{"id":"https://openalex.org/W1970049876","doi":"https://doi.org/10.1007/s12026-009-8143-4","title":"Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons","display_name":"Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons","publication_year":2010,"publication_date":"2010-01-19","ids":{"openalex":"https://openalex.org/W1970049876","doi":"https://doi.org/10.1007/s12026-009-8143-4","mag":"1970049876","pmid":"https://pubmed.ncbi.nlm.nih.gov/20087684","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2891389"},"language":"en","primary_location":{"id":"doi:10.1007/s12026-009-8143-4","doi":"https://doi.org/10.1007/s12026-009-8143-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12026-009-8143-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12026-009-8143-4.pdf","source":{"id":"https://openalex.org/S70378559","display_name":"Immunologic Research","issn_l":"0257-277X","issn":["0257-277X","1559-0755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunologic Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s12026-009-8143-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040754947","display_name":"Diane E. Griffin","orcid":"https://orcid.org/0000-0001-6643-2429","observed_orcids":["https://orcid.org/0000-0001-6643-2429"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane E. Griffin","raw_affiliation_strings":["W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Rm E5132, Baltimore, MD 21205, USA. dgriffin@jhsph.edu","Johns Hopkins Bloomberg School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Rm E5132, Baltimore, MD 21205, USA. dgriffin@jhsph.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040754947"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":null,"fwci":0.7174,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.54878049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"1-3","first_page":"123","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.13590000569820404,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-encephalomyelitis","display_name":"viral encephalomyelitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sindbis-virus","display_name":"Sindbis virus","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.43700000643730164},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.6779999732971191},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.847000002861023},{"id":"https://openalex.org/keywords/brain-neurons","display_name":"brain neurons","score":0.5360000133514404},{"id":"https://openalex.org/keywords/antibody-secreting-cells","display_name":"antibody-secreting cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/viral-rna-persistence","display_name":"viral RNA persistence","score":0.6899999976158142},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/recovery-from-infection","display_name":"recovery from infection","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777343345","wikidata":"https://www.wikidata.org/wiki/Q2302993","display_name":"Sindbis virus","level":4,"score":0.7472568154335022},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7450148463249207},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5986593961715698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.565368115901947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5489330291748047},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.5122711062431335},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5063070058822632},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.5035714507102966},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4934796094894409},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4758431911468506},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.38578134775161743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31841540336608887},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25102198123931885},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17659255862236023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012845","descriptor_name":"Sindbis Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018354","descriptor_name":"Alphavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12026-009-8143-4","doi":"https://doi.org/10.1007/s12026-009-8143-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12026-009-8143-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12026-009-8143-4.pdf","source":{"id":"https://openalex.org/S70378559","display_name":"Immunologic Research","issn_l":"0257-277X","issn":["0257-277X","1559-0755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunologic Research","raw_type":"journal-article"},{"id":"pmid:20087684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20087684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunologic research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2119422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2891389","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2891389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2891389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12026-009-8143-4","doi":"https://doi.org/10.1007/s12026-009-8143-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12026-009-8143-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12026-009-8143-4.pdf","source":{"id":"https://openalex.org/S70378559","display_name":"Immunologic Research","issn_l":"0257-277X","issn":["0257-277X","1559-0755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunologic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7980193082","display_name":"Control of alphavirous replacation in the nervous system","funder_award_id":"R01NS038932","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970049876.pdf","grobid_xml":"https://content.openalex.org/works/W1970049876.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W48783115","https://openalex.org/W125290935","https://openalex.org/W179296264","https://openalex.org/W568493077","https://openalex.org/W1488452721","https://openalex.org/W1493525579","https://openalex.org/W1517159675","https://openalex.org/W1527726281","https://openalex.org/W1546946747","https://openalex.org/W1558647135","https://openalex.org/W1562902980","https://openalex.org/W1585247532","https://openalex.org/W1591334005","https://openalex.org/W1591562094","https://openalex.org/W1855484651","https://openalex.org/W1899341523","https://openalex.org/W1907777909","https://openalex.org/W1911019285","https://openalex.org/W1916576520","https://openalex.org/W1933419033","https://openalex.org/W1946962848","https://openalex.org/W1964017729","https://openalex.org/W1965829947","https://openalex.org/W1966011479","https://openalex.org/W1967473693","https://openalex.org/W1967599371","https://openalex.org/W1972822550","https://openalex.org/W1974367364","https://openalex.org/W1976010325","https://openalex.org/W1982935609","https://openalex.org/W1983177482","https://openalex.org/W1986003731","https://openalex.org/W1988256009","https://openalex.org/W2001275070","https://openalex.org/W2010868420","https://openalex.org/W2016594112","https://openalex.org/W2022340659","https://openalex.org/W2030865745","https://openalex.org/W2031552251","https://openalex.org/W2037301794","https://openalex.org/W2037713473","https://openalex.org/W2043092552","https://openalex.org/W2047684538","https://openalex.org/W2059013205","https://openalex.org/W2067709496","https://openalex.org/W2074910450","https://openalex.org/W2075272059","https://openalex.org/W2080599448","https://openalex.org/W2081133644","https://openalex.org/W2083162753","https://openalex.org/W2093008974","https://openalex.org/W2094899168","https://openalex.org/W2097935692","https://openalex.org/W2105340645","https://openalex.org/W2105360761","https://openalex.org/W2117139370","https://openalex.org/W2119621240","https://openalex.org/W2124474821","https://openalex.org/W2129415910","https://openalex.org/W2134631240","https://openalex.org/W2136628013","https://openalex.org/W2138285726","https://openalex.org/W2138509994","https://openalex.org/W2140369997","https://openalex.org/W2142913420","https://openalex.org/W2146588462","https://openalex.org/W2147999139","https://openalex.org/W2148219821","https://openalex.org/W2151276722","https://openalex.org/W2152532651","https://openalex.org/W2153688420","https://openalex.org/W2154981140","https://openalex.org/W2157748691","https://openalex.org/W2158364751","https://openalex.org/W2160056576","https://openalex.org/W2160315905","https://openalex.org/W2163166100","https://openalex.org/W2163487275","https://openalex.org/W2169121410","https://openalex.org/W2169180468","https://openalex.org/W2169949084","https://openalex.org/W2224063625","https://openalex.org/W2419053233","https://openalex.org/W2469990302","https://openalex.org/W4313376805"],"related_works":["https://openalex.org/W1986432489","https://openalex.org/W2318306686","https://openalex.org/W2117139370","https://openalex.org/W1986003731","https://openalex.org/W2784311615","https://openalex.org/W1976284440","https://openalex.org/W2048257343","https://openalex.org/W2425802568","https://openalex.org/W2084121962","https://openalex.org/W2154981140"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}