{"id":"https://openalex.org/W1970044631","doi":"https://doi.org/10.1118/1.4889194","title":"MO\u2010G\u2010BRF\u201001: BEST IN PHYSICS (JOINT IMAGING\u2010THERAPY) \u2013 Sensitivity of PET\u2010Based Texture Features to Respiratory Motion in Non\u2010Small Cell Lung Cancer (NSCLC)","display_name":"MO\u2010G\u2010BRF\u201001: BEST IN PHYSICS (JOINT IMAGING\u2010THERAPY) \u2013 Sensitivity of PET\u2010Based Texture Features to Respiratory Motion in Non\u2010Small Cell Lung Cancer (NSCLC)","publication_year":2014,"publication_date":"2014-05-29","ids":{"openalex":"https://openalex.org/W1970044631","doi":"https://doi.org/10.1118/1.4889194","mag":"1970044631"},"language":"en","primary_location":{"id":"doi:10.1118/1.4889194","doi":"https://doi.org/10.1118/1.4889194","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4889194","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101785824","display_name":"Stephen S. F. Yip","orcid":"https://orcid.org/0000-0001-8626-5736","observed_orcids":["https://orcid.org/0000-0001-8626-5736"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Yip","raw_affiliation_strings":["Brigham and Womens Hospital, Boston, MA","Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Womens Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947132","display_name":"Keisha C. McCall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K McCall","raw_affiliation_strings":["Brigham and Womens Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Womens Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043619532","display_name":"Michalis Aristophanous","orcid":"https://orcid.org/0000-0001-9117-1515","observed_orcids":["https://orcid.org/0000-0001-9117-1515"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Aristophanous","raw_affiliation_strings":["Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043176593","display_name":"Aileen B. Chen","orcid":"https://orcid.org/0000-0002-5385-3360","observed_orcids":["https://orcid.org/0000-0002-5385-3360"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Chen","raw_affiliation_strings":["UT/MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT/MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001452511","display_name":"Hugo J.W.L. Aerts","orcid":"https://orcid.org/0000-0002-2122-2003","observed_orcids":["https://orcid.org/0000-0002-2122-2003"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Aerts","raw_affiliation_strings":["Brigham and Womens Hospital, Boston, MA","Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Womens Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107835874","display_name":"R. Berbeco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Berbeco","raw_affiliation_strings":["Brigham and Womens Hospital, Boston, MA","Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Womens Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08280933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"6Part25","first_page":"434","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-motion","display_name":"respiratory motion","score":0.9089999794960022},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/4d-pet","display_name":"4D PET","score":0.753000020980835},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.7919999957084656},{"id":"https://openalex.org/keywords/movement-amplitude","display_name":"movement amplitude","score":0.6949999928474426},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.4620000123977661},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/treatment-outcome-prediction","display_name":"treatment outcome prediction","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.656985878944397},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6202912330627441},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.6070964336395264},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.5164411067962646},{"id":"https://openalex.org/C2781195486","wikidata":"https://www.wikidata.org/wiki/Q289436","display_name":"Texture (cosmology)","level":3,"score":0.5109490752220154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5000252723693848},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.490792840719223},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4882669448852539},{"id":"https://openalex.org/C101601086","wikidata":"https://www.wikidata.org/wiki/Q3753228","display_name":"Rank