{"id":"https://openalex.org/W1969939160","doi":"https://doi.org/10.1371/journal.pone.0008294","title":"Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/\u03b2-Catenin Pathway","display_name":"Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/\u03b2-Catenin Pathway","publication_year":2009,"publication_date":"2009-12-11","ids":{"openalex":"https://openalex.org/W1969939160","doi":"https://doi.org/10.1371/journal.pone.0008294","mag":"1969939160","pmid":"https://pubmed.ncbi.nlm.nih.gov/20011538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789382"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0008294","doi":"https://doi.org/10.1371/journal.pone.0008294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0008294","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008294&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008294&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002746491","display_name":"Desheng Lu","orcid":"https://orcid.org/0000-0002-0314-5649","observed_orcids":["https://orcid.org/0000-0002-0314-5649"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Desheng Lu","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America. delu@ucsd.edu","Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America. delu@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024545891","display_name":"Jerry X. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry X. Liu","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011953330","display_name":"Tomoyuki Endo","orcid":"https://orcid.org/0000-0002-2800-2492","observed_orcids":["https://orcid.org/0000-0002-2800-2492","https://orcid.org/0000-0001-8462-8281"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoyuki Endo","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082486313","display_name":"Haowen Zhou","orcid":"https://orcid.org/0000-0001-9678-1865","observed_orcids":["https://orcid.org/0000-0001-9678-1865"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haowen Zhou","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023081986","display_name":"Shiyin Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiyin Yao","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056303400","display_name":"Karl Willert","orcid":"https://orcid.org/0000-0002-8020-6804","observed_orcids":["https://orcid.org/0000-0002-8020-6804"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Willert","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111590964","display_name":"Ingo G.H. Schmidt\u2010Wolf","orcid":"https://orcid.org/0000-0002-5655-0867","observed_orcids":["https://orcid.org/0000-0002-5655-0867"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo G. H. Schmidt-Wolf","raw_affiliation_strings":["Center for Integrated Oncology, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrated Oncology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Kipps","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086448751","display_name":"Dennis Anthony Carson","orcid":"https://orcid.org/0000-0001-5273-0804","observed_orcids":["https://orcid.org/0000-0001-5273-0804"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis A. Carson","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002746491","https://openalex.org/A5086448751"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.1094,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.86702299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"4","issue":"12","first_page":"e8294","last_page":"e8294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethacrynic-acid","display_name":"ethacrynic acid","score":1.0},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lef1","display_name":"LEF1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.6769999861717224},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.699999988079071},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9350072145462036},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5370492339134216},{"id":"https://openalex.org/C99732316","wikidata":"https://www.wikidata.org/wiki/Q18032812","display_name":"AXIN2","level":4,"score":0.5082423090934753},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.47673356533050537},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4765799045562744},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.43450161814689636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4181329905986786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41519731283187866},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41398465633392334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39707323908805847},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.36569422483444214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16641104221343994},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1478903889656067}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004976","descriptor_name":"Ethacrynic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051821","descriptor_name":"Lymphoid Enhancer-Binding Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051821","descriptor_name":"Lymphoid Enhancer-Binding Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0008294","doi":"https://doi.org/10.1371/journal.pone.0008294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0008294","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008294&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1895549","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789382","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2789382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789382","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20011538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20011538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.357.373","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.357.373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c4/13/PLoS_One_2009_Dec_14_4(12)_e8294.