{"id":"https://openalex.org/W1970052005","doi":"https://doi.org/10.1111/bjd.13692","title":"Ponatinib\u2010induced pityriasiform, folliculocentric and ichthyosiform cutaneous toxicities","display_name":"Ponatinib\u2010induced pityriasiform, folliculocentric and ichthyosiform cutaneous toxicities","publication_year":2015,"publication_date":"2015-03-04","ids":{"openalex":"https://openalex.org/W1970052005","doi":"https://doi.org/10.1111/bjd.13692","mag":"1970052005","pmid":"https://pubmed.ncbi.nlm.nih.gov/25736577"},"language":"en","primary_location":{"id":"doi:10.1111/bjd.13692","doi":"https://doi.org/10.1111/bjd.13692","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.13692","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037964970","display_name":"Allireza Alloo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Alloo","raw_affiliation_strings":["Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","Department of Dermatology Brigham and Women's Hospital Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Dermatology Brigham and Women's Hospital Boston MA U.S.A","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045534836","display_name":"Johanna Sheu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Sheu","raw_affiliation_strings":["Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087253387","display_name":"James Edward Butrynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.E. Butrynski","raw_affiliation_strings":["Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082924494","display_name":"Daniel J. DeAngelo","orcid":"https://orcid.org/0000-0001-7865-2306","observed_orcids":["https://orcid.org/0000-0001-7865-2306"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.J. DeAngelo","raw_affiliation_strings":["Centre for Hematological Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Hematological Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078289621","display_name":"Suzanne George","orcid":"https://orcid.org/0000-0002-1284-8493","observed_orcids":["https://orcid.org/0000-0002-1284-8493","https://orcid.org/0000-0002-8777-8530"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. George","raw_affiliation_strings":["Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Sarcoma and Bone Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018856906","display_name":"G\u00eborge F. Murphy","orcid":"https://orcid.org/0000-0001-9362-5146","observed_orcids":["https://orcid.org/0000-0001-9362-5146"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.F. Murphy","raw_affiliation_strings":["Department of Pathology Brigham and Women's Hospital Boston MA U.S.A","Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Brigham and Women's Hospital Boston MA U.S.A","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078193406","display_name":"Nicole R. LeBoeuf","orcid":"https://orcid.org/0000-0002-8264-834X","observed_orcids":["https://orcid.org/0000-0002-8264-834X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N.R. LeBoeuf","raw_affiliation_strings":["Centre for Cutaneous Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","Department of Dermatology Brigham and Women's Hospital Boston MA U.S.A","Harvard Medical School Boston MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cutaneous Oncology Dana Farber Cancer Institute 375 Longwood Avenue Boston MA 02115 U.S.A","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Dermatology Brigham and Women's Hospital Boston MA U.S.A","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School Boston MA U.S.A","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078193406"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":4.8337,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.95045437,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"173","issue":"2","first_page":"574","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/drug-induced-skin-reaction","display_name":"drug-induced skin