{"id":"https://openalex.org/W1970046367","doi":"https://doi.org/10.4161/cbt.4.1.1372","title":"The tumor suppressor p33ING1benhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells","display_name":"The tumor suppressor p33ING1benhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1970046367","doi":"https://doi.org/10.4161/cbt.4.1.1372","mag":"1970046367","pmid":"https://pubmed.ncbi.nlm.nih.gov/15662138"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.4.1.1372","doi":"https://doi.org/10.4161/cbt.4.1.1372","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.1.1372","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.1.1372?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.1.1372?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110049127","display_name":"Jin-Jun Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Jun Zhu","raw_affiliation_strings":["Department of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043428427","display_name":"LI Fo-bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fo-Bao Li","raw_affiliation_strings":["Department of Orthopedic Surgery ; The First Affiliated Hospital ; Sun Yat-sen University ; Guangzhou , China","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery ; The First Affiliated Hospital ; Sun Yat-sen University ; Guangzhou , China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110027025","display_name":"Jun-Min Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Min Zhou","raw_affiliation_strings":["Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109199277","display_name":"Zong-Chao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Chao Liu","raw_affiliation_strings":["Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101587495","display_name":"Xiao\u2010Feng Zhu","orcid":"https://orcid.org/0000-0002-1313-4783","observed_orcids":["https://orcid.org/0000-0002-1313-4783"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Feng Zhu","raw_affiliation_strings":["Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","Experimental Research - State Key Laboratory of Oncology in South China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute; Cancer Center ; Sun Yat-sen University ; Guangzhou , China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Experimental Research - State Key Laboratory of Oncology in South China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100850955","display_name":"Wei-Ming Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei-Ming Liao","raw_affiliation_strings":["Sun Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100850955","https://openalex.org/A5101587495"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768007"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":1.0345,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7610745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"46","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9430000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8529999852180481},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9350000023841858},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/u2os-cells","display_name":"U2OS cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mg-63-cells","display_name":"MG-63 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8117216229438782},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7989153265953064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6262996196746826},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6002697944641113},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5148209929466248},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47019705176353455},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4473511278629303},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4460332989692688},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.43584102392196655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41906043887138367},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40481117367744446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39246439933776855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34912174940109253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07793572545051575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06379890441894531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060407161712646484}],"mesh":[{"descriptor_ui":"D000076023","descriptor_name":"Inhibitor of Growth Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.4.1.1372","doi":"https://doi.org/10.4161/cbt.4.1.1372","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.1.1372","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.1.1372?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},{"id":"pmid:15662138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15662138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.4.1.1372","doi":"https://doi.org/10.4161/cbt.4.1.1372","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.1.1372","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.1.1372?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6492493869","display_name":"p33ING1\u4ecb\u5bfc\u9aa8\u8089\u7624\u53d1\u751f\u7684\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"30070766","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970046367.pdf","grobid_xml":"https://content.openalex.org/works/W1970046367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009287260","https://openalex.org/W2027265029","https://openalex.org/W2417500554","https://openalex.org/W2258976052","https://openalex.org/W3204490709","https://openalex.org/W2238526648","https://openalex.org/W2025066611","https://openalex.org/W2052437545","https://openalex.org/W2077111270","https://openalex.org/W1977194479"],"abstract_inverted_index":{"p33ING1b":[0,14,24,34,62,84,107,118],"can":[1],"stimulate":[2],"cell":[3,47],"cycle":[4],"arrest,":[5],"DNA":[6],"repair,":[7],"apoptosis":[8,51,69,110],"and":[9,17,45,50,68,90,94,130],"chemosensitivity.":[10],"The":[11,58],"actions":[12],"of":[13,31,83,132],"involve":[15],"p53-dependent":[16,112],"p53-independent":[18],"mechanisms.":[19],"To":[20],"investigate":[21],"if":[22],"the":[23,29,128],"isoform":[25],"is":[26],"involved":[27],"in":[28,37,70,76,97,114,127],"chemosensitivity":[30],"osteosarcoma":[32,116],"cells,":[33,44,73],"was":[35],"overexpressed":[36],"p53+/+":[38,71],"U2OS":[39,72,99],"cells":[40],"or":[41],"p53-mutant":[42,77],"MG63":[43,78],"then":[46],"growth":[48,66],"arrest":[49],"were":[52],"assessed":[53],"after":[54],"treatment":[55,131],"with":[56],"taxol.":[57],"results":[59],"showed":[60],"that":[61,106],"markedly":[63],"increased":[64],"taxol-induced":[65,109],"inhibition":[67],"but":[74],"not":[75],"cells.":[79,100,117],"Moreover,":[80],"ectopic":[81],"expression":[82],"could":[85],"obviously":[86],"upregulate":[87],"p53,":[88],"p21WAF1":[89],"bax":[91],"protein":[92],"levels":[93],"activate":[95],"caspase-3":[96],"taxol-treated":[98],"Taken":[101],"together,":[102],"our":[103],"data":[104],"demonstrate":[105],"enhances":[108],"through":[111],"pathway":[113],"human":[115],"may":[119],"be":[120],"an":[121],"important":[122],"marker":[123],"and/or":[124],"therapeutic":[125],"target":[126],"prevention":[129],"osteosarcoma.":[133]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}