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:209b7c9f1e9a401ebf47daad7ff7a248","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/209b7c9f1e9a401ebf47daad7ff7a248","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 12, p e8294 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0008294","doi":"https://doi.org/10.1371/journal.pone.0008294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0008294","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008294&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1395449595","display_name":null,"funder_award_id":"CA81534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2443312090","display_name":null,"funder_award_id":"CA081534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4196283660","display_name":null,"funder_award_id":"PO1-CA081534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6074654903","display_name":"Apoptosis-Based Cancer Drug Discovery","funder_award_id":"U19CA113318","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6531675111","display_name":null,"funder_award_id":"CA81534-06","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7166836526","display_name":null,"funder_award_id":"CA113318-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8225889400","display_name":"Chronic Lymphocytic Leukemia Research Consortium","funder_award_id":"4p01ca081534-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000039546","display_name":null,"funder_award_id":"PO1-CA081534","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G944802235","display_name":null,"funder_award_id":"P01-CA-081534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969939160.pdf","grobid_xml":"https://content.openalex.org/works/W1969939160.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W33582663","https://openalex.org/W1499230593","https://openalex.org/W1554815317","https://openalex.org/W1847040016","https://openalex.org/W1963037702","https://openalex.org/W1967803088","https://openalex.org/W1981766282","https://openalex.org/W1983755269","https://openalex.org/W1985304309","https://openalex.org/W2001857107","https://openalex.org/W2023192965","https://openalex.org/W2031049356","https://openalex.org/W2033020636","https://openalex.org/W2035474025","https://openalex.org/W2035809306","https://openalex.org/W2043289628","https://openalex.org/W2043417066","https://openalex.org/W2045205376","https://openalex.org/W2052661123","https://openalex.org/W2069021241","https://openalex.org/W2071397057","https://openalex.org/W2080616952","https://openalex.org/W2087314695","https://openalex.org/W2089068494","https://openalex.org/W2090792585","https://openalex.org/W2094484000","https://openalex.org/W2097895666","https://openalex.org/W2099348990","https://openalex.org/W2103006179","https://openalex.org/W2107648723","https://openalex.org/W2108247331","https://openalex.org/W2109069210","https://openalex.org/W2145132518","https://openalex.org/W2146163922","https://openalex.org/W2147864074","https://openalex.org/W2150902176","https://openalex.org/W2151230965","https://openalex.org/W2156490871","https://openalex.org/W2221262359","https://openalex.org/W2314458206","https://openalex.org/W2417114995","https://openalex.org/W2463647090","https://openalex.org/W4210446856","https://openalex.org/W4233375858","https://openalex.org/W4255248537","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W7101053240","https://openalex.org/W2980139923","https://openalex.org/W2289819422","https://openalex.org/W2562028234","https://openalex.org/W2033020636","https://openalex.org/W2097489570","https://openalex.org/W1957142224","https://openalex.org/W2023192965","https://openalex.org/W2551577401","https://openalex.org/W2563530584"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aberrant":[1],"activation":[2,165],"of":[3,9,88,108,116,163,188,206],"Wnt/beta-catenin":[4,32,91,117,164,189],"signaling":[5,19,33,48,193],"promotes":[6],"the":[7,17,37,46,85,114,140,149,160],"development":[8],"several":[10],"cancers.":[11],"It":[12],"has":[13],"been":[14],"demonstrated":[15,129],"that":[16,30,41,97,130,179],"Wnt":[18,47,72,77,192],"pathway":[20,49],"is":[21,50],"activated":[22],"in":[23,39,103,153,172,194],"chronic":[24],"lymphocytic":[25],"leukemia":[26],"(CLL)":[27],"cells,":[28],"and":[29,124,138,166],"uncontrolled":[31],"may":[34,201],"contribute":[35],"to":[36,111,135,169,186],"defect":[38],"apoptosis":[40,171],"characterizes":[42],"this":[43,207],"malignancy.":[44],"Thus,":[45],"an":[51,203],"attractive":[52],"candidate":[53],"for":[54,58],"developing":[55],"targeted":[56],"therapies":[57],"CLL.":[59],"METHODOLOGY/PRINCIPAL":[60],"FINDINGS:":[61],"The":[62],"diuretic":[63],"agent":[64],"ethacrynic":[65],"acid":[66],"(EA)":[67],"was":[68],"identified":[69],"as":[70],"a":[71,75],"inhibitor":[73],"using":[74],"cell-based":[76],"reporter":[78],"assay.":[79],"In":[80],"vitro":[81],"assays":[82,95],"further":[83],"confirmed":[84],"inhibitory":[86],"effect":[87],"EA":[89,98,112,131,180,197],"on":[90],"signaling.":[92,190],"Cell":[93],"viability":[94],"showed":[96],"selectively":[99,181],"induced":[100],"cell":[101],"death":[102],"primary":[104],"CLL":[105,109,173,183,195],"cells.":[106,174],"Exposure":[107],"cells":[110],"decreased":[113],"expression":[115],"target":[118],"genes,":[119],"including":[120],"LEF-1,":[121],"cyclin":[122],"D1":[123],"fibronectin.":[125],"Immune":[126],"co-precipitation":[127],"experiments":[128],"could":[132],"directly":[133],"bind":[134],"LEF-1":[136],"protein":[137],"destabilize":[139],"LEF-1/beta-catenin":[141],"complex.":[142],"N-acetyl-L-cysteine":[143],"(NAC),":[144],"which":[145],"can":[146],"react":[147],"with":[148,196],"alpha,":[150],"beta-unsaturated":[151],"ketone":[152],"EA,":[154],"but":[155],"not":[156],"other":[157],"anti-oxidants,":[158],"prevented":[159],"drug's":[161],"inhibition":[162,187],"its":[167],"ability":[168],"induce":[170],"CONCLUSIONS/SIGNIFICANCE:":[175],"Our":[176],"studies":[177],"indicate":[178],"suppresses":[182],"survival":[184],"due":[185],"Antagonizing":[191],"or":[198],"related":[199],"drugs":[200],"represent":[202],"effective":[204],"treatment":[205],"disease.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}