{"id":"https://openalex.org/W1970117845","doi":"https://doi.org/10.1001/archinte.165.11.1222","title":"Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?","display_name":"Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?","publication_year":2005,"publication_date":"2005-06-13","ids":{"openalex":"https://openalex.org/W1970117845","doi":"https://doi.org/10.1001/archinte.165.11.1222","mag":"1970117845","pmid":"https://pubmed.ncbi.nlm.nih.gov/15956000"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.165.11.1222","doi":"https://doi.org/10.1001/archinte.165.11.1222","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.165.11.1222","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012313888","display_name":"Wei Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Hong Wang","raw_affiliation_strings":["Department of Gastroenterology, Peking University First Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Peking University First Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091235672","display_name":"Jia Huang","orcid":"https://orcid.org/0000-0002-0976-9882","observed_orcids":["https://orcid.org/0000-0002-0976-9882","https://orcid.org/0000-0002-0365-9164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Qing Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022518863","display_name":"Ge Fan Zheng","orcid":"https://orcid.org/0009-0002-3568-6375","observed_orcids":["https://orcid.org/0009-0002-3568-6375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ge Fan Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111563452","display_name":"Wai Man Wong","orcid":"https://orcid.org/0000-0002-3808-3564","observed_orcids":["https://orcid.org/0000-0002-3808-3564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wai Man Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058158458","display_name":"Shiu Kum Lam","orcid":"https://orcid.org/0000-0002-5396-989X","observed_orcids":["https://orcid.org/0000-0002-5396-989X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiu Kum Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113580990","display_name":"JOHAN P. E. KARLBERG","orcid":"https://orcid.org/0009-0006-2535-1239","observed_orcids":["https://orcid.org/0009-0006-2535-1239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan Karlberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052819986","display_name":"Harry Hua\u2010Xiang Xia","orcid":"https://orcid.org/0000-0002-7952-9200","observed_orcids":["https://orcid.org/0000-0002-7952-9200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry H. X. Xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022335823","display_name":"Ronnie Fass","orcid":"https://orcid.org/0000-0002-4807-3052","observed_orcids":["https://orcid.org/0000-0002-4807-3052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronnie Fass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113803995","display_name":"Benjamin CY Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin C. Y. Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.8955,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.98581606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"165","issue":"11","first_page":"1222","last_page":"1222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-cardiac-chest-pain","display_name":"non-cardiac chest pain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/24-hour-ph-monitoring","display_name":"24-hour pH monitoring","score":0.8420000076293945},{"id":"https://openalex.org/keywords/endoscopy","display_name":"endoscopy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/primary-care-diagnosis","display_name":"primary care diagnosis","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8918827772140503},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.7871747016906738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7241578102111816},{"id":"https://openalex.org/C157481446","wikidata":"https://www.wikidata.org/wiki/Q5270351","display_name":"Diagnostic odds ratio","level":3,"score":0.6378870606422424},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6127200126647949},{"id":"https://openalex.org/C2778704086","wikidata":"https://www.wikidata.org/wiki/Q693058","display_name":"Chest pain","level":2,"score":0.6098622679710388},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6095972657203674},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.5846378207206726},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5680051445960999},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5625489950180054},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.518865704536438},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4583089351654053},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42575469613075256},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4009131193161011},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3637349605560303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12169840931892395},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002637","descriptor_name":"Chest Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003938","descriptor_name":"Diagnostic Techniques, Digestive