{"id":"https://openalex.org/W1970163774","doi":"https://doi.org/10.1038/nrm3871","title":"Molecular mechanisms of de novo lumen formation","display_name":"Molecular mechanisms of de novo lumen formation","publication_year":2014,"publication_date":"2014-09-04","ids":{"openalex":"https://openalex.org/W1970163774","doi":"https://doi.org/10.1038/nrm3871","mag":"1970163774","pmid":"https://pubmed.ncbi.nlm.nih.gov/25186133"},"language":"en","primary_location":{"id":"doi:10.1038/nrm3871","doi":"https://doi.org/10.1038/nrm3871","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm3871","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013498209","display_name":"Sara Sigurbj\u00f6rnsd\u00f3ttir","orcid":"https://orcid.org/0000-0002-3030-8888","observed_orcids":["https://orcid.org/0000-0002-3030-8888"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara Sigurbj\u00f6rnsd\u00f3ttir","raw_affiliation_strings":["1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2]","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047691044","display_name":"Renjith Mathew","orcid":"https://orcid.org/0009-0003-2674-1288","observed_orcids":["https://orcid.org/0009-0003-2674-1288"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Renjith Mathew","raw_affiliation_strings":["1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2]","European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2]","institution_ids":["https://openalex.org/I4210138560"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012787334","display_name":"Maria Leptin","orcid":"https://orcid.org/0000-0001-7097-348X","observed_orcids":["https://orcid.org/0000-0001-7097-348X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maria Leptin","raw_affiliation_strings":["1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2] Institute of Genetics, University of Cologne, D-50674 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] European Molecular Biology Laboratory, 69117 Heidelberg, Germany. [2] Institute of Genetics, University of Cologne, D-50674 Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012787334"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210138560","https://openalex.org/I4210153543"],"apc_list":null,"apc_paid":null,"fwci":1.2401,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.77852349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"15","issue":"10","first_page":"665","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.9800000190734863},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.9100000262260437},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/drosophila-trachea","display_name":"Drosophila trachea","score":0.9110000133514404},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7992433309555054},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.678396463394165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5883693099021912},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5864839553833008},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5282914638519287},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.47549542784690857},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4586401879787445},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4496498703956604},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34943169355392456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3251931667327881},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14433589577674866},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1423577070236206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09128773212432861}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrm3871","doi":"https://doi.org/10.1038/nrm3871","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrm3871","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmid:25186133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25186133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Molecular cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:42751","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/42751/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1225109155","https://openalex.org/W1613258091","https://openalex.org/W1679562638","https://openalex.org/W1970895551","https://openalex.org/W1972204116","https://openalex.org/W1977754435","https://openalex.org/W1979371608","https://openalex.org/W1982405831","https://openalex.org/W1984042890","https://openalex.org/W1984294894","https://openalex.org/W1984715051","https://openalex.org/W1986166750","https://openalex.org/W1988902941","https://openalex.org/W1993261987","https://openalex.org/W1994532651","https://openalex.org/W1998865371","https://openalex.org/W2000529605","https://openalex.org/W2000770367","https://openalex.org/W2002911609","https://openalex.org/W2003531471","https://openalex.org/W2003649795","https://openalex.org/W2008434851","https://openalex.org/W2012198427","https://openalex.org/W2012228004","https://openalex.org/W2015256188","https://openalex.org/W2017822537","https://openalex.org/W2018440302","https://openalex.org/W2019614403","https://openalex.org/W2021649658","https://openalex.org/W2022037546","https://openalex.org/W2022731004","https://openalex.org/W2029559609","https://openalex.org/W2030214706","https://openalex.org/W2033273681","https://openalex.org/W2035108361","https://openalex.org/W2037095294","https://openalex.org/W2050297084","https://openalex.org/W2054390470","https://openalex.org/W2055410989","https://openalex.org/W2055644846","https://openalex.org/W2056535053","https://openalex.org/W2057733044","https://openalex.org/W2058468930","https://openalex.org/W2058858609","https://openalex.org/W2059034651","https://openalex.org/W2060006253","https://openalex.org/W2061308761","https://openalex.org/W2062480745","https://openalex.org/W2064386416","https://openalex.org/W2066448365","https://openalex.org/W2068215757","https://openalex.org/W2069003433","https://openalex.org/W2069354876","https://openalex.org/W2071885493","https://openalex.org/W2073038040","https://openalex.org/W2075047490","https://openalex.org/W2077742951","https://openalex.org/W2079070267","https://openalex.org/W2084938734","https://openalex.org/W2085317499","https://openalex.org/W2087109658","https://openalex.org/W2089184185","https://openalex.org/W2090526224","https://openalex.org/W2092447350","https://openalex.org/W2094033351","https://openalex.org/W2094667322","https://openalex.org/W2095466161","https://openalex.org/W2095718486","https://openalex.org/W2100537036","https://openalex.org/W2109858044","https://openalex.org/W2117876140","https://openalex.org/W2118286268","https://openalex.org/W2119314468","https://openalex.org/W2119529392","https://openalex.org/W2123787611","https://openalex.org/W2124657728","https://openalex.org/W2124739780","https://openalex.org/W2126312494","https://openalex.org/W2128480694","https://openalex.org/W2130516243","https://openalex.org/W2133848888","https://openalex.org/W2143101243","https://openalex.org/W2145742097","https://openalex.org/W2147819429","https://openalex.org/W2148474745","https://openalex.org/W2154333296","https://openalex.org/W2166943442","https://openalex.org/W2169360787","https://openalex.org/W2171768963","https://openalex.org/W2186976975","https://openalex.org/W2187905598","https://openalex.org/W6997643163","https://openalex.org/W7099755275"],"related_works":["https://openalex.org/W2982427249","https://openalex.org/W1998865371","https://openalex.org/W3094274250","https://openalex.org/W2068215757","https://openalex.org/W1994647031","https://openalex.org/W2000293396","https://openalex.org/W2126964995","https://openalex.org/W3015346348","https://openalex.org/W2567376423","https://openalex.org/W2043099950"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}