{"id":"https://openalex.org/W1969908088","doi":"https://doi.org/10.1021/ac502629r","title":"Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals","display_name":"Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals","publication_year":2014,"publication_date":"2014-12-15","ids":{"openalex":"https://openalex.org/W1969908088","doi":"https://doi.org/10.1021/ac502629r","mag":"1969908088","pmid":"https://pubmed.ncbi.nlm.nih.gov/25506787","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303335"},"language":"en","primary_location":{"id":"doi:10.1021/ac502629r","doi":"https://doi.org/10.1021/ac502629r","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ac502629r","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/ac502629r","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036552090","display_name":"Thillai V. Sekar","orcid":"https://orcid.org/0000-0002-2919-8802","observed_orcids":["https://orcid.org/0000-0002-2919-8802"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thillai V. Sekar","raw_affiliation_strings":["Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","Molecular Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine , 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Molecular Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine , 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091345173","display_name":"Kira Foygel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kira Foygel","raw_affiliation_strings":["Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","Molecular#R#Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine, 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Molecular#R#Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine, 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037658628","display_name":"Juri George Gelovani","orcid":"https://orcid.org/0000-0002-8413-6161","observed_orcids":["https://orcid.org/0000-0002-8413-6161"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juri G. Gelovani","raw_affiliation_strings":["Wayne State University , , 1400 Chrysler Freeway , , ,","Department#R#of Biomedical Engineering, College of Engineering, and Center for#R#Molecular Medicine and Genetics, School of Medicine, Wayne State University, 1400 Chrysler Freeway, Detroit, Michigan 48207, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wayne State University , , 1400 Chrysler Freeway , , ,","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department#R#of Biomedical Engineering, College of Engineering, and Center for#R#Molecular Medicine and Genetics, School of Medicine, Wayne State University, 1400 Chrysler Freeway, Detroit, Michigan 48207, United States","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018880989","display_name":"Ramasamy Paulmurugan","orcid":"https://orcid.org/0000-0001-7155-4738","observed_orcids":["https://orcid.org/0000-0001-7155-4738"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramasamy Paulmurugan","raw_affiliation_strings":["Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","Molecular#R#Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine, 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine , , 318 Campus Drive, East Wing, 1st Floor , , ,","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Molecular#R#Imaging Program at Stanford, Bio-X Program, Stanford University School of Medicine, 318 Campus Drive, East Wing, 1st Floor, Stanford, California 94305, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018880989"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.8197,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69040007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"87","issue":"2","first_page":"892","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.26589998602867126,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genetically-encoded-biosensors","display_name":"genetically encoded biosensors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/histone-methyltransferase-inhibitors","display_name":"histone methyltransferase inhibitors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.8700000047683716},{"id":"https://openalex.org/keywords/histone-demethylase-inhibitors","display_name":"histone demethylase inhibitors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/live-animal-imaging","display_name":"live animal imaging","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.7638837099075317},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.7474343776702881},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.6352651119232178},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6026281118392944},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5915220975875854},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.547967255115509},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5412125587463379},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.4986710548400879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45780158042907715},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.43653008341789246},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.35296630859375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35258832573890686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33247166872024536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.283821702003479},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20938646793365479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1063256561756134}],"mesh":[{"descriptor_ui":"D000076983","descriptor_name":"Histone Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ac502629r","doi":"https://doi.org/10.1021/ac502629r","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ac502629r","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4303335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anal