reaction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hyperkeratosis","display_name":"hyperkeratosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-toxicity","display_name":"tyrosine kinase inhibitor toxicity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/orthokeratosis","display_name":"orthokeratosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/drug-induced-skin-eruption","display_name":"drug-induced skin eruption","score":0.375},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2776292323","wikidata":"https://www.wikidata.org/wiki/Q523893","display_name":"Ichthyosis","level":2,"score":0.6492974162101746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6196612119674683},{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.5556829571723938},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5042470693588257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2398800253868103},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005499","descriptor_name":"Folliculitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007057","descriptor_name":"Ichthyosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010915","descriptor_name":"Pityriasis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjd.13692","doi":"https://doi.org/10.1111/bjd.13692","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.13692","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:25736577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25736577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320309021","display_name":"Ariad Pharmaceuticals","ror":"https://ror.org/01dwtyk53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1966530290","https://openalex.org/W1986888912","https://openalex.org/W1994309500","https://openalex.org/W2011474502","https://openalex.org/W2025493301","https://openalex.org/W2054251966","https://openalex.org/W2066099870","https://openalex.org/W2080125373","https://openalex.org/W2104694028","https://openalex.org/W2141463412","https://openalex.org/W2147109509","https://openalex.org/W2171722798"],"related_works":["https://openalex.org/W4388191364","https://openalex.org/W4310920925","https://openalex.org/W4402813218","https://openalex.org/W2768342438","https://openalex.org/W7166158178","https://openalex.org/W4313506103","https://openalex.org/W2807794132","https://openalex.org/W2259821246","https://openalex.org/W4406184503","https://openalex.org/W2768371270"],"abstract_inverted_index":{"Dear":[0],"Editor,":[1],"Ponatinib,":[2],"a":[3,43,72,204,212,252,382,619,655,693,1009,1061],"potent":[4],"third\u2010generation":[5,1010],"tyrosine":[6],"kinase":[7],"inhibitor":[8],"(TKI),":[9],"has":[10,850,1069,1248,1272,1281],"demonstrated":[11,325,829],"significant":[12,351,688,1028,1141],"efficacy":[13],"in":[14,31,136,159,240,335,498,511,668,687,769,784,802,840,854,912,1035,1052,1113,1224],"chronic":[15],"myelogenous":[16],"leukaemia":[17,24],"(CML)":[18],"and":[19,26,66,89,99,123,139,183,211,221,246,270,273,314,331,343,398,401,411,431,436,439,456,467,480,493,495,502,514,518,525,535,543,554,588,594,611,639,662,717,722,731,733,817,825,857,864,882,900,904,928,959,978,987,991,995,1018,1023,1031,1055,1086,1102,1119,1143,1173,1193,1221,1233,1245,1287,1294],"Philadelphia":[20],"chromosome\u2010positive":[21],"acute":[22],"lymphocytic":[23,657],"(ALL),":[25],"is":[27,71,251,381,618,692],"currently":[28],"being":[29],"employed":[30],"solid":[32,855],"organ":[33],"tumour":[34,80,856],"trials.":[35],"Among":[36],"the":[37,150,160,175,188,199,231,234,266,279,310,366,396,484,491,522,532,546,559,582,637,672,676,738,917,924,938,971,974,1090,1124,1127,1156,1194,1216,1229,1252],"most":[38,939],"common":[39,940,1192],"side\u2010effects":[40],"reported":[41,932,1001,1158],"are":[42,998,1191],"nonspecific":[44,933,985],"rash":[45],"or":[46,935,1152],"dry":[47],"skin.1":[48],"2":[49,101,250,744,1056,1058],"We":[50],"report":[51,1064],"five":[52],"patients":[53],"treated":[54,114,295,680,810],"with":[55,75,84,91,115,119,144,163,255,260,276