{"id":"https://openalex.org/W1969587778","doi":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","title":"Intraventricular concentration times time (C \ufffd T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma","display_name":"Intraventricular concentration times time (C \ufffd T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma","publication_year":1999,"publication_date":"1999-01-15","ids":{"openalex":"https://openalex.org/W1969587778","doi":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","mag":"1969587778","pmid":"https://pubmed.ncbi.nlm.nih.gov/10023723"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","doi":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990115%2985%3A2%3C511%3A%3AAID-CNCR33%3E3.0.CO%3B2-H","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990115%2985%3A2%3C511%3A%3AAID-CNCR33%3E3.0.CO%3B2-H","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113696813","display_name":"Asher Moshe Moser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asher M. Moser","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA","Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066484657","display_name":"Peter C. Adamson","orcid":"https://orcid.org/0000-0002-9487-757X","observed_orcids":["https://orcid.org/0000-0002-9487-757X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Adamson","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrea J. Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea J. Gillespie","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111496887","display_name":"DG Poplack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Poplack","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank M. Balis","raw_affiliation_strings":["Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024249524"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.1864,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.793252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"85","issue":"2","first_page":"511","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraventricular-chemotherapy","display_name":"intraventricular chemotherapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":1.0},{"id":"https://openalex.org/keywords/meningeal-lymphoma","display_name":"meningeal lymphoma","score":0.847000002861023},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7440000176429749},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.7229999899864197},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9237766265869141},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.8376045227050781},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7775992155075073},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5920326113700867},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5464710593223572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4234333634376526},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40423548221588135},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3581840395927429}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","doi":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990115%2985%3A2%3C511%3A%3AAID-CNCR33%3E3.0.CO%3B2-H","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:10023723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10023723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","doi":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819990115%2985%3A2%3C511%3A%3AAID-CNCR33%3E3.0.CO%3B2-H","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1969587778.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W176021971","https://openalex.org/W1589458972","https://openalex.org/W1606856073","https://openalex.org/W1795993802","https://openalex.org/W1916709153","https://openalex.org/W1976630219","https://openalex.org/W1997668938","https://openalex.org/W2001973410","https://openalex.org/W2004622874","https://openalex.org/W2033600000","https://openalex.org/W2049194757","https://openalex.org/W2058326606","https://openalex.org/W2093772637","https://openalex.org/W2149090375","https://openalex.org/W2172671442","https://openalex.org/W2244173686","https://openalex.org/W2342032414","https://openalex.org/W2466382613","https://openalex.org/W3021422704","https://openalex.org/W4324114382"],"related_works":["https://openalex.org/W2149090375","https://openalex.org/W2149558826","https://openalex.org/W176021971","https://openalex.org/W2244173686","https://openalex.org/W2056655605","https://openalex.org/W2022417746","https://openalex.org/W1481098920","https://openalex.org/W1819450960","https://openalex.org/W1830321071","https://openalex.org/W1916709153"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intraventricular":[1],"chemotherapy":[2,35],"results":[3],"in":[4,182,214,251],"more":[5,16],"uniform":[6],"drug":[7,18],"distribution":[8],"within":[9],"the":[10,241],"subarachnoid":[11],"space":[12],"and":[13,41,81,90,146,213,220,249,256,265,282,292],"allows":[14],"for":[15,37,55,109,115,136,176,218,286],"flexible":[17],"administration":[19],"schedules.":[20],"The":[21],"authors":[22],"report":[23],"their":[24],"experience":[25],"with":[26,122,240,260,288],"an":[27,280],"intraventricular":[28,105,127],"concentration":[29],"times":[30],"time":[31],"(C":[32],"x":[33,52,96,160,234,243],"T)":[34],"regimen":[36,276],"recurrent":[38,201,289],"meningeal":[39,56,227,290],"leukemia":[40,59,70,291],"lymphoma.":[42,293],"METHODS:":[43],"Twenty-one":[44],"patients":[45,169,198,208,287],"(median":[46],"age,":[47],"11.6":[48],"years)":[49],"received":[50,246],"C":[51,95,159,233,242],"T":[53,97,161,235,244],"therapy":[54,75,99,152,236],"acute":[57],"lymphoblastic":[58],"(n":[60,65,71],"=":[61,66,72],"18),":[62],"Burkitt's":[63],"lymphoma":[64],"2),":[67],"or":[68,84,131,163,203],"undifferentiated":[69],"1).":[73],"Prior":[74],"included":[76],"standard":[77],"intrathecal":[78],"(IT)":[79],"methotrexate":[80,106,132,145,162],"cytarabine,":[82],"cranial":[83],"craniospinal":[85,247],"radiation":[86],"(median,":[87],"24":[88,230],"Gy),":[89],"0-5":[91],"experimental":[92],"treatment":[93,285],"modalities.":[94],"induction":[98],"consisted":[100,153],"of":[101,104,125,144,149,154,158,168,171,185,200],"2":[102,140,147,207],"mg":[103],"administered":[107],"daily":[108,135],"3":[110,137,257],"days":[111,138,187],"every":[112,139],"10":[113,186],"days,":[114],"4":[116,123],"courses.":[117],"Patients":[118],"were":[119,174],"then":[120],"consolidated":[121],"courses":[124,143,148,157],"alternating":[126,155],"cytarabine":[128],"(15":[129],"mg/day)":[130,134],"(2":[133,142],"weeks":[141],"cytarabine).":[150],"Maintenance":[151],"monthly":[156],"cytarabine.":[164],"RESULTS:":[165],"Ninety-three":[166],"percent":[167],"(14":[170],"15)":[172],"who":[173],"evaluable":[175],"response":[177],"achieved":[178],"a":[179,183,226],"complete":[180,216],"remission":[181,192,217,252],"median":[184],"(range,":[188],"2-40":[189],"days).":[190],"Median":[191],"duration":[193],"was":[194,238,270],"15":[195],"months.":[196,267],"Fourteen":[197],"died":[199],"disease":[202,261],"systemic":[204],"treatment-related":[205],"complications;":[206],"are":[209,258],"alive,":[210],"off":[211],"treatment,":[212],"continuous":[215],"59+":[219],"89+":[221],"months;":[222,255],"1":[223],"patient":[224,269],"experienced":[225],"relapse":[228],"at":[229,253,262],"months":[231],"on":[232],"but":[237],"reinduced":[239],"regimen,":[245],"radiation,":[248],"is":[250],"142+":[254],"alive":[259],"32+,":[263],"72+,":[264],"81+":[266],"One":[268],"lost":[271],"to":[272,278],"follow-up.":[273],"CONCLUSIONS:":[274],"This":[275],"appears":[277],"be":[279],"effective":[281],"well-tolerated":[283],"palliative":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}