{"id":"https://openalex.org/W1969428124","doi":"https://doi.org/10.1124/mol.104.002824","title":"Protein Thiol Modification by 15-deoxy-\u039412,14-Prostaglandin J2 Addition in Mesangial Cells: Role in the Inhibition of Pro-inflammatory Genes","display_name":"Protein Thiol Modification by 15-deoxy-\u039412,14-Prostaglandin J2 Addition in Mesangial Cells: Role in the Inhibition of Pro-inflammatory Genes","publication_year":2004,"publication_date":"2004-08-19","ids":{"openalex":"https://openalex.org/W1969428124","doi":"https://doi.org/10.1124/mol.104.002824","mag":"1969428124","pmid":"https://pubmed.ncbi.nlm.nih.gov/15317873"},"language":"en","primary_location":{"id":"doi:10.1124/mol.104.002824","doi":"https://doi.org/10.1124/mol.104.002824","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.104.002824","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10261/99222","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033607099","display_name":"Francisco J. S\u00e1nchez-G\u00f3mez","orcid":"https://orcid.org/0000-0002-0336-9327","observed_orcids":["https://orcid.org/0000-0002-0336-9327"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J S\u00e1nchez-G\u00f3mez","raw_affiliation_strings":["Departamento de Estructura y Funci\u00f3n de Prote\u00ednas, Centro de Investigaciones Biol\u00f3gicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain","Departamento de Estructura y Funci\u00f3n de Prote\u00ednas, Centro de Investigaciones Biol\u00f3gicas, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Estructura y Funci\u00f3n de Prote\u00ednas, Centro de Investigaciones Biol\u00f3gicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]},{"raw_affiliation_string":"Departamento de Estructura y Funci\u00f3n de Prote\u00ednas, Centro de Investigaciones Biol\u00f3gicas, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109273857","display_name":"Eva Cernuda\u2010Moroll\u00f3n","orcid":"https://orcid.org/0000-0002-6561-819X","observed_orcids":["https://orcid.org/0000-0002-6561-819X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Cernuda-Moroll\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085300028","display_name":"Konstantinos Stamatakis","orcid":"https://orcid.org/0000-0001-9934-3502","observed_orcids":["https://orcid.org/0000-0001-9934-3502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Stamatakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089947239","display_name":"Dolores P\u00e9rez\u2010Sala","orcid":"https://orcid.org/0000-0003-0600-665X","observed_orcids":["https://orcid.org/0000-0003-0600-665X"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Dolores P\u00e9rez-Sala","raw_affiliation_strings":["Spanish National Research Council"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spanish National Research Council","institution_ids":["https://openalex.org/I134820265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":4.3313,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.94036092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"5","first_page":"1349","last_page":"1358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.28929999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/15-deoxy-delta12-14-prostaglandin-j2","display_name":"15-deoxy-\u039412,14-prostaglandin J2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cyclopentenone-prostaglandins","display_name":"cyclopentenone prostaglandins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-thiol-modification","display_name":"protein thiol modification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mesangial-cells","display_name":"mesangial cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.6209999918937683},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.984000027179718},{"id":"https://openalex.org/keywords/gw9662","display_name":"GW9662","score":0.753000020980835},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alpha-beta-unsaturated-carbonyl-compounds","display_name":"\u03b1,\u03b2-unsaturated carbonyl compounds","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.6210393905639648},{"id":"https://openalex.org/C2777903533","wikidata":"https://www.wikidata.org/wiki/Q2292678","display_name":"Cyclopentenone","level":2,"score":0.58830326795578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5518829226493835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3997640609741211},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.23069003224372864}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005920","descriptor_name":"Glomerular Mesangium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005920","descriptor_name":"Glomerular Mesangium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1124/mol.104.002824","doi":"https://doi.org/10.1124/mol.104.002824","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.104.002824","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:15317873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15317873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/99222","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/99222","pdf_url":"http://hdl.handle.net/10261/99222","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:2182148810","doi":null,"is_oa":false,"landing_page_url":"https://molpharm.aspetjournals.org/content/early/2004/08/18/mol.104.002824.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.csic.es:10261/99222","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/99222","pdf_url":"http://hdl.handle.net/10261/99222","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969428124.pdf","grobid_xml":"https://content.openalex.org/works/W1969428124.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W12424231","https://openalex.org/W1539392991","https://openalex.org/W1582022233","https://openalex.org/W1633340712","https://openalex.org/W1812573520","https://openalex.org/W1852647106","https://openalex.org/W1977554203","https://openalex.org/W1978250188","https://openalex.org/W1979201752","https://openalex.org/W1981402689","https://openalex.org/W1989121880","https://openalex.org/W1992724479","https://openalex.org/W1996267589","https://openalex.org/W1999894132","https://openalex.org/W2005674716","https://openalex.org/W2012677944","https://openalex.org/W2025420553","https://openalex.org/W2048527249","https://openalex.org/W2051057294","https://openalex.org/W2051540000","https://openalex.org/W2053522439","https://openalex.org/W2056073338","https://openalex.org/W2058218787","https://openalex.org/W2062931867","https://openalex.org/W2064208521","https://openalex.org/W2077417063","https://openalex.org/W2089977895","https://openalex.org/W2093352910","https://openalex.org/W2100677911","https://openalex.org/W2100829376","https://openalex.org/W2101460040","https://openalex.org/W2113971187","https://openalex.org/W2123055462","https://openalex.org/W2134745341","https://openalex.org/W2148069738","https://openalex.org/W2161908800","https://openalex.org/W2168051361","https://openalex.org/W2171274653","https://openalex.org/W2312069492","https://openalex.org/W2417698815","https://openalex.org/W4240789623","https://openalex.org/W4285719527","https://openalex.org/W6716845534"],"related_works":["https://openalex.org/W2131050015","https://openalex.org/W1966299493","https://openalex.org/W2091704534","https://openalex.org/W2083425883","https://openalex.org/W2064208521","https://openalex.org/W2546406187","https://openalex.org/W2070716938","https://openalex.org/W1492228142","https://openalex.org/W2053466480","https://openalex.org/W1989121880"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