System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1001/archinte.165.11.1222","doi":"https://doi.org/10.1001/archinte.165.11.1222","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.165.11.1222","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:15956000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15956000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/162859","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/162859","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2189171839","doi":null,"is_oa":false,"landing_page_url":"http://lib.ajaums.ac.ir/booklist/archives%20of%20neurology_June-11_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2287715821","doi":null,"is_oa":false,"landing_page_url":"https://hub.hku.hk/handle/10722/95773","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W85457832","https://openalex.org/W150135378","https://openalex.org/W189205520","https://openalex.org/W1485977227","https://openalex.org/W1577289778","https://openalex.org/W1964064196","https://openalex.org/W1968409528","https://openalex.org/W1974147433","https://openalex.org/W1977031410","https://openalex.org/W1977311284","https://openalex.org/W1982936434","https://openalex.org/W1994490818","https://openalex.org/W1994841204","https://openalex.org/W1997797587","https://openalex.org/W2008373894","https://openalex.org/W2009955222","https://openalex.org/W2016260325","https://openalex.org/W2017423145","https://openalex.org/W2017578760","https://openalex.org/W2029990428","https://openalex.org/W2045063605","https://openalex.org/W2055778846","https://openalex.org/W2057631921","https://openalex.org/W2058396425","https://openalex.org/W2058412787","https://openalex.org/W2059146824","https://openalex.org/W2061065284","https://openalex.org/W2070289225","https://openalex.org/W2071802332","https://openalex.org/W2073426135","https://openalex.org/W2077429617","https://openalex.org/W2083205682","https://openalex.org/W2088323328","https://openalex.org/W2088761266","https://openalex.org/W2089252019","https://openalex.org/W2107328434","https://openalex.org/W2113009004","https://openalex.org/W2122152919","https://openalex.org/W2139129657","https://openalex.org/W2150617429","https://openalex.org/W2157389358","https://openalex.org/W2321875167","https://openalex.org/W2341741338","https://openalex.org/W2921514360","https://openalex.org/W3208146045"],"related_works":["https://openalex.org/W4220912707","https://openalex.org/W3094132331","https://openalex.org/W3211148752","https://openalex.org/W2043399185","https://openalex.org/W2066299736","https://openalex.org/W2978098645","https://openalex.org/W2038825596","https://openalex.org/W2771774165","https://openalex.org/W2090447596","https://openalex.org/W2010002954"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastroesophageal":[1],"reflux":[2],"disease":[3],"(GERD)":[4],"is":[5],"common":[6],"in":[7,71,76,160,190,237,262],"patients":[8,77,238,264],"with":[9,78,149,173,185,239,265],"noncardiac":[10],"chest":[11],"pain":[12],"(NCCP).":[13],"Results":[14],"of":[15,20,41,66,74,87,131,179,196,199,207,215,218,222,227],"studies":[16,62,121],"evaluating":[17,63],"the":[18,38,47,64,72,110,123,161,191,197,205,208,216],"accuracy":[19,40,65,112,206],"a":[21,28,132,168,174,231],"proton":[22],"pump":[23],"inhibitor":[24],"(PPI)":[25],"treatment":[26,202,229],"as":[27,230,251],"diagnostic":[29,96,176,232],"test":[30,134,166,209,233],"for":[31,234],"GERD-related":[32],"NCCP":[33,240],"have":[34],"varied.":[35],"We":[36,45],"evaluated":[37],"overall":[39,111,127],"this":[42],"modality.":[43],"METHODS:":[44],"searched":[46],"PubMed,":[48],"MEDLINE,":[49],"EMBASE,":[50],"CINAHL,":[51],"and":[52,58,99,113,129,142,154,201,245,247],"Cochrane":[53],"databases":[54],"to":[55,108,114,259],"May":[56],"2004":[57],"included":[59],"randomized,":[60],"placebo-controlled":[61],"findings":[67],"from":[68],"PPI":[69,133,165,228],"testing":[70],"diagnosis":[73,82],"GERD":[75,81,200,236,261],"NCCP.":[79,266],"The":[80,126,164,194,225],"was":[83],"confirmed":[84],"by":[85,255],"results":[86],"endoscopy":[88],"and/or":[89],"24-hour":[90],"esophageal":[91],"pH":[92],"monitoring.":[93],"A":[94],"summary":[95,100,175],"odds":[97,177],"ratio":[98,178],"receiver":[101],"operating":[102],"characteristic":[103],"curve":[104],"analysis":[105],"were":[106,135],"used":[107,250],"estimate":[109],"explore":[115],"any":[116],"contributing":[117],"factors.":[118],"RESULTS:":[119],"Six":[120],"met":[122],"inclusion":[124],"criteria.":[125],"sensitivity":[128,244],"specificity":[130,246],"80%":[136],"(95%":[137,144,151,156,181,187],"confidence":[138],"interval":[139],"[CI],":[140],"71%-87%)":[141],"74%":[143],"CI,":[145,152,157,182,188],"64%-83%),":[146],"respectively,":[147,159],"compared":[148,184],"19%":[150],"12%-29%)":[153],"77%":[155],"62%-87%),":[158],"placebo":[162,192],"group.":[163,193],"showed":[167],"significant":[169],"higher":[170],"discriminative":[171],"power,":[172],"19.35":[180],"8.54-43.84)":[183],"0.61":[186],"0.20-1.86)":[189],"impact":[195],"prevalence":[198],"duration":[203],"on":[204],"could":[210,248],"not":[211],"be":[212,249],"determined":[213],"because":[214],"lack":[217],"an":[219,242,252],"adequate":[220],"number":[221],"studies.":[223],"CONCLUSION:":[224],"use":[226],"detecting":[235],"has":[241],"acceptable":[243],"initial":[253],"approach":[254],"primary":[256],"care":[257],"physicians":[258],"detect":[260],"selected":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