,296,300,312,329,373,376,385,390,404,461,622,627,631,659,681,696,701,708,787,811,820,831,861,1002,1043,1140,1163,1170,1185],"ponatinib":[56,106,134,286,418,509,646,749,758,1026,1101,1153,1220],"who":[57],"developed":[58,1014],"prominent":[59,449,555,632,1083],"pityriasis":[60,127],"rubra":[61,128],"pilaris":[62,129],"(PRP)\u2010like,":[63],"hyperkeratotic,":[64],"folliculocentric":[65,656],"ichthyosiform":[67,206,1087,1234],"eruptions.":[68],"Case":[69,249,379,616,690],"1":[70,138,1054],"59\u2010year\u2010old":[73],"man":[74,384,621],"refractory":[76,1178],"metastatic":[77,386,623,697],"gastrointestinal":[78],"stromal":[79],"(GIST).":[81],"He":[82,112,388,424,476,625],"presented":[83,259,389,626,700],"asymptomatic,":[85,261],"red\u2013orange,":[86],"follicular\u2010based":[87,393],"papules":[88,394],"plaques":[90,143,158,173,264,275,707],"bran\u2010like,":[92,145],"powdery":[93,146],"white":[94,147],"scale":[95,148,277,435,443,732],"over":[96,149,407,636],"his":[97,408,448],"thighs":[98,153,191],"axillae,":[100],"weeks":[102,282,745],"following":[103,415,643,746],"initiation":[104,135,284,416,510,644,747],"of":[105,126,165,196,233,285,309,353,358,417,464,471,473,505,531,545,579,605,645,675,710,748,756,772,805,835,845,867,886,891,926,965,973,1065,1093,1108,1126,1196,1208,1219,1228,1231,1241,1263,1269],"45":[107,287,419,647,750,795],"mg":[108,288,420,648,751,781,796],"daily":[109,289,421,649,782,797],"(Fig.":[110,290,321,337,422,429,650,665],"1a,b).":[111],"was":[113,370,454,679,759,809,916,1013],"topical":[116,344,359,374,486,818,836,1167,1171],"triamcinolone":[117],"cream":[118,299,489,838],"near\u2010complete":[120,841],"resolution.":[121,378,842],"Clinical":[122,501],"histopathological":[124,503],"figures":[125],"(PRP)\u2010like":[130],"skin":[131,197,506,580],"changes":[132,507,958],"after":[133,283,508],"cases":[137,512],"2.":[140],"(a)":[141,516],"Pink\u2013orange":[142,157],"bilateral":[151,714,723],"posterior":[152,718],"(case":[154,167,179,192,218,243,538,549,561,575,591,608],"1).":[155,168],"(b)":[156,540],"left":[161,200,547],"axillae":[162,269],"islands":[164,709],"sparing":[166,527,711],"(c)":[169,551],"Pink\u2013orange,":[170],"scaly,":[171],"thin":[172,263,274],"on":[174,187,265,278,317,365,395,444,521,558,712,737,1199,1274,1283],"proximal":[176,267,399],"outer":[177],"arms":[178],"2).":[180,193],"(d)":[181,563],"Ichthyosiform":[182],"plate\u2010like":[184,315],"asteatotic":[185],"patches":[186,316,736],"lateral":[189,271,426,739],"upper":[190,201,720,724],"(e)":[194,577],"Biopsy":[195,578],"from":[198,581,872,1291],"arm":[202],"shows":[203,585],"compacted":[205],"orthokeratosis,":[207],"mild":[208,465],"diffuse":[209,432],"spongiosis":[210],"scant":[213],"superficial":[214,458],"perivascular":[215],"lymphoid":[216],"infiltrate":[217,658],"2)":[219,244],"(haematoxylin":[220,245,593,610],"eosin,":[222,247,595,612],"10\u00d7).":[223,596],"(f)":[224,597],"Higher":[225,598],"magnification":[226,599],"demonstrates":[227,600,1027],"subtle":[228],"alteration":[229],"to":[230,362,762,793,852,897,909,968,1254],"density":[232],"orthokeratin,":[235],"as":[236,333,667,937,1080,1082,1187,1237],"can":[237],"be":[238,1183],"seen":[239,334],"PRP\u2010like":[241,367,960,1067,1078],"reactions":[242],"20\u00d7).":[248,613],"79\u2010year\u2010old":[253],"woman":[254,695],"treatment\u2010refractory":[256],"CML.":[257],"She":[258,292,348,699,726,808],"pink\u2013orange,":[262],"arms,":[268],"breasts,":[272],"scalp,":[280,485,816],"4":[281,617,943],"1c).":[291],"had":[293,440,728],"been":[294,1070],"hydrocortisone":[297],"2\u00b75%":[298],"minimal":[301],"improvement.":[302,500,689],"Additionally,":[303],"she":[304,369,828],"described":[305],"new\u2010onset":[306],"\u2018dry":[307],"skin\u2019":[308],"trunk,":[311,494],"xerosis":[313,994],"her":[318,354,713,806,815,823],"lower":[319],"extremities":[320],"1d).":[322],"Histological":[323,652],"examination":[324,653],"subacute":[326],"spongiotic":[327],"dermatitis":[328