{"id":"https://openalex.org/W1969928727","doi":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","title":"The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial","display_name":"The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial","publication_year":2004,"publication_date":"2004-12-13","ids":{"openalex":"https://openalex.org/W1969928727","doi":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","mag":"1969928727","pmid":"https://pubmed.ncbi.nlm.nih.gov/15649655"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2004.11.025","doi":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108128047","display_name":"Jaakko Mursu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Jaakko Mursu","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. jaakko.mursu@uku.fi","Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. jaakko.mursu@uku.fi","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415950","display_name":"Sari Voutilainen","orcid":"https://orcid.org/0000-0001-5330-3847","observed_orcids":["https://orcid.org/0000-0001-5330-3847"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sari Voutilainen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008843420","display_name":"Tarja Nurmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tarja Nurmi","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082107319","display_name":"Georg Alfthan","orcid":"https://orcid.org/0000-0002-4995-5444","observed_orcids":["https://orcid.org/0000-0002-4995-5444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg Alfthan","raw_affiliation_strings":["Biomarker Laboratory, National Public Health Institute, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomarker Laboratory, National Public Health Institute, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043064517","display_name":"Jyrki K. Virtanen","orcid":"https://orcid.org/0000-0002-0648-999X","observed_orcids":["https://orcid.org/0000-0002-0648-999X"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jyrki K. Virtanen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088646398","display_name":"Tiina Rissanen","orcid":"https://orcid.org/0000-0003-1401-8458","observed_orcids":["https://orcid.org/0000-0003-1401-8458"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tiina H. Rissanen","raw_affiliation_strings":["Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026912249","display_name":"Pertti Happonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pertti Happonen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113947222","display_name":"Kristiina Nyyss\u00f6nen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kristiina Nyyss\u00f6nen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959968","display_name":"Jari Kaikkonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jari Kaikkonen","raw_affiliation_strings":["Jurilab Ltd, Kuopio, Finland","Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jurilab Ltd, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567710","display_name":"Riitta M. Salonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riitta Salonen","raw_affiliation_strings":["Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107832557","display_name":"Jukka T. Salonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jukka T. Salonen","raw_affiliation_strings":["Jurilab Ltd, Kuopio, Finland","Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jurilab Ltd, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108128047"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":2.2598,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.85926496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"4","first_page":"527","last_page":"534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coffee-consumption","display_name":"coffee consumption","score":0.9890000224113464},{"id":"https://openalex.org/keywords/filtered-coffee","display_name":"filtered coffee","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.8450000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.925000011920929},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/caffeic-acid","display_name":"caffeic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ferulic-acid","display_name":"ferulic acid","score":1.0},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7848459482192993},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.636123538017273},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6150108575820923},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.5545265078544617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5262067914009094},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5065089464187622},{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.4673241674900055},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43765848875045776},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.40822216868400574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26855331659317017}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003069","descriptor_name":"Coffee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2004.11.025","doi":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2004.11.025","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:15649655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15649655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:www.julkari.fi:10024/85915","doi":null,"is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/85915","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"A"},{"id":"mag:2787144254","doi":null,"is_oa":false,"landing_page_url":"https://www.uef.fi/documents/1099424/1377719/Jaakko_coffee.pdf/8187627c-306e-4561-9e19-add731ef12f2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1857052429","https://openalex.org/W1912228249","https://openalex.org/W1914622032","https://openalex.org/W1937169612","https://openalex.org/W1966368391","https://openalex.org/W1988495446","https://openalex.org/W1995931698","https://openalex.org/W1999825247","https://openalex.org/W2001648413","https://openalex.org/W2041661268","https://openalex.org/W2042203706","https://openalex.org/W2056102929","https://openalex.org/W2057902127","https://openalex.org/W2069584550","https://openalex.org/W2085860656","https://openalex.org/W2091094762","https://openalex.org/W2105234557","https://openalex.org/W2125712619","https://openalex.org/W2137832364","https://openalex.org/W2139399563","https://openalex.org/W2140168790","https://openalex.org/W2143469466","https://openalex.org/W2156716051","https://openalex.org/W2159506419","https://openalex.org/W2160004137","https://openalex.org/W2161198565","https://openalex.org/W2161447669","https://openalex.org/W2183468673","https://openalex.org/W2290967234","https://openalex.org/W2345897054","https://openalex.org/W2420687755"],"related_works":["https://openalex.org/W2787144254","https://openalex.org/W2150704085","https://openalex.org/W1906660648","https://openalex.org/W4250242854","https://openalex.org/W7096015663","https://openalex.org/W4299378273","https://openalex.org/W2071394358","https://openalex.org/W2056102929","https://openalex.org/W2188283979","https://openalex.org/W7196928276"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}