{"id":"https://openalex.org/W1969459151","doi":"https://doi.org/10.1897/ieam_2009-069.1","title":"The chironomid acute toxicity test: Development of a new test system","display_name":"The chironomid acute toxicity test: Development of a new test system","publication_year":2009,"publication_date":"2009-11-03","ids":{"openalex":"https://openalex.org/W1969459151","doi":"https://doi.org/10.1897/ieam_2009-069.1","mag":"1969459151","pmid":"https://pubmed.ncbi.nlm.nih.gov/19886732"},"language":"en","primary_location":{"id":"doi:10.1897/ieam_2009-069.1","doi":"https://doi.org/10.1897/ieam_2009-069.1","is_oa":true,"landing_page_url":"https://doi.org/10.1897/ieam_2009-069.1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1897/IEAM_2009-069.1","source":{"id":"https://openalex.org/S112294809","display_name":"Integrated Environmental Assessment and Management","issn_l":"1551-3777","issn":["1551-3777","1551-3793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrated Environmental Assessment and Management","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1897/IEAM_2009-069.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031259064","display_name":"Lennart Weltje","orcid":"https://orcid.org/0000-0002-5191-4158","observed_orcids":["https://orcid.org/0000-0002-5191-4158"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lennart Weltje","raw_affiliation_strings":["BASF SE, Crop Protection\u2014Ecotoxicology, Speyerer Strasse 2, D-67117 Limburgerhof, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, Crop Protection\u2014Ecotoxicology, Speyerer Strasse 2, D-67117 Limburgerhof, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019545026","display_name":"Hans Rufli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Rufli","raw_affiliation_strings":["ecotoxsolutions, Schwarzwaldallee 215, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ecotoxsolutions, Schwarzwaldallee 215, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050950926","display_name":"Fred Heimbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fred Heimbach","raw_affiliation_strings":["Bayer CropScience AG, Department of Ecotoxicology, Monheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer CropScience AG, Department of Ecotoxicology, Monheim, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006263608","display_name":"James R. Wheeler","orcid":"https://orcid.org/0000-0002-9162-5035","observed_orcids":["https://orcid.org/0000-0002-9162-5035"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Wheeler","raw_affiliation_strings":["Syngenta Environmental Safety, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Environmental Safety, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023233925","display_name":"Marco Vervliet\u2010Scheebaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Vervliet-Scheebaum","raw_affiliation_strings":["University of Freiburg, Faculty of Biology, Plant Biotechnology, Sch\u00e4nzlestrasse 1, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Freiburg, Faculty of Biology, Plant Biotechnology, Sch\u00e4nzlestrasse 1, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113859936","display_name":"Michael J. Hamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Hamer","raw_affiliation_strings":["Syngenta Environmental Safety, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Environmental Safety, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031259064"],"corresponding_institution_ids":["https://openalex.org/I4210107087"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.0821,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.72769329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"2","first_page":"301","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13092","display_name":"Environmental Chemistry and Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chironomus","display_name":"Chironomus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/first-instar-larvae","display_name":"first instar larvae","score":0.9660000205039978},{"id":"https://openalex.org/keywords/aquatic-invertebrates","display_name":"aquatic invertebrates","score":0.6819999814033508},{"id":"https://openalex.org/keywords/insecticides","display_name":"insecticides","score":0.5559999942779541},{"id":"https://openalex.org/keywords/non-target-organisms","display_name":"non-target organisms","score":0.656000018119812},{"id":"https://openalex.org/keywords/oecd-test-guidelines","display_name":"OECD test guidelines","score":0.6420000195503235},{"id":"https://openalex.org/keywords/regulatory-testing","display_name":"regulatory testing","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C13474642","wikidata":"https://www.wikidata.org/wiki/Q43806","display_name":"Invertebrate","level":2,"score":0.6577868461608887},{"id":"https://openalex.org/C2776296159","wikidata":"https://www.wikidata.org/wiki/Q2704714","display_name":"Chironomus","level":4,"score":0.5742558240890503},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.45595717430114746},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.4499253034591675},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4490722119808197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4448191225528717},{"id":"https://openalex.org/C2780158794","wikidata":"https://www.wikidata.org/wiki/Q672531","display_name":"Daphnia