{"id":"https://openalex.org/W1969936624","doi":"https://doi.org/10.1186/1471-2334-14-272","title":"Bloodstream infections and sepsis in Greece: over-time change of epidemiology and impact of de-escalation on final outcome","display_name":"Bloodstream infections and sepsis in Greece: over-time change of epidemiology and impact of de-escalation on final outcome","publication_year":2014,"publication_date":"2014-05-18","ids":{"openalex":"https://openalex.org/W1969936624","doi":"https://doi.org/10.1186/1471-2334-14-272","mag":"1969936624","pmid":"https://pubmed.ncbi.nlm.nih.gov/24885072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4035827"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2334-14-272","doi":"https://doi.org/10.1186/1471-2334-14-272","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-272","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-14-272","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-14-272","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025386415","display_name":"Marina Koupetori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123311","display_name":"Thriasio General Hospital of Elefsina","ror":"https://ror.org/035e8e276","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210123311"]},{"id":"https://openalex.org/I4405268967","display_name":"Hellenic Institute for the Study of Sepsis","ror":"https://ror.org/02n4vr545","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4405268967"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Marina Koupetori","raw_affiliation_strings":["1st Department of Internal Medicine, Thriassio General Hospital, Elefsis, Greece","the Hellenic Sepsis Study Group, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, Thriassio General Hospital, Elefsis, Greece","institution_ids":["https://openalex.org/I4210123311"]},{"raw_affiliation_string":"the Hellenic Sepsis Study Group, Greece","institution_ids":["https://openalex.org/I4405268967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042171080","display_name":"Theodoros A. Retsas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodoros Retsas","raw_affiliation_strings":["Department of Therapeutics, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutics, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034837078","display_name":"Nikolaos Antonakos","orcid":"https://orcid.org/0000-0002-7552-5878","observed_orcids":["https://orcid.org/0000-0002-7552-5878"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Antonakos","raw_affiliation_strings":["4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048535218","display_name":"G. Vlachogiannis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glykeria Vlachogiannis","raw_affiliation_strings":["Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Aghios Dimitrios General Hospital, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041109504","display_name":"Ioannis Perdios","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis Perdios","raw_affiliation_strings":["Intensive Care Unit, Artas General Hospital, Artas, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Artas General Hospital, Artas, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067070313","display_name":"Christos Nathanail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]},{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Nathanail","raw_affiliation_strings":["Department of Internal Medicine, General Hospital of the University of Thessaly, Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, General Hospital of the University of Thessaly, Larissa, Greece","institution_ids":["https://openalex.org/I145722265","https://openalex.org/I4210107217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021615854","display_name":"Konstantinos P. Makaritsis","orcid":"https://orcid.org/0000-0002-8675-6583","observed_orcids":["https://orcid.org/0000-0002-8675-6583"]},"institutions":[{"id":"https://openalex.org/I4210105465","display_name":"General Hospital of Athens G. Genimatas","ror":"https://ror.org/00zq17821","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105465"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Makaritsis","raw_affiliation_strings":["1st Department of Internal Medicine, G.Gennimatas General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, G.Gennimatas General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210105465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071545285","display_name":"Antonios Papadopoulos","orcid":"https://orcid.org/0000-0003-4735-2620","observed_orcids":["https://orcid.org/0000-0003-4735-2620"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonios Papadopoulos","raw_affiliation_strings":["4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111532649","display_name":"Dimitrios Sinapidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Sinapidis","raw_affiliation_strings":["Department of Therapeutics, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutics, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011316933","display_name":"Evangelos