{"id":"https://openalex.org/W1969923322","doi":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","title":"Prostaglandin E 1 as a hypotensive drug during general anaesthesia","display_name":"Prostaglandin E 1 as a hypotensive drug during general anaesthesia","publication_year":1982,"publication_date":"1982-05-01","ids":{"openalex":"https://openalex.org/W1969923322","doi":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","mag":"1969923322","pmid":"https://pubmed.ncbi.nlm.nih.gov/7200736"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2044.1982.tb01222.x","doi":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","pdf_url":null,"source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111672513","display_name":"Fumio Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F. GOTO","raw_affiliation_strings":["Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025398628","display_name":"Eisho Otani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E. OTANI","raw_affiliation_strings":["Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033840272","display_name":"Seiji Kato","orcid":"https://orcid.org/0000-0001-7597-0886","observed_orcids":["https://orcid.org/0000-0001-7597-0886"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. KATO","raw_affiliation_strings":["Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112159237","display_name":"Tatsushi Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. FUJITA","raw_affiliation_strings":["Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fumio Goto, MD, PhD, Department of Anesthesiology, School of Medicine, Gunma University, Eisho Otani, MD, Department of Anesthesiology, Gunma University, Seiji Kato, MD, Department of Anesthesiology, Gunma Cancer Center, Tatsushi Fujita, MD, PhD, Department of Anesthesiology, Gunma University, Showamachi 3-39-22, Maebashi, Gunma 371, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":{"value":4970,"currency":"USD","value_usd":4970},"apc_paid":null,"fwci":1.4033,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.76533997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"5","first_page":"530","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3822999894618988,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.24459999799728394,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.21660000085830688,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e1","display_name":"prostaglandin E1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.7080000042915344},{"id":"https://openalex.org/keywords/halothane-anesthesia","display_name":"halothane anesthesia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.859000027179718},{"id":"https://openalex.org/keywords/arterial-pressure-control","display_name":"arterial pressure control","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mastectomy","display_name":"mastectomy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/intraoperative-blood-loss","display_name":"intraoperative blood loss","score":0.7279999852180481},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5820000171661377},{"id":"https://openalex.org/keywords/left-ventricular-ejection-time","display_name":"left ventricular ejection time","score":0.6859999895095825},{"id":"https://openalex.org/keywords/pre-ejection-period","display_name":"pre-ejection period","score":0.7570000290870667},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9610495567321777},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7904497981071472},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7567248344421387},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.5981916189193726},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5043538808822632},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14441058039665222}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000769","descriptor_name":"Anesthesia, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007023","descriptor_name":"Hypotension, Controlled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014294","descriptor_name":"Trimethaphan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2044.1982.tb01222.x","doi":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1982.tb01222.x","pdf_url":null,"source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},{"id":"pmid:7200736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7200736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1973681299","https://openalex.org/W1978528065","https://openalex.org/W1983775202","https://openalex.org/W1991751482","https://openalex.org/W1994674101","https://openalex.org/W2011364895","https://openalex.org/W2019393655","https://openalex.org/W2042890988","https://openalex.org/W2069763053","https://openalex.org/W2070555116","https://openalex.org/W2073886383","https://openalex.org/W2075300003","https://openalex.org/W2076427783","https://openalex.org/W2088967729","https://openalex.org/W2091031381","https://openalex.org/W2127266930","https://openalex.org/W2138423613","https://openalex.org/W2142584844","https://openalex.org/W2145356084","https://openalex.org/W2175839910","https://openalex.org/W2255260794","https://openalex.org/W2345646843","https://openalex.org/W2407288692","https://openalex.org/W2437387905","https://openalex.org/W4366066231","https://openalex.org/W6691671497"],"related_works":["https://openalex.org/W2089047396","https://openalex.org/W7219434022","https://openalex.org/W1757178465","https://openalex.org/W1991960066","https://openalex.org/W2008857446","https://openalex.org/W2001225147","https://openalex.org/W4247418133","https://openalex.org/W2026961288","https://openalex.org/W1981831865","https://openalex.org/W2026508336"],"abstract_inverted_index":{"Hypotension":[0],"induced":[1,34],"by":[2],"prostaglandin":[3],"E1":[4],"(PGE1)":[5],"infusion":[6,42],"(100-150":[7],"ng/kg/minute)":[8],"during":[9,17,63,78,87,105],"halothane":[10],"anaesthesia":[11],"to":[12,48,101],"reduce":[13],"operative":[14],"blood":[15,45],"loss":[16,86],"mastectomy":[18],"was":[19,36,43,82,89],"investigated.":[20],"PGE1":[21,64,96],"decreased":[22],"systolic":[23],"arterial":[24,103],"pressure":[25,46,104],"approximately":[26],"34%":[27],"from":[28],"pre-administration":[29],"values.":[30],"The":[31],"duration":[32],"of":[33,51],"hypotension":[35],"about":[37],"75":[38],"minutes.":[39,56],"When":[40],"the":[41,52,66,79],"stopped,":[44],"returned":[47],"within":[49],"15%":[50],"control":[53,102],"with":[54],"15":[55],"Heart":[57],"rate":[58],"did":[59],"not":[60],"change":[61],"significantly":[62,90],"infusion;":[65],"pre-ejection":[67],"period":[68,73,81],"and":[69],"left":[70],"ventricular":[71],"ejection":[72],"were":[74],"shortened.":[75],"Renal":[76],"function":[77],"hypotensive":[80],"well":[83],"maintained.":[84],"Blood":[85],"surgery":[88],"decreased.":[91],"These":[92],"findings":[93],"suggest":[94],"that":[95],"can":[97],"be":[98],"used":[99],"safely":[100],"surgery.":[106]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
