{"id":"https://openalex.org/W1970146933","doi":"https://doi.org/10.1002/cne.20709","title":"Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse","display_name":"Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1970146933","doi":"https://doi.org/10.1002/cne.20709","mag":"1970146933","pmid":"https://pubmed.ncbi.nlm.nih.gov/16175558"},"language":"en","primary_location":{"id":"doi:10.1002/cne.20709","doi":"https://doi.org/10.1002/cne.20709","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.20709","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045731954","display_name":"Adam W. Hantman","orcid":"https://orcid.org/0000-0002-6563-1423","observed_orcids":["https://orcid.org/0000-0002-6563-1423"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam W. Hantman","raw_affiliation_strings":["Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112326872","display_name":"Edward R. Perl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward R. Perl","raw_affiliation_strings":["Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112326872"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.9452,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.7365408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"492","issue":"1","first_page":"90","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06800000369548798,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.6230000257492065},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.703000009059906},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"green fluorescent protein","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.753000020980835},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/descending-control","display_name":"descending control","score":0.6290000081062317},{"id":"https://openalex.org/keywords/primary-afferent-neurons","display_name":"primary afferent neurons","score":0.7770000100135803},{"id":"https://openalex.org/keywords/homophilic-interactions","display_name":"homophilic interactions","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neuronal-labeling","display_name":"neuronal labeling","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8219589591026306},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.6627606153488159},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6337131261825562},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5941408276557922},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.4961622655391693},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4473256766796112},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4388889968395233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21773213148117065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19808781147003174},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18300455808639526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08161553740501404}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013376","descriptor_name":"Substantia Gelatinosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013376","descriptor_name":"Substantia Gelatinosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054623","descriptor_name":"Receptor-Like Protein Tyrosine Phosphatases, Class 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064026","descriptor_name":"Calbindins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064030","descriptor_name":"S100 Calcium Binding Protein G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.20709","doi":"https://doi.org/10.1002/cne.20709","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.20709","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:16175558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16175558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1406622440","display_name":null,"funder_award_id":"NS-10321","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4985321511","display_name":null,"funder_award_id":"NS046167","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7285878692","display_name":"PROPERTIES OF LABELED SUBSTANTIA GELATINOSA NEURONS","funder_award_id":"F31NS046167","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1514015858","https://openalex.org/W1530030261","https://openalex.org/W1824892726","https://openalex.org/W1831769215","https://openalex.org/W1853885983","https://openalex.org/W1977742625","https://openalex.org/W1990832845","https://openalex.org/W1997304990","https://openalex.org/W1998490733","https://openalex.org/W2003469582","https://openalex.org/W2004558157","https://openalex.org/W2006933699","https://openalex.org/W2009581026","https://openalex.org/W2011468607","https://openalex.org/W2015413146","https://openalex.org/W2017400430","https://openalex.org/W2020526396","https://openalex.org/W2030573522","https://openalex.org/W2030907144","https://openalex.org/W2031811175","https://openalex.org/W2032983748","https://openalex.org/W2033449042","https://openalex.org/W2035912798","https://openalex.org/W2036793236","https://openalex.org/W2038152105","https://openalex.org/W2038172808","https://openalex.org/W2042847772","https://openalex.org/W2050194934","https://openalex.org/W2050980301","https://openalex.org/W2052869461","https://openalex.org/W2055723831","https://openalex.org/W2059610821","https://openalex.org/W2062371771","https://openalex.org/W2062700118","https://openalex.org/W2065366870","https://openalex.org/W2068860530","https://openalex.org/W2069802098","https://openalex.org/W2082389500","https://openalex.org/W2084083432","https://openalex.org/W2085052553","https://openalex.org/W2086006585","https://openalex.org/W2089202291","https://openalex.org/W2093368672","https://openalex.org/W2107057154","https://openalex.org/W2115568736","https://openalex.org/W2116044769","https://openalex.org/W2117414432","https://openalex.org/W2122997968","https://openalex.org/W2126658684","https://openalex.org/W2126764967","https://openalex.org/W2150456208","https://openalex.org/W2153292899","https://openalex.org/W2159021380","https://openalex.org/W2165079882","https://openalex.org/W2170579633","https://openalex.org/W2305369714","https://openalex.org/W2466119156","https://openalex.org/W4249202898"],"related_works":["https://openalex.org/W2049018428","https://openalex.org/W2143480737","https://openalex.org/W2922335342","https://openalex.org/W1996183380","https://openalex.org/W7057012687","https://openalex.org/W2161721403","https://openalex.org/W3151346585","https://openalex.org/W2062986636","https://openalex.org/W2044999347","https://openalex.org/W2058315531"],"abstract_inverted_index":{"Genetic":[0],"incorporation":[1],"in":[2,30,91,112],"a":[3,6,21],"mouse":[4],"of":[5,23,59,73,86,127,132,137],"transgene":[7,88],"containing":[8],"the":[9,13,38,41,57,84,87,92,100,122],"prion":[10],"promoter":[11],"and":[12,33,52,63,77,99,118,140],"green":[14],"fluorescent":[15],"protein":[16,48,64,94,105],"(GFP)":[17],"coding":[18],"sequence":[19],"labels":[20],"set":[22],"substantia":[24],"gelatinosa":[25],"(SG)":[26],"neurons":[27,43,68,120],"(SG-GFP)":[28],"homogenous":[29],"morphology,":[31],"electrophysiology,":[32],"gamma-amino-butyric":[34],"acid":[35],"expression.":[36],"In":[37],"present":[39],"analysis":[40],"SG-GFP":[42],"are":[44],"established":[45,83],"to":[46,53,89,130],"have":[47],"kinase":[49,65],"C-betaII":[50],"immunoreactivity":[51],"lack":[54],"evidence":[55],"for":[56],"presence":[58],"calbindin":[60],"D-28k,":[61],"parvalbumin,":[62],"C-gamma.":[66],"These":[67],"were":[69],"hyperpolarized":[70],"by":[71],"mediators":[72],"descending":[74],"control,":[75],"norepinephrine":[76],"serotonin.":[78],"Sequential":[79],"polymerase":[80],"chain":[81],"reactions":[82],"insertion":[85],"be":[90],"receptor":[93,102],"tyrosine":[95],"phosphatase":[96],"kappa":[97],"(RPTP-kappa)":[98],"laminin":[101],"1":[103,108],"(ribosomal":[104],"SA)":[106],"pseudogene":[107],"locus.":[109],"RPTP-kappa":[110,128],"expression":[111],"both":[113],"GFP-labeled":[114],"dorsal":[115],"root":[116],"ganglia":[117],"SG":[119,141],"raises":[121],"possibility":[123],"that":[124],"homophilic":[125],"interactions":[126],"contribute":[129],"establishment":[131],"connections":[133],"between":[134],"specific":[135],"classes":[136],"primary":[138],"afferent":[139],"neurons.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}