J. Giamarellos\u2010Bourboulis","orcid":"https://orcid.org/0000-0003-4713-3911","observed_orcids":["https://orcid.org/0000-0003-4713-3911"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Evangelos J Giamarellos-Bourboulis","raw_affiliation_strings":["4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462 Athens, Greece. egiamarel@med.uoa.gr","4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462 Athens, Greece. egiamarel@med.uoa.gr","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039133614","display_name":"Ioannis A Pneumatikos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161335","display_name":"University Hospital of Alexandroupolis","ror":"https://ror.org/04zkctn64","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210161335"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Pneumatikos","raw_affiliation_strings":["Intensive Care Unit, Democriteion University Hospital, Alexandroupolis, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Democriteion University Hospital, Alexandroupolis, Greece","institution_ids":["https://openalex.org/I4210161335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108523771","display_name":"Charalambos A. Gogos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalambos Gogos","raw_affiliation_strings":["Department of Internal Medicine, University of Patras, Rion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Patras, Rion, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047217664","display_name":"Apostolos Armaganidis","orcid":"https://orcid.org/0000-0002-6630-2648","observed_orcids":["https://orcid.org/0000-0002-6630-2648"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Apostolos Armaganidis","raw_affiliation_strings":["2nd Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061573820","display_name":"Elisabeth Paramythiotou","orcid":"https://orcid.org/0000-0001-5779-6597","observed_orcids":["https://orcid.org/0000-0001-5779-6597"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elisabeth Paramythiotou","raw_affiliation_strings":["2nd Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Critical Care Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5011316933"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":6.0372,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96552583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"272","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bloodstream-infection","display_name":"bloodstream infection","score":0.996999979019165},{"id":"https://openalex.org/keywords/antimicrobial-de-escalation","display_name":"antibiotic de-escalation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/empirical-antimicrobial-therapy","display_name":"empirical antimicrobial therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/multidrug-resistant-pathogens","display_name":"multidrug-resistant pathogens","score":0.8730000257492065},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.699999988079071},{"id":"https://openalex.org/keywords/sepsis-epidemiology","display_name":"sepsis epidemiology","score":0.7049999833106995},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.7260000109672546},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.597000002861023},{"id":"https://openalex.org/keywords/general-wards","display_name":"general wards","score":0.800000011920929},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hemofiltration","display_name":"hemofiltration","score":0.8849999904632568},{"id":"https://openalex.org/keywords/long-term-care-facilities","display_name":"long-term care facilities","score":0.8790000081062317},{"id":"https://openalex.org/keywords/greece","display_name":"Greece","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.8388228416442871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7807940244674683},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7786684036254883},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6599958539009094},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6317853331565857},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5561166405677795},{"id":"https://openalex.org/C2776056953","wikidata":"https://www.wikidata.org/wiki/Q1182511","display_name":"De-escalation","level":2,"score":0.519314706325531},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.4594991207122803},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.42253583669662476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4025476276874542},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3504253029823303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21520090103149414},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.11348658800125122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09209391474723816},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008134","descriptor_name":"Long-Term Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2334-14-272","doi":"https://doi.org/10.1186/1471-2334-14-272","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-272","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-14-272","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3009485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4035827","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24885072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24885072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4035827","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4035827/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infect