],"orthokeratosis":[330],"parakeratosis":[332],"PRP":[336],"1e,f).":[338],"Liberal":[339],"emollients,":[340,496],"ketoconazole":[341,478,812],"shampoo":[342,479,813],"steroids":[345,360,819,1172],"were":[346,1049],"initiated.":[347],"initially":[349],"experienced":[350],"improvement":[352,830,1142],"symptoms;":[355],"however,":[356],"discontinuation":[357],"led":[361,851,908],"recurrence.":[363],"Based":[364],"morphology,":[368],"subsequently":[371],"managed":[372],"tazarotene,":[375],"complete":[377,770,803,1145],"3":[380,513,754],"65\u2010year\u2010old":[383],"GIST.":[387,624,698,929,1040],"pruritic,":[391,703],"pink,":[392],"trunk":[397,824],"thighs,":[400],"follicular":[402,468,519,556,601,633,663],"prominence":[403,520],"hyperkeratotic":[405,567,634,673],"spicules":[406,568,635],"beard":[409,523],"area":[410,524],"eyebrows,":[412],"10":[413,1006],"days":[414,642],"2a).":[423],"noted":[425],"eyebrow":[427,548],"alopecia":[428,542],"2b)":[430],"scalp":[433,450,729],"erythema,":[434,993],"hair":[437,570,574],"thinning,":[438],"ichthyosis":[441],"vulgaris\u2010like":[442],"both":[445],"legs.":[446],"Given":[447,671,1123],"findings,":[451],"punch":[452],"biopsy":[453],"performed":[455],"revealed":[457,654],"perifollicular":[459,586,629,660],"fibrosis":[460,587,661],"focal":[462],"zones":[463],"acanthosis":[466],"dyskeratosis,":[469],"suggestive":[470],"evidence":[472],"altered":[474,606,1114],"maturation.":[475],"initiated":[477],"clobetasol":[481],"solution":[482],"for":[483,490,798,814,822,878,923,1015,1136,1277,1286],"tretinoin":[487],"0\u00b71%":[488],"face":[492],"resulting":[497,686,1112],"marked":[499],"images":[504],"4.":[515],"Erythema":[517],"neck,":[526,719],"classical":[528],"seborrhoeic":[529,1085],"areas":[530,537],"nasolabial":[533],"fold":[534],"submental":[536,716],"3).":[539,550],"Lateral":[541],"thinning":[544],"Perifollicular":[552],"erythema":[553,630,730],"ostia":[557],"abdomen":[560,584],"4).":[562,576],"Dermoscopy":[564],"demonstrating":[565],"central":[566],"within":[569,774,1202],"follicles,":[571],"surrounding":[572],"each":[573],"right":[583],"overlying":[589],"hyperkeratosis":[590],"4)":[592,609],"dyskeratosis":[602,664],"potentially":[603],"indicative":[604],"maturation":[607],"F,":[614],"follicle.":[615],"72\u2010year\u2010old":[620],"asymptomatic":[628],"chest":[638],"abdomen,":[640],"7":[641,775,963],"2c,d).":[651],"2e,f),":[666],"case":[669,1063,1159],"3.":[670],"nature":[674],"lesions,":[677],"he":[678],"ammonium":[682],"lactate":[683],"12%":[684],"cream,":[685],"5":[691],"62\u2010year\u2010old":[694],"minimally":[702],"orange\u2013red,":[704],"plate\u2010like,":[705,734],"annular":[706],"cheeks,":[715],"back":[721],"arms.":[725],"also":[727,999],"xerotic":[735],"thighs.":[740],"Her":[741],"eruption":[742,785,1068],"began":[743],"daily.":[752],"After":[753],"months":[755],"therapy,":[757],"held":[760],"due":[761],"elevated":[763],"lipase":[764],"levels.":[765],"This":[766],"cessation":[767],"resulted":[768,783,801,839],"resolution":[771,1147],"eruptions":[773,1095,1211],"days.":[776],"Ponatinib":[777],"reinitiation":[778],"at":[779,1021],"30":[780],"recurrence,":[786],"less":[788],"severe":[789],"findings.":[790],"A":[791],"return":[792],"dosing":[794],"disease":[799],"progression":[800],"recurrence":[804],"eruption.":[807],"emollients":[821],"extremities.":[826],"While":[827,1089,1155],"this":[832],"regimen,":[833],"addition":[834],"tazarotene":[837],"The":[843,1239],"emergence":[844],"novel,":[846],"targeted,":[847],"oncological":[848],"therapies":[849,1258],"achievements":[853],"haematological":[858],"malignancy":[859],"management,":[860],"increased":[862],"survival":[863],"improved":[865],"quality":[866,1262],"life.":[868,1264],"However,":[869],"dermatological":[870,981,1046],"toxicities":[871,894,982,1244],"these":[873,892,949,1003,1094,1209,1242],"drugs":[874],"have":[875,907,946],"gained":[876],"notoriety":[877],"their":[879],"visibility,":[880],"frequency":[881