{"id":"https://openalex.org/W1969680643","doi":"https://doi.org/10.1016/j.bbrc.2006.08.039","title":"Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation","display_name":"Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation","publication_year":2006,"publication_date":"2006-08-18","ids":{"openalex":"https://openalex.org/W1969680643","doi":"https://doi.org/10.1016/j.bbrc.2006.08.039","mag":"1969680643","pmid":"https://pubmed.ncbi.nlm.nih.gov/16934220"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.08.039","doi":"https://doi.org/10.1016/j.bbrc.2006.08.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.08.039","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016407820","display_name":"Alfredo Pezzicoli","orcid":"https://orcid.org/0009-0000-3400-8949","observed_orcids":["https://orcid.org/0009-0000-3400-8949"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfredo Pezzicoli","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030302760","display_name":"Cristina Ulivieri","orcid":"https://orcid.org/0000-0002-1710-7977","observed_orcids":["https://orcid.org/0000-0002-1710-7977"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Ulivieri","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001912554","display_name":"Nagaja Capitani","orcid":"https://orcid.org/0000-0003-3653-8972","observed_orcids":["https://orcid.org/0000-0003-3653-8972"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nagaja Capitani","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033666678","display_name":"Andrea Ventura","orcid":"https://orcid.org/0000-0003-4320-9907","observed_orcids":["https://orcid.org/0000-0003-4320-9907"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Ventura","raw_affiliation_strings":["Department of Molecular Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057101865","display_name":"Pier Giuseppe Pelicci","orcid":"https://orcid.org/0000-0002-5076-2316","observed_orcids":["https://orcid.org/0000-0002-5076-2316"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piergiuseppe Pelicci","raw_affiliation_strings":["Department of Molecular Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011115538","display_name":"Cosima T. Baldari","orcid":"https://orcid.org/0000-0002-4414-6744","observed_orcids":["https://orcid.org/0000-0002-4414-6744"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cosima T. Baldari","raw_affiliation_strings":["Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011115538"],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.3368,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.49435278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"349","issue":"1","first_page":"322","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p66shc","display_name":"p66Shc","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/promoter-demethylation","display_name":"promoter demethylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/oxidative-stress-induced-apoptosis","display_name":"oxidative stress-induced apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.7620000243186951},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nondividing-cells","display_name":"non-dividing cells","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7518293857574463},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.74821937084198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6584736704826355},{"id":"https://openalex.org/C16824249","wikidata":"https://www.wikidata.org/wiki/Q5205753","display_name":"DNA demethylation","level":5,"score":0.6380401253700256},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.6183934211730957},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6148712635040283},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6083362102508545},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.528926432132721},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5196536779403687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5136780142784119},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49947047233581543},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4734480082988739},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4442654848098755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22010695934295654}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrc.2006.08.039","doi":"https://doi.org/10.1016/j.bbrc.2006.08.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.08.039","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:16934220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16934220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/21870","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/21870","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1605104953","https://openalex.org/W1669304052","https://openalex.org/W1968263601","https://openalex.org/W1985191673","https://openalex.org/W1988290255","https://openalex.org/W2004048966","https://openalex.org/W2008874842","https://openalex.org/W2011405307","https://openalex.org/W2023973783","https://openalex.org/W2053968155","https://openalex.org/W2062566852","https://openalex.org/W2064625809","https://openalex.org/W2067132184","https://openalex.org/W2069785923","https://openalex.org/W2074140050","https://openalex.org/W2083663211","https://openalex.org/W2138574897","https://openalex.org/W2150381945","https://openalex.org/W2155678845","https://openalex.org/W2165209574","https://openalex.org/W2183836380","https://openalex.org/W2312454132","https://openalex.org/W2574763986","https://openalex.org/W6663999286"],"related_works":["https://openalex.org/W2062566852","https://openalex.org/W2138574897","https://openalex.org/W2053968155","https://openalex.org/W2105830428","https://openalex.org/W2149616263","https://openalex.org/W2095142030","https://openalex.org/W4200555762","https://openalex.org/W2155452770","https://openalex.org/W7099387097","https://openalex.org/W2143354474"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}