Dis","raw_type":"Text"},{"id":"pmh:oai:ir.lib.uth.gr:11615/29832","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11615/29832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400243","display_name":"University of Thessaly Institutional Repository (University of Thessaly)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145722265","host_organization_name":"University of Thessaly","host_organization_lineage":["https://openalex.org/I145722265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.scopus.com/inward/record.url?eid=2-s2.0-84901602158&amp;partnerID=40&amp;md5=0404c64dc5885b7246585a24698478c1","raw_type":"journalArticle"}],"best_oa_location":{"id":"doi:10.1186/1471-2334-14-272","doi":"https://doi.org/10.1186/1471-2334-14-272","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-272","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-14-272","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969936624.pdf","grobid_xml":"https://content.openalex.org/works/W1969936624.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1927106291","https://openalex.org/W2025245931","https://openalex.org/W2050939778","https://openalex.org/W2076526761","https://openalex.org/W2079537401","https://openalex.org/W2087203965","https://openalex.org/W2088022538","https://openalex.org/W2092408753","https://openalex.org/W2092802285","https://openalex.org/W2097563038","https://openalex.org/W2100536943","https://openalex.org/W2107810227","https://openalex.org/W2120048783","https://openalex.org/W2125737144","https://openalex.org/W2125789788","https://openalex.org/W2133736418","https://openalex.org/W2141582183","https://openalex.org/W2162282209","https://openalex.org/W2165158988","https://openalex.org/W2168409658","https://openalex.org/W2397664387","https://openalex.org/W2419509696","https://openalex.org/W2442246762","https://openalex.org/W2581605534","https://openalex.org/W3023757607","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2334342838","https://openalex.org/W4405224960","https://openalex.org/W4406955112","https://openalex.org/W1973005960","https://openalex.org/W3133446450","https://openalex.org/W4413433551","https://openalex.org/W2972682858","https://openalex.org/W3096616577","https://openalex.org/W4402205935","https://openalex.org/W2788630981"],"abstract_inverted_index":{"BACKGROUND:":[0],"Choice":[1],"of":[2,15,79,97,131,136,141,161,203],"empirically":[3],"prescribed":[4],"antimicrobials":[5],"for":[6],"sepsis":[7,16,50,63,127,204],"management":[8],"depends":[9],"on":[10,99],"epidemiological":[11,186],"factors.":[12],"The":[13,73,201],"epidemiology":[14,80,202],"in":[17,21,39,43,52,57,67,120,174,191,197,205,208,212,216],"Greece":[18,206],"was":[19,37,94],"studied":[20],"two":[22],"large-periods.":[23],"METHODS:":[24],"Sepsis":[25],"due":[26],"to":[27],"bloodstream":[28],"infections":[29],"(BSI)":[30],"from":[31,108,112],"July":[32],"2006":[33],"until":[34],"March":[35],"2013":[36],"recorded":[38,117],"a":[40,145,220],"multicenter":[41],"study":[42],"46":[44],"departments.":[45],"Patients":[46],"were":[47,76,105,116,157,188],"divided":[48],"into":[49,169],"admitted":[51],"the":[53,58,68,77,82,91,95,121,129,134,139,163,192,209,213,217],"emergencies":[54],"and":[55,62,81,110,147,167,211],"hospitalized":[56],"general":[59],"ward":[60],"(GW)":[61],"developing":[64],"after":[65],"admission":[66],"Intensive":[69],"Care":[70],"Unit":[71],"(ICU).":[72],"primary":[74],"endpoints":[75],"changes":[78],"factors":[83],"related":[84,151],"with":[85,152],"BSIs":[86,175],"by":[87,154,176],"multidrug-resistant":[88],"(MDR)":[89],"pathogens;":[90],"secondary":[92],"endpoint":[93],"impact":[96],"de-escalation":[98],"antimicrobial":[100],"therapy.":[101],"RESULTS:":[102],"754":[103],"patients":[104],"studied;":[106],"378":[107],"2006-2009":[109],"376":[111],"2010-2013.":[113],"Major":[114],"differences":[115,187],"between":[118],"periods":[119],"GW.":[122],"They":[123],"involved":[124],"increase":[125],"of:":[126],"severity;":[128],"incidence":[130,135],"underlying":[132],"diseases;":[133],"polymicrobial":[137],"infections;":[138],"emergence":[140],"Klebsiella":[142],"pneumoniae":[143],"as":[144],"pathogen;":[146],"mortality.":[148],"Factors":[149],"independently":[150],"BSI":[153],"MDR":[155,194],"pathogens":[156],"chronic":[158],"hemofiltration,":[159],"intake":[160],"antibiotics":[162],"last":[164],"three":[165],"months":[166],"residence":[168],"long-term":[170],"care":[171],"facilities.":[172],"De-escalation":[173,215],"fully":[177],"susceptible":[178],"Gram-negatives":[179,195],"did":[180],"not":[181,189],"affect":[182],"final":[183],"outcome.":[184],"Similar":[185],"found":[190],"ICU;":[193],"predominated":[196],"both":[198],"periods.":[199],"CONCLUSIONS:":[200],"differs":[207],"GW":[210,218],"ICU.":[214],"is":[219],"safe":[221],"strategy.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
