{"id":"https://openalex.org/W19700527","doi":null,"title":"Valve surgery for infective endocarditis is associated with high hospital charges.","display_name":"Valve surgery for infective endocarditis is associated with high hospital charges.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W19700527","mag":"19700527","pmid":"https://pubmed.ncbi.nlm.nih.gov/23610998"},"language":"en","primary_location":{"id":"pmid:23610998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23610998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032450814","display_name":"Clinton D. Kemp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clinton D Kemp","raw_affiliation_strings":["Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032805026","display_name":"George J. Arnaoutakis","orcid":"https://orcid.org/0000-0002-7648-0747","observed_orcids":["https://orcid.org/0000-0002-7648-0747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George J Arnaoutakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091432448","display_name":"Timothy J. George","orcid":"https://orcid.org/0000-0003-0953-0895","observed_orcids":["https://orcid.org/0000-0003-0953-0895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J George","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Maurice A Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurice A Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614274","display_name":"Nishant D. Patel","orcid":"https://orcid.org/0000-0002-2573-7469","observed_orcids":["https://orcid.org/0000-0002-2573-7469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nishant D Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011840616","display_name":"Duke Edward Cameron","orcid":"https://orcid.org/0000-0001-7193-1329","observed_orcids":["https://orcid.org/0000-0001-7193-1329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duke E Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078708353","display_name":"Ashish S. Shah","orcid":"https://orcid.org/0000-0002-3375-7865","observed_orcids":["https://orcid.org/0000-0002-3375-7865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish S Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2138,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78721156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"110","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.996999979019165},{"id":"https://openalex.org/keywords/valve-surgery","display_name":"valve surgery","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hospital-charges","display_name":"hospital charges","score":0.671999990940094},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.7120000123977661},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8640000224113464},{"id":"https://openalex.org/keywords/emergency-surgery","display_name":"emergency surgery","score":0.6840000152587891},{"id":"https://openalex.org/keywords/preoperative-renal-failure","display_name":"preoperative renal failure","score":0.8600000143051147},{"id":"https://openalex.org/keywords/people-who-inject-drugs","display_name":"people who inject drugs","score":0.796999990940094},{"id":"https://openalex.org/keywords/aortic-valve-endocarditis","display_name":"aortic valve endocarditis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitral-valve-endocarditis","display_name":"mitral valve endocarditis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/postoperative-gastrointestinal-complications","display_name":"postoperative gastrointestinal complications","score":0.7580000162124634},{"id":"https://openalex.org/keywords/atrioventricular-block","display_name":"atrioventricular block","score":0.7160000205039978},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.8040000200271606},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.986846387386322},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8115516901016235},{"id":"https://openalex.org/C2780176578","wikidata":"https://www.wikidata.org/wiki/Q2450598","display_name":"Infective endocarditis","level":2,"score":0.6759524345397949},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.500091552734375},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4966133236885071},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.47340402007102966},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.4697100520133972},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4672068953514099},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.4175518751144409},{"id":"https://openalex.org/C2776570981","wikidata":"https://www.wikidata.org/wiki/Q4413093","display_name":"Aortic valve replacement","level":3,"score":0.4157223403453827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3739140033721924},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3350820541381836},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.08919113874435425}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004696","descriptor_name":"Endocarditis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D004696","descriptor_name":"Endocarditis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006351","descriptor_name":"Heart