correlation","level":2,"score":0.4880574941635132},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4855956435203552},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.48222434520721436},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4528348445892334},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3436882495880127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3159397840499878},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.25434547662734985},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20611628890037537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1801745593547821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1800588071346283},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15821701288223267},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.1458701193332672},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0752667486667633},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1118/1.4889194","doi":"https://doi.org/10.1118/1.4889194","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4889194","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106903895","https://openalex.org/W7099383355","https://openalex.org/W2116881174","https://openalex.org/W2063965479","https://openalex.org/W2562146120","https://openalex.org/W2473108973","https://openalex.org/W2766108220","https://openalex.org/W2088378003","https://openalex.org/W2793450646","https://openalex.org/W2189880677"],"abstract_inverted_index":{"Purpose:":[0],"PET\u2010based":[1],"texture":[2,23,69,126,226],"features":[3,24,70,127,227],"are":[4],"used":[5,104,119,136],"to":[6,11,25,62,105,120,137,188],"quantify":[7],"tumor":[8,26,82,142,220],"heterogeneity":[9],"due":[10],"their":[12],"predictive":[13],"power":[14],"in":[15,88,124,253],"treatment":[16],"outcome.":[17],"We":[18],"investigated":[19],"the":[20,64,79,80,92,122,125,139,197,219,225,263],"sensitivity":[21],"of":[22,115,141],"motion":[27,145,290],"by":[28,288,298],"comparing":[29],"whole":[30],"body":[31],"(3D)":[32],"and":[33,45,74,94,144,155,163,177,180,184,203,211,222,238,242,247,259,270],"respiratory\u2010gated":[34],"(4D)":[35],"PET":[36],"imaging.":[37,261],"Methods:":[38],"Twenty\u2010six":[39],"patients":[40],"(34":[41],"lesions)":[42],"received":[43],"3D":[44,154,258],"4D":[46,53,65,156,198],"[F\u201018]FDG\u2010PET":[47],"scans":[48],"before":[49],"chemo\u2010radiotherapy.":[50],"The":[51,84,165],"acquired":[52],"data":[54],"were":[55,76,158,255],"retrospectively":[56],"binned":[57],"into":[58],"five":[59],"breathing":[60],"phases":[61],"create":[63],"image":[66],"sequence.":[67],"Four":[68],"(Coarseness,":[71],"Contrast,":[72],"Busyness,":[73,162],"Complexity)":[75],"computed":[77],"within":[78],"physician\u2010defined":[81],"volume.":[83],"relative":[85],"difference":[86,166],"(\u03b4)":[87],"each":[89],"measure":[90],"between":[91,128,153,196,218,257,265],"3D\u2010":[93],"4D\u2010PET":[95,130,173,260,299],"imaging":[96,157,300],"was":[97,103,109,118,135,169,194,207,216,272],"calculated.":[98],"Wilcoxon":[99],"signed\u2010rank":[100],"test":[101],"(p<0.01)":[102],"determine":[106,121],"if":[107],"\u03b4":[108,223,235],"significantly":[110],"different":[111],"from":[112,281],"zero.":[113],"Coefficient":[114],"variation":[116],"(CV)":[117],"variability":[123,192,206,264],"all":[129,282],"phases.":[131,283],"Pearson":[132],"correlation":[133,215],"coefficient":[134],"investigate":[138],"impact":[140,233,244],"size":[143],"amplitude":[146,230],"on":[147,234],"\u03b4.":[148],"Results:":[149],"Significant":[150],"differences":[151,252],"(p<<0.01)":[152],"found":[159,195,208,217,256],"for":[160,167,201,209,224,236,245,268],"Coarseness,":[161],"Complexity.":[164,204],"Contrast":[168,185,210,237],"not":[170],"significant":[171],"(p>0.24).":[172],"increased":[174],"Busyness":[175,212,239],"(\u223c20%)":[176],"Complexity":[178,248,271],"(\u223c20%),":[179],"decreased":[181],"Coarseness":[182,202,246,269],"(\u223c10%)":[183],"(\u223c5%)":[186],"compared":[187],"3D\u2010PET.":[189],"Nearly":[190],"negligible":[191],"(CV=3.9%)":[193],"phase":[199,266],"bins":[200,267],"Moderate":[205],"(CV\u223c10%).":[213],"Poor":[214],"volume":[221],"(R=\u22120.34\u22120.34).":[228],"Motion":[229],"had":[231],"moderate":[232],"(R=\u22120.64\u2212":[240],"0.54)":[241],"no":[243],"(R=\u22120.29\u22120.17).":[249],"Conclusion:":[250],"Substantial":[251],"textures":[254],"Moreover,":[262],"negligible,":[273],"suggesting":[274],"that":[275],"similar":[276],"quantification":[277],"can":[278,294],"be":[279,295],"obtained":[280],"Texture":[284],"features,":[285],"blurred":[286],"out":[287],"respiratory":[289],"during":[291],"3D\u2010PET":[292],"acquisition,":[293],"better":[296],"resolved":[297],"with":[301],"any":[302],"phase.":[303]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}