{"id":"https://openalex.org/W1970069201","doi":"https://doi.org/10.1159/000238074","title":"Penetration of Alafosfalin and Ampicillin into Tissue Cage Fluid in Rabbits","display_name":"Penetration of Alafosfalin and Ampicillin into Tissue Cage Fluid in Rabbits","publication_year":2009,"publication_date":"2009-09-08","ids":{"openalex":"https://openalex.org/W1970069201","doi":"https://doi.org/10.1159/000238074","mag":"1970069201","pmid":"https://pubmed.ncbi.nlm.nih.gov/7094659"},"language":"en","primary_location":{"id":"doi:10.1159/000238074","doi":"https://doi.org/10.1159/000238074","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000238074","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111795094","display_name":"Claes Henning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125766","display_name":"L\u00e4nssjukhuset Sundsvall-H\u00e4rn\u00f6sand","ror":"https://ror.org/02z9b2w17","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210125766"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Claes Henning","raw_affiliation_strings":["Department of Clinical Bacteriology, Sundsvall Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Bacteriology, Sundsvall Hospital, Sweden","institution_ids":["https://openalex.org/I4210125766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045550662","display_name":"Otto Cars","orcid":"https://orcid.org/0000-0003-4220-8136","observed_orcids":["https://orcid.org/0000-0003-4220-8136"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Otto Cars","raw_affiliation_strings":["Departments of Clinical Bacteriology and Infectious Diseases, University of Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Bacteriology and Infectious Diseases, University of Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.13231295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"3","first_page":"185","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.6380000114440918},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.6679999828338623},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.8624393939971924},{"id":"https://openalex.org/C2908754555","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Tissue fluid","level":2,"score":0.683030366897583},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.622327983379364},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.5434740781784058},{"id":"https://openalex.org/C2777300098","wikidata":"https://www.wikidata.org/wiki/Q1164665","display_name":"Subcutaneous tissue","level":2,"score":0.4208880364894867},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3955310881137848},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3579113483428955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3073716163635254},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.287143349647522},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22545108199119568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18559640645980835},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000238074","doi":"https://doi.org/10.1159/000238074","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000238074","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:7094659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7094659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051726859","https://openalex.org/W2323289181","https://openalex.org/W2086279163","https://openalex.org/W1986235555","https://openalex.org/W1998218956","https://openalex.org/W2018357666","https://openalex.org/W2076336879","https://openalex.org/W2517502179","https://openalex.org/W2067538881","https://openalex.org/W2424080365"],"abstract_inverted_index":{"The":[0,25],"pharmacokinetics":[1],"of":[2,27,31],"alafosfalin":[3,28],"and":[4,33,43],"ampicillin":[5,32],"were":[6,12,36],"studied":[7],"in":[8,16],"rabbits.":[9],"Serum":[10],"concentrations":[11,26],"compared":[13],"to":[14],"levels":[15],"subcutaneous":[17],"tissue":[18,23,44],"fluid":[19],"obtained":[20],"from":[21,41],"implanted":[22],"cages.":[24],"exceeded":[29],"those":[30],"the":[34],"drugs":[35],"eliminated":[37],"at":[38],"similar":[39],"rates":[40],"serum":[42],"fluid.":[45]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
