{"id":"https://openalex.org/W1969268573","doi":"https://doi.org/10.1159/000118311","title":"Spontaneous and Drug-Induced Locomotor Activity after Partial Dopamine Denervation of the Ventral Striatum","display_name":"Spontaneous and Drug-Induced Locomotor Activity after Partial Dopamine Denervation of the Ventral Striatum","publication_year":2008,"publication_date":"2008-02-20","ids":{"openalex":"https://openalex.org/W1969268573","doi":"https://doi.org/10.1159/000118311","mag":"1969268573","pmid":"https://pubmed.ncbi.nlm.nih.gov/3587570"},"language":"en","primary_location":{"id":"doi:10.1159/000118311","doi":"https://doi.org/10.1159/000118311","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000118311","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105351777","display_name":"Robert J. Carey","orcid":"https://orcid.org/0000-0003-4566-1438","observed_orcids":["https://orcid.org/0000-0003-4566-1438"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4210114695","display_name":"Syracuse VA Medical Center","ror":"https://ror.org/0332k3m42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210114695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.J. Carey","raw_affiliation_strings":["Veterans Administration Medical Center and State University of New York, Upstate Medical Center, Syracuse, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration Medical Center and State University of New York, Upstate Medical Center, Syracuse, N.Y., USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I20388574","https://openalex.org/I4210114695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057186547","display_name":"Rainer K.W. Schwarting","orcid":"https://orcid.org/0000-0002-4686-3974","observed_orcids":["https://orcid.org/0000-0002-4686-3974"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Schwarting","raw_affiliation_strings":["Institute of Psychology III, University of D\u00fcsseldorf, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychology III, University of D\u00fcsseldorf, FRG","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.377,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.53548531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"16","issue":"2-3","first_page":"121","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventral-striatum","display_name":"ventral striatum","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/spontaneous-locomotor-activity","display_name":"spontaneous motor activity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amphetamine-response","display_name":"amphetamine response","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dopamine-reuptake","display_name":"dopamine reuptake","score":0.43799999356269836},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.5759999752044678},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.4300000071525574},{"id":"https://openalex.org/keywords/dopamine-d4-receptor","display_name":"dopamine D4 receptor","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dopamine-d5-receptor","display_name":"dopamine D5 receptor","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.9019665718078613},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.8306520581245422},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8257142305374146},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.793221116065979},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6320115923881531},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.625799298286438},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.6112707257270813},{"id":"https://openalex.org/C2777288102","wikidata":"https://www.wikidata.org/wiki/Q780181","display_name":"Oxidopamine","level":5,"score":0.5348044633865356},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5184819102287292},{"id":"https://openalex.org/C2993436365","wikidata":"https://www.wikidata.org/wiki/Q925958","display_name":"Locomotor activity","level":2,"score":0.5070273876190186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5037266612052917},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5030037760734558},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.47828540205955505},{"id":"https://openalex.org/C2776145449","wikidata":"https://www.wikidata.org/wiki/Q1706418","display_name":"Dextroamphetamine","level":4,"score":0.4600835144519806},{"id":"https://openalex.org/C2776743251","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Ventral striatum","level":4,"score":0.45734286308288574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39802250266075134},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34749236702919006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23553931713104248},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.10172829031944275},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0648622214794159}],"mesh":[{"descriptor_ui":"D000662","descriptor_name":"Amphetamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000118311","doi":"https://doi.org/10.1159/000118311","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000118311","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},{"id":"pmid:3587570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3587570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G419662242","display_name":"BEHAVIORAL ANALYSIS OF BRAIN CATECHOLAMINE DEFICITS","funder_award_id":"R01MH033959","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030082138","https://openalex.org/W2441132927","https://openalex.org/W2081234897","https://openalex.org/W68582358","https://openalex.org/W2023612551","https://openalex.org/W2085734371","https://openalex.org/W2072309959","https://openalex.org/W283816631","https://openalex.org/W4414282686","https://openalex.org/W2045852656"],"abstract_inverted_index":{"Spontaneous":[0],"and":[1,52,73,85],"drug-induced":[2],"locomotor":[3,71],"behavior":[4],"was":[5,91],"investigated":[6],"in":[7,109],"rats":[8],"subjected":[9],"to":[10,20,43,48,56,76,89,114],"lesions":[11],"of":[12,24,83,97,106],"the":[13,17,74,86,98],"ventral":[14,100],"striatum,":[15],"using":[16],"neurotoxin":[18],"6-hydroxydopamine":[19],"produce":[21],"selective":[22],"depletions":[23,105],"dopamine.":[25],"Locomotor":[26],"activity":[27,72],"changed":[28],"with":[29],"time":[30],"after":[31],"lesion.":[32],"At":[33],"2":[34],"weeks":[35,66],"postoperative":[36],"less":[37],"spontaneous":[38,70],"rearings":[39],"were":[40,62,78],"observed":[41,64],"compared":[42],"controls,":[44,84],"a":[45],"reduced":[46],"response":[47,55,75,88],"1.0":[49],"mg/kg":[50,58],"amphetamine":[51,77],"an":[53],"increased":[54],"0.1":[57],"apomorphine.":[59],"These":[60],"changes":[61],"not":[63,79],"9":[65],"postoperative;":[67],"that":[68],"is,":[69],"different":[80],"from":[81],"those":[82],"rearing":[87],"apomorphine":[90],"now":[92],"reduced.":[93],"The":[94],"neurochemical":[95],"assays":[96],"lesioned":[99],"striate":[101],"showed":[102],"equivalent":[103],"dopamine":[104],"about":[107],"48%":[108],"both":[110],"lesion":[111],"groups":[112],"relative":[113],"controls.":[115]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}