],"unfortunate":[883],"resultant":[884],"interruption":[885],"anticancer":[887,1257],"therapy.":[888,914],"Appropriate":[889],"management":[890,1139,1247],"cutaneous":[893,941,1115,1210,1243],"presents":[895],"challenges":[896],"oncologists,":[898],"dermatologists":[899],"patients.":[901],"Targeted":[902],"TKIs":[903,976,1104],"multikinase":[905],"inhibitors":[906],"undeniable":[910],"advances":[911],"cancer":[913],"Imatinib":[915],"first":[918],"commercially":[919],"available":[920],"TKI":[921],"approved":[922],"treatment":[925],"CML":[927,1017],"Initial":[930],"trials":[931],"\u2018rash\u2019":[934],"\u2018dermatitis\u2019":[936],"toxicity;3":[942],"subsequent":[944],"studies":[945],"further":[947],"characterized":[948],"toxicities,":[950],"including":[951,984,1039],"facial":[952],"oedema,":[953],"morbilliform":[954],"eruptions,":[955,989,1079],"xerosis,":[956],"pigmentary":[957],"eruptions.5":[961],"6":[962],"Emergence":[964],"therapeutic":[966,1217],"resistance":[967],"imatinib":[969],"catalysed":[970],"development":[972],"second\u2010generation":[975],"dasatinib":[977],"nilotinib.":[979],"Similar":[980],"\u2013":[983,997],"macular":[986],"papular":[988],"localized":[990],"generalized":[992],"pruritus":[996],"commonly":[1000,1050],"agents.8":[1004],"9":[1005],"11":[1007],"Recently,":[1008],"TKI,":[1011],"ponatinib,":[1012],"treatment\u2010resistant":[1016],"ALL.":[1019],"Aimed":[1020],"wild\u2010type":[1022],"mutant":[1024],"BCR\u2010ABL,":[1025],"antileukaemic":[1029],"activity":[1030],"holds":[1032],"much":[1033],"promise":[1034],"treating":[1036],"other":[1037,1103],"malignancies,":[1038],"Much":[1041],"like":[1042],"its":[1044],"predecessors,":[1045],"adverse":[1047],"events":[1048],"observed":[1051,1076],"phase":[1053],"studies.1":[1057],"To":[1059],"date,":[1060],"single":[1062],"ponatinib\u2010induced":[1066],"published.12":[1071],"In":[1072,1177],"our":[1073,1131,1226],"patients,":[1074],"we":[1075,1098,1165],"similar":[1077],"well":[1081],"folliculocentric,":[1084],"changes.":[1088],"pathogenic":[1091],"mechanism":[1092,1218],"remains":[1096,1205],"undefined,":[1097],"suspect":[1099],"that":[1100],"may":[1105,1212],"cause":[1106],"dysregulation":[1107],"downstream":[1109],"inflammatory":[1110,1232],"pathways":[1111,1201],"regulatory":[1116],"immune":[1117],"surveillance":[1118],"aberrant":[1120],"epidermal":[1121],"growth.":[1122],"similarity":[1125],"nonlife\u2010threatening":[1128],"exanthemas":[1129],"across":[1130],"cohort,":[1132],"early":[1133],"identification":[1134],"allowed":[1135],"effective":[1137],"conservative":[1138],"often":[1144],"symptom":[1146],"without":[1148],"requiring":[1149],"systemic":[1150,1180,1197],"immunosuppressants":[1151],"discontinuation.":[1154],"prior":[1157],"used":[1160],"oral":[1161],"acitretin":[1162],"clearance,12":[1164],"recommend":[1166],"retinoid":[1168],"therapy":[1169],"antiseborrhoeic":[1174],"agents":[1175],"first.":[1176],"cases,":[1179],"retinoids":[1181,1198],"should":[1182],"considered":[1184],"caution,":[1186],"liver":[1188],"enzyme":[1189],"abnormalities":[1190],"effect":[1195],"molecular":[1200],"malignant":[1203],"cells":[1204],"unknown.":[1206],"Classification":[1207],"provide":[1213],"insight":[1214],"into":[1215],"prove":[1222],"critical":[1223],"expanding":[1225],"understanding":[1227],"pathogenesis":[1230],"disorders":[1235],"such":[1236],"PRP.":[1238],"recognition":[1240],"appropriate":[1246],"great":[1249],"implications,":[1250],"specifically":[1251],"ability":[1253],"maintain":[1255],"life\u2010sustaining":[1256],"while":[1259],"improving":[1260],"patient":[1261],"Funding":[1265],"sources:":[1266],"none.":[1267],"Conflicts":[1268],"interest:":[1270],"D.J.D.":[1271],"served":[1273,1282],"advisory":[1275,1284],"boards":[1276,1285],"Ariad":[1278,1295],"Pharmaceuticals.":[1279,1296],"S.G.":[1280],"receives":[1288],"research":[1289],"support":[1290],"Pfizer,":[1292],"Novartis":[1293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}