magna","level":3,"score":0.42865562438964844},{"id":"https://openalex.org/C2778706068","wikidata":"https://www.wikidata.org/wiki/Q228145","display_name":"Chironomidae","level":3,"score":0.31501901149749756},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.29291874170303345},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2781010866165161},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.161378413438797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10825428366661072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05397942662239075},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001556","descriptor_name":"Hexachlorocyclohexane","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002733","descriptor_name":"Chlorophenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D038622","descriptor_name":"Internationality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1897/ieam_2009-069.1","doi":"https://doi.org/10.1897/ieam_2009-069.1","is_oa":true,"landing_page_url":"https://doi.org/10.1897/ieam_2009-069.1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1897/IEAM_2009-069.1","source":{"id":"https://openalex.org/S112294809","display_name":"Integrated Environmental Assessment and Management","issn_l":"1551-3777","issn":["1551-3777","1551-3793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrated Environmental Assessment and Management","raw_type":"journal-article"},{"id":"pmid:19886732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19886732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrated environmental assessment and management","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1897/ieam_2009-069.1","doi":"https://doi.org/10.1897/ieam_2009-069.1","is_oa":true,"landing_page_url":"https://doi.org/10.1897/ieam_2009-069.1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1897/IEAM_2009-069.1","source":{"id":"https://openalex.org/S112294809","display_name":"Integrated Environmental Assessment and Management","issn_l":"1551-3777","issn":["1551-3777","1551-3793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrated Environmental Assessment and Management","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329921","display_name":"European Crop Protection Association","ror":null},{"id":"https://openalex.org/F4320332735","display_name":"Bayer CropScience","ror":"https://ror.org/04hmn8g73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969459151.pdf","grobid_xml":"https://content.openalex.org/works/W1969459151.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W63688871","https://openalex.org/W142638454","https://openalex.org/W1548974926","https://openalex.org/W1976018111","https://openalex.org/W1984735443","https://openalex.org/W1990001453","https://openalex.org/W1991536033","https://openalex.org/W1999138280","https://openalex.org/W2002989106","https://openalex.org/W2018322231","https://openalex.org/W2036531290","https://openalex.org/W2046926121","https://openalex.org/W2060547799","https://openalex.org/W2135160102","https://openalex.org/W2150335579","https://openalex.org/W2167036226","https://openalex.org/W2186826906","https://openalex.org/W2290195878","https://openalex.org/W2313441666","https://openalex.org/W2426949606","https://openalex.org/W2498129669","https://openalex.org/W2507337907","https://openalex.org/W3202117370"],"related_works":["https://openalex.org/W2121039883","https://openalex.org/W4254428496","https://openalex.org/W2357887502","https://openalex.org/W2160425678","https://openalex.org/W2046926121","https://openalex.org/W4233131215","https://openalex.org/W4231257322","https://openalex.org/W2989996179","https://openalex.org/W7160921015","https://openalex.org/W1990001453"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"the":[3,21,26,33,40,47,59,90],"basis":[4],"for":[5,25,78,81,137],"a":[6,99,114,131],"water-only":[7],"acute":[8,27],"chironomid":[9],"toxicity":[10],"test":[11,23,31,42,107,115,122],"guideline":[12,54],"using":[13],"first-instar":[14],"larvae.":[15],"The":[16],"method":[17],"is":[18,56,98,128],"based":[19],"on":[20],"OECD":[22],"guidelines":[24],"Daphnia":[28,83],"sp.":[29,84,97,127],"immobilization":[30],"and":[32,120],"long-term":[34],"tests":[35],"with":[36,117],"Chironomus":[37,96,126],"sp.,":[38],"reflecting":[39],"common":[41],"procedures":[43],"currently":[44,102],"used":[45,103],"by":[46],"European":[48,60],"agrochemical":[49],"industry.":[50],"Development":[51],"of":[52,89,92],"this":[53],"proposal":[55],"important":[57],"under":[58,66],"Plant":[61],"Protection":[62],"Products":[63],"Directive":[64],"(91/414/EEC),":[65],"which":[67,82],"an":[68],"insect":[69,101],"species":[70,136],"may":[71,85],"be":[72,75,87],"required":[73],"to":[74],"tested,":[76],"particularly":[77],"certain":[79,121],"insecticides,":[80],"not":[86],"representative":[88],"sensitivity":[91],"nontarget":[93],"aquatic":[94],"invertebrates.":[95],"freshwater":[100,134],"in":[104],"different":[105],"international":[106],"guidelines.":[108],"Because":[109],"their":[110],"ready":[111],"availability":[112],"as":[113,130],"organism,":[116],"culturing":[118],"conditions":[119],"methods":[123],"already":[124],"established,":[125],"regarded":[129],"suitable":[132],"additional":[133],"invertebrate":[135],"regulatory":[138],"testing.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}