{"id":"https://openalex.org/W1969758477","doi":"https://doi.org/10.1089/ten.2006.12.1227","title":"A Novel Approach to Regenerating Periodontal Tissue by Grafting Autologous Cultured Periosteum","display_name":"A Novel Approach to Regenerating Periodontal Tissue by Grafting Autologous Cultured Periosteum","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W1969758477","doi":"https://doi.org/10.1089/ten.2006.12.1227","mag":"1969758477","pmid":"https://pubmed.ncbi.nlm.nih.gov/16771636"},"language":"en","primary_location":{"id":"doi:10.1089/ten.2006.12.1227","doi":"https://doi.org/10.1089/ten.2006.12.1227","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.2006.12.1227","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113828060","display_name":"Hirokazu Mizuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Mizuno","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109251929","display_name":"Ken\u2010ichiro Hata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-Ichiro Hata","raw_affiliation_strings":["Genetic and Regenerative Medical Center, Nagoya University Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic and Regenerative Medical Center, Nagoya University Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210090647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111352885","display_name":"Koji Kojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Kojima","raw_affiliation_strings":["Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087621922","display_name":"Lawrence J. Bonassar","orcid":"https://orcid.org/0000-0003-1094-6433","observed_orcids":["https://orcid.org/0000-0003-1094-6433"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence J. Bonassar","raw_affiliation_strings":["Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075216520","display_name":"Charles A. Vacanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Vacanti","raw_affiliation_strings":["Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076974173","display_name":"Minoru Ueda","orcid":"https://orcid.org/0000-0002-2305-3303","observed_orcids":["https://orcid.org/0000-0002-2305-3303"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Ueda","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4608,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.95969687,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"5","first_page":"1227","last_page":"1335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontal-regeneration","display_name":"periodontal regeneration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/alveolar-bone-regeneration","display_name":"alveolar bone regeneration","score":0.8349999785423279},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/furcation-defects","display_name":"furcation defects","score":0.953000009059906},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.6779999732971191},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.9618434309959412},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.6455832719802856},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.563968300819397},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4970147907733917},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4871484935283661},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4859972894191742},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.47865045070648193},{"id":"https://openalex.org/C2776337968","wikidata":"https://www.wikidata.org/wiki/Q3814234","display_name":"Bone grafting","level":2,"score":0.47064679861068726},{"id":"https://openalex.org/C2775937945","wikidata":"https://www.wikidata.org/wiki/Q222958","display_name":"Grafting","level":3,"score":0.4336022436618805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3735477328300476},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3493257164955139},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32659876346588135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32655662298202515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3145757019519806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1972959339618683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11975669860839844},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001641","descriptor_name":"Bicuspid","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D001641","descriptor_name":"Bicuspid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008334","descriptor_name":"Mandible","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D008334","descriptor_name":"Mandible","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010510","descriptor_name":"Periodontal Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010519","descriptor_name":"Periodontium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010519","descriptor_name":"Periodontium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010521","descriptor_name":"Periosteum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010521","descriptor_name":"Periosteum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/ten.2006.12.1227","doi":"https://doi.org/10.1089/ten.2006.12.1227","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.2006.12.1227","pdf_url":null,"source":{"id":"https://openalex.org/S164177214","display_name":"Tissue Engineering","issn_l":"1076-3279","issn":["1076-3279","1557-8690"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering","raw_type":"journal-article"},{"id":"pmid:16771636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16771636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W122560788","https://openalex.org/W1559702139","https://openalex.org/W1574631190","https://openalex.org/W1974690659","https://openalex.org/W1974790802","https://openalex.org/W1977779461","https://openalex.org/W1984079324","https://openalex.org/W1985526797","https://openalex.org/W1986339409","https://openalex.org/W2005154421","https://openalex.org/W2010777478","https://openalex.org/W2012816425","https://openalex.org/W2016161594","https://openalex.org/W2029119521","https://openalex.org/W2033973987","https://openalex.org/W2035817691","https://openalex.org/W2042133699","https://openalex.org/W2050455488","https://openalex.org/W2059485125","https://openalex.org/W2062224667","https://openalex.org/W2063872833","https://openalex.org/W2065183689","https://openalex.org/W2067555639","https://openalex.org/W2077648724","https://openalex.org/W2080249007","https://openalex.org/W2081438193","https://openalex.org/W2094560262","https://openalex.org/W2102481660","https://openalex.org/W2117171195","https://openalex.org/W2131705125","https://openalex.org/W2137636591","https://openalex.org/W2143569485","https://openalex.org/W2158210173","https://openalex.org/W2292948463","https://openalex.org/W2412695795","https://openalex.org/W2467019647","https://openalex.org/W4252554754"],"related_works":["https://openalex.org/W260041763","https://openalex.org/W2334059352","https://openalex.org/W2354582889","https://openalex.org/W2417958439","https://openalex.org/W1550099735","https://openalex.org/W2388072072","https://openalex.org/W35495651","https://openalex.org/W2378013768","https://openalex.org/W2051789537","https://openalex.org/W2988556683"],"abstract_inverted_index":{"In":[0,30,126],"the":[1,27,48,68,110,117,130,144,146,163],"field":[2],"of":[3,23,71,128,165],"oral":[4],"and":[5,75,99,121,124,135],"maxillofacial":[6],"surgery,":[7],"tissue-engineering":[8],"techniques":[9],"have":[10],"been":[11],"found":[12],"useful":[13],"in":[14,109,143,158],"regenerating":[15,159],"lost":[16],"tissues.":[17],"Periodontal":[18],"disease":[19],"causes":[20],"severe":[21],"destruction":[22],"periodontal":[24,38,166],"tissue,":[25,141],"including":[26],"alveolar":[28,160],"bone.":[29],"this":[31],"study":[32],"we":[33],"attempted":[34],"to":[35,60,86],"regenerate":[36],"canine":[37],"tissue":[39],"defects":[40,132,147],"by":[41],"grafting":[42],"autologous":[43],"cultured":[44,77,94],"membrane":[45],"derived":[46],"from":[47,67],"periosteum.":[49],"Under":[50],"appropriate":[51],"culture":[52],"conditions,":[53],"periosteal":[54],"cells":[55,79],"produce":[56],"enough":[57],"extracellular":[58],"matrix":[59],"form":[61],"sheets.":[62],"Periosteum":[63],"specimens":[64],"were":[65,76,119,133],"peeled":[66],"mandibular":[69,112],"body":[70],"adult":[72],"hybrid":[73],"dogs":[74],"until":[78],"formed":[80,139],"membrane.":[81],"ALP":[82],"activity":[83],"was":[84,97],"measured":[85],"determine":[87],"an":[88],"optimal":[89],"time":[90],"for":[91,162],"grafting.":[92],"The":[93],"periosteum":[95],"(CP)":[96],"grafted":[98],"sutured":[100],"on":[101],"a":[102],"mechanically":[103],"made":[104],"Class":[105],"III":[106],"furcation":[107],"defect":[108],"4th":[111],"premolars.":[113],"After":[114],"3":[115],"months,":[116],"samples":[118],"harvested":[120],"observed":[122],"radiologically":[123],"histologically.":[125],"cases":[127],"CP,":[129],"bone":[131,161],"regenerated":[134],"filled":[136],"with":[137],"newly":[138],"hard":[140],"whereas":[142],"controls":[145],"remained.":[148],"These":[149],"results":[150],"show":[151],"that":[152],"our":[153],"novel":[154],"treatment":[155,164],"is":[156],"effective":[157],"disease.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