Valves","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008396","descriptor_name":"Maryland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017722","descriptor_name":"Hospital Charges","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D019918","descriptor_name":"Heart Valve Prosthesis Implantation","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23610998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23610998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},{"id":"mag:19700527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23610998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045993067","https://openalex.org/W4405783053","https://openalex.org/W1992980703","https://openalex.org/W2766543504","https://openalex.org/W2308056572","https://openalex.org/W2104322847","https://openalex.org/W4288515310","https://openalex.org/W4200584461","https://openalex.org/W2994157146","https://openalex.org/W4229336445"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"STUDY:":[5],"Half":[6],"of":[7,34,41,98,104,193,377],"all":[8],"patients":[9,50,106,140,168,207,261,311,335],"with":[10,189,213,269,278,319,336,363,380,385,401],"infective":[11],"endocarditis":[12],"(IE)":[13],"will":[14,22],"require":[15],"early":[16],"surgical":[17,25,32],"intervention,":[18],"and":[19,76,94,130,150,156,161,170,202,238,260,310,338,351,388,405],"another":[20],"40%":[21],"eventually":[23],"undergo":[24],"treatment":[26],"for":[27,55,119,206,347,356,359],"their":[28],"disease.":[29],"Although":[30],"the":[31,38,42,60,95,331,339,369],"management":[33],"IE":[35,58,163,215,360],"is":[36],"effective,":[37],"financial":[39,366],"impact":[40],"disease":[43],"has":[44],"never":[45],"been":[46],"assessed.":[47],"METHODS:":[48],"All":[49],"who":[51,390,395],"underwent":[52,117,391],"valve":[53,57,158],"surgery":[54,118,355],"native":[56],"at":[59],"present":[61,327],"authors'":[62],"institution":[63],"over":[64],"a":[65,190,364,373,402],"10-year":[66],"period":[67],"(1996-2006)":[68],"were":[69,74,133,181,204,288,345,399],"reviewed":[70],"retrospectively.":[71],"Hospital":[72],"charges":[73,93,180,201,350],"identified":[75,165],"adjusted":[77],"to":[78,89,275,333,368],"reflect":[79],"US$":[80,182,187],"in":[81,166,341],"2006.":[82],"A":[83,102],"logistic":[84],"regression":[85],"analysis":[86],"was":[87,164,222,329],"performed":[88],"identify":[90],"factors":[91,344],"affecting":[92],"patients'":[96],"length":[97],"stay":[99],"(LOS).":[100],"RESULTS:":[101],"total":[103],"369":[105],"(252":[107],"males,":[108],"117":[109],"females;":[110],"mean":[111],"age":[112],"53":[113],"+/-":[114],"15":[115,194],"years)":[116],"IE.":[120,159,176],"Of":[121],"these":[122],"patients,":[123],"121":[124],"(33%)":[125],"had":[126,142,147,153,173,396],"preoperative":[127,227,382],"renal":[128,228,245],"failure":[129,229,246],"70":[131],"(20%)":[132],"intravenous":[134],"drug":[135],"users.":[136],"In":[137],"addition,":[138],"159":[139],"(43%)":[141],"aortic":[143,155],"IE,":[144,149,337,398],"112":[145],"(30%)":[146],"mitral":[148,157],"45":[151],"(12%)":[152],"both":[154],"Right-":[160],"left-sided":[162],"42":[167],"(11%),":[169],"11":[171],"(3%)":[172],"isolated":[174],"right-sided":[175],"The":[177,219,326],"median":[178,191],"hospital":[179,200,281,349,407],"60,072":[183],"(interquartile":[184],"range":[185],"(IQR)":[186],"39,386-103,960),":[188],"LOS":[192,203,287,404],"days":[195],"(IQR":[196],"9-29":[197],"days).":[198],"Both,":[199],"higher":[205],"undergoing":[208,262,312],"emergent":[209,263,313,392],"operations,":[210],"or":[211,268,318,394],"those":[212,384,389],"active":[214,270,320,397],"(p":[216,230,235,242,247,252,257,265,272,292,298,302,307,315,322],"<":[217,243,253,258,266,273,308,316,323],"0.001).":[218,324],"30-day":[220],"mortality":[221,256],"2.7%.":[223],"Regression":[224],"analyses":[225],"showed":[226],"=":[231,236,248,293,299,303],"0.007),":[232],"intraoperative":[233],"transfusion":[234],"0.028)":[237],"postoperative":[239,295,386],"gastrointestinal":[240,296],"complications":[241,297],"0.001),":[244,254,259,267,300,309],"0.012),":[249],"heart":[250,305],"block":[251,306],"in-hospital":[255],"procedures":[264,314,393],"infection":[271,321],"0.001)":[274,317],"be":[276],"associated":[277,362,400],"significantly":[279,285],"increased":[280,348,406],"charges.":[282,408],"Factors":[283],"that":[284],"affected":[286],"other":[289],"non-white":[290],"race":[291],"0.039),":[294],"stroke":[301],"0.014),":[304],"CONCLUSION:":[325],"series":[328],"among":[330],"largest":[332],"include":[334],"first":[340],"which":[342],"risk":[343],"assessed":[346],"resource":[352],"utilization":[353],"following":[354],"endocarditis.":[357],"Operations":[358],"are":[361],"significant":[365,381],"burden":[367],"healthcare":[370],"system,":[371],"despite":[372],"relatively":[374],"low":[375],"percentage":[376],"complications.":[378],"Patients":[379],"comorbidities,":[383],"complications,":[387],"prolonged":[403]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}