Chem","raw_type":"Text"},{"id":"pmid:25506787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25506787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/ac502629r","doi":"https://doi.org/10.1021/ac502629r","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ac502629r","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1178628110","display_name":"Molecular Sensors for Imaging Histone Methylations in Living Animals","funder_award_id":"R01CA161091","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6985161458","display_name":null,"funder_award_id":"RO1 CA161091","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332427","display_name":"School of Medicine, Stanford University","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W160853306","https://openalex.org/W1509466986","https://openalex.org/W1967123371","https://openalex.org/W1973549360","https://openalex.org/W1973677698","https://openalex.org/W1977087749","https://openalex.org/W1992720699","https://openalex.org/W1994556689","https://openalex.org/W2009777487","https://openalex.org/W2009858080","https://openalex.org/W2012935454","https://openalex.org/W2013233429","https://openalex.org/W2016258157","https://openalex.org/W2019237526","https://openalex.org/W2021298125","https://openalex.org/W2031724786","https://openalex.org/W2040321376","https://openalex.org/W2041349016","https://openalex.org/W2041860345","https://openalex.org/W2048108896","https://openalex.org/W2052668971","https://openalex.org/W2054473817","https://openalex.org/W2055342414","https://openalex.org/W2060421066","https://openalex.org/W2064117044","https://openalex.org/W2084363318","https://openalex.org/W2085263653","https://openalex.org/W2091916973","https://openalex.org/W2095626300","https://openalex.org/W2096083625","https://openalex.org/W2096330673","https://openalex.org/W2104870341","https://openalex.org/W2106473601","https://openalex.org/W2107382027","https://openalex.org/W2110399580","https://openalex.org/W2121356384","https://openalex.org/W2123419812","https://openalex.org/W2131592995","https://openalex.org/W2144806790","https://openalex.org/W2158617484","https://openalex.org/W2163771097","https://openalex.org/W2164645872","https://openalex.org/W4252354555"],"related_works":["https://openalex.org/W2315590866","https://openalex.org/W2487985077","https://openalex.org/W4401336732","https://openalex.org/W2966154050","https://openalex.org/W4407408652","https://openalex.org/W2345107925","https://openalex.org/W4388010338","https://openalex.org/W4200246115","https://openalex.org/W2166672736","https://openalex.org/W4402630379"],"abstract_inverted_index":{"Post-translational":[0],"addition":[1],"of":[2,10,20,25,37,44,97,109,127,158,165,221,230,232],"methyl":[3],"groups":[4],"to":[5,60,175,196],"the":[6,23,86,128,148,163,186,198,213,228,236],"amino":[7],"terminal":[8],"tails":[9],"histone":[11,54,67,110,129,150,159,170,176,200,208,223],"proteins":[12],"regulates":[13],"cellular":[14,26],"gene":[15],"expression":[16],"at":[17,147],"various":[18],"stages":[19],"development":[21,43],"and":[22,62,93,102,122,139,144,189,194,217,226],"pathogenesis":[24],"diseases,":[27],"including":[28],"cancer.":[29],"Several":[30],"enzymes":[31],"that":[32,185],"modulate":[33],"these":[34,166],"post-translational":[35],"modifications":[36],"histones":[38],"are":[39,192],"promising":[40,52],"targets":[41],"for":[42,90],"small":[45,65,71],"molecule":[46,66],"drugs.":[47],"However,":[48],"there":[49],"is":[50],"no":[51],"real-time":[53],"methylation":[55,68,107,113,130,160,171,201,209],"detection":[56],"tool":[57],"currently":[58],"available":[59],"screen":[61],"validate":[63],"potential":[64,164],"modulators":[69],"in":[70,76,91,94,117,119,168,173,179,203,214,218],"animal":[72],"models.":[73],"With":[74],"this":[75],"mind,":[77],"we":[78],"developed":[79,187],"genetically":[80],"encoded":[81],"molecular":[82],"biosensors":[83],"based":[84],"on":[85],"split-enzyme":[87],"complementation":[88],"approach":[89],"vitro":[92,118,215],"vivo":[95,219],"imaging":[96,157],"lysine":[98,103],"9":[99],"(H3-K9":[100],"sensor)":[101,106],"27":[104],"(H3-K27":[105],"marks":[108],"3.":[111],"These":[112,206],"sensors":[114,161,167,191,210],"were":[115],"validated":[116],"HEK293T,":[120],"HepG2,":[121],"HeLa":[123],"cells.":[124],"The":[125],"efficiency":[126],"sensor":[131],"was":[132],"assessed":[133],"by":[134],"employing":[135],"methyltransferase":[136,177,224],"inhibitors":[137,178,225],"(Bix01294":[138],"UNC0638),":[140],"demethylase":[141],"inhibitor":[142],"(JIB-04),":[143],"siRNA":[145],"silencing":[146],"endogenous":[149],"K9-methyltransferase":[151],"enzyme":[152],"level.":[153],"Furthermore,":[154],"noninvasive":[155],"bioluminescence":[156],"confirmed":[162,184],"monitoring":[169],"status":[172],"response":[174],"living":[180,204],"animals.":[181,205],"Experimental":[182],"results":[183],"H3-K9":[188],"H3-K27":[190],"specific":[193],"sensitive":[195],"image":[197],"drug-induced":[199],"changes":[202],"novel":[207],"can":[211],"facilitate":[212],"screening":[216],"characterization":[220],"new":[222],"accelerate":[227],"pace":[229],"introduction":[231],"epigenetic":[233],"therapies":[234],"into":[235],"clinic.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}