[180],"MHC":[181],"Y,":[184],"OU,":[185],"14%,":[188],"10%,":[189],"22%,":[191],"respectively.":[192],"In":[193],"conclusion,":[194],"humans":[197],"is":[198,226],"associated":[199],"with":[200],"a":[201],"decline":[202],"slow":[207],"as":[209],"previously":[210],"reported":[211],"rat":[214],"(Li":[215],"&":[216],"Larsson,":[217],"1995).":[218],"suggest":[222],"this":[224],"slowing":[225],"caused":[227],"mechanisms":[229],"other":[230],"age-related":[233],"decrease":[234],"activity":[238],"level.":[239]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}