{"id":"https://openalex.org/W1969097828","doi":"https://doi.org/10.2165/00007256-199927030-00002","title":"Exercise-Induced Muscle Damage and Potential Mechanisms for the Repeated Bout Effect","display_name":"Exercise-Induced Muscle Damage and Potential Mechanisms for the Repeated Bout Effect","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1969097828","doi":"https://doi.org/10.2165/00007256-199927030-00002","mag":"1969097828","pmid":"https://pubmed.ncbi.nlm.nih.gov/10222539"},"language":"en","primary_location":{"id":"doi:10.2165/00007256-199927030-00002","doi":"https://doi.org/10.2165/00007256-199927030-00002","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00007256-199927030-00002","pdf_url":null,"source":{"id":"https://openalex.org/S137994755","display_name":"Sports Medicine","issn_l":"0112-1642","issn":["0112-1642","1179-2035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sports Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1969097828"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078398656","display_name":"Malachy P. McHugh","orcid":"https://orcid.org/0000-0002-8371-8151","observed_orcids":["https://orcid.org/0000-0002-8371-8151"]},"institutions":[{"id":"https://openalex.org/I161548249","display_name":"Bangor University","ror":"https://ror.org/006jb1a24","country_code":"GB","type":"education","lineage":["https://openalex.org/I161548249"]},{"id":"https://openalex.org/I2800628709","display_name":"Lenox Hill Hospital","ror":"https://ror.org/0231d2y50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800628709"]},{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Malachy P. McHugh","raw_affiliation_strings":["School of Sport, Health and Physical Education Sciences, University of Wales, Bangor, Gwynedd, Wales. mchugh@nismat.org","Lenox Hill Hospital","University of Wales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport, Health and Physical Education Sciences, University of Wales, Bangor, Gwynedd, Wales. mchugh@nismat.org","institution_ids":["https://openalex.org/I161548249"]},{"raw_affiliation_string":"Lenox Hill Hospital","institution_ids":["https://openalex.org/I2800628709"]},{"raw_affiliation_string":"University of Wales","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103552611","display_name":"Declan Connolly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Declan A.J. Connolly","raw_affiliation_strings":["Department of Physical Education, University of Vermont, Burlington, Vermont, USA","UNIVERSITY OF VERMONT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Education, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"UNIVERSITY OF VERMONT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020538327","display_name":"Roger G. Eston","orcid":"https://orcid.org/0000-0002-2680-7473","observed_orcids":["https://orcid.org/0000-0002-2680-7473"]},"institutions":[{"id":"https://openalex.org/I161548249","display_name":"Bangor University","ror":"https://ror.org/006jb1a24","country_code":"GB","type":"education","lineage":["https://openalex.org/I161548249"]},{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger G. Eston","raw_affiliation_strings":["School of Sport, Health and Physical Education Sciences, University of Wales, Bangor, Gwynedd Wales, UK","University of Wales"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport, Health and Physical Education Sciences, University of Wales, Bangor, Gwynedd Wales, UK","institution_ids":["https://openalex.org/I161548249"]},{"raw_affiliation_string":"University of Wales","institution_ids":["https://openalex.org/I97429440"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113777501","display_name":"Gilbert W. Gleim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800628709","display_name":"Lenox Hill Hospital","ror":"https://ror.org/0231d2y50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I2800628709"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert W. Gleim","raw_affiliation_strings":["Nicholas Institute of Sports Medicine and Athletic Trauma, Lenox Hill Hospital, New York, New York, USA","Lenox Hill Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nicholas Institute of Sports Medicine and Athletic Trauma, Lenox Hill Hospital, New York, New York, USA","institution_ids":["https://openalex.org/I2800628709"]},{"raw_affiliation_string":"Lenox Hill Hospital","institution_ids":["https://openalex.org/I2800628709"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078398656"],"corresponding_institution_ids":["https://openalex.org/I161548249","https://openalex.org/I2800628709","https://openalex.org/I97429440"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":6.7912,"has_fulltext":false,"cited_by_count":401,"citation_normalized_percentile":{"value":0.9749907,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"27","issue":"3","first_page":"157","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-induced-muscle-damage","display_name":"exercise-induced muscle damage","score":0.984000027179718},{"id":"https://openalex.org/keywords/repeated-bout-effect","display_name":"repeated bout effect","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eccentric-exercise","display_name":"eccentric exercise","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neural-adaptation","display_name":"neural adaptation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cellular-adaptation","display_name":"cellular adaptation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/motor-unit-activation","display_name":"motor unit activation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fast-twitch-fibres","display_name":"fast-twitch fibres","score":0.8349999785423279},{"id":"https://openalex.org/keywords/type-i-muscle-fibres","display_name":"type I muscle fibers","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.8209999799728394},{"id":"https://openalex.org/keywords/intramuscular-connective-tissue","display_name":"intramuscular connective tissue","score":0.8560000061988831},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.7626435160636902},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.7172237038612366},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.6612210273742676},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.5672000050544739},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.5452240109443665},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5250199437141418},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4981358051300049},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4562995135784149},{"id":"https://openalex.org/C2778470209","wikidata":"https://www.wikidata.org/wiki/Q5332180","display_name":"Eccentric exercise","level":3,"score":0.4274406135082245},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.3835849463939667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3498248755931854},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.320747971534729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3154498338699341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27666744589805603},{"id":"https://openalex.org/C2993817360","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle damage","level":2,"score":0.2623085677623749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23471897840499878},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.22722643613815308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11501088738441467},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07599747180938721},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012090","descriptor_name":"Cumulative Trauma Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012090","descriptor_name":"Cumulative Trauma Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012090","descriptor_name":"Cumulative Trauma Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015601","descriptor_name":"Injury Severity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/00007256-199927030-00002","doi":"https://doi.org/10.2165/00007256-199927030-00002","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00007256-199927030-00002","pdf_url":null,"source":{"id":"https://openalex.org/S137994755","display_name":"Sports Medicine","issn_l":"0112-1642","issn":["0112-1642","1179-2035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sports Medicine","raw_type":"journal-article"},{"id":"pmid:10222539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10222539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sports medicine (Auckland, N.Z.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W42368902","https://openalex.org/W152504266","https://openalex.org/W1569185166","https://openalex.org/W1822784999","https://openalex.org/W1844317142","https://openalex.org/W1885067579","https://openalex.org/W1899950345","https://openalex.org/W1916485854","https://openalex.org/W1964690048","https://openalex.org/W1965883224","https://openalex.org/W1967268428","https://openalex.org/W1969467903","https://openalex.org/W1971048512","https://openalex.org/W1975696220","https://openalex.org/W1979588184","https://openalex.org/W1982917710","https://openalex.org/W1985001010","https://openalex.org/W1987856003","https://openalex.org/W1988818325","https://openalex.org/W1989252098","https://openalex.org/W1994454932","https://openalex.org/W1997538280","https://openalex.org/W2005720779","https://openalex.org/W2006690236","https://openalex.org/W2006955286","https://openalex.org/W2022317304","https://openalex.org/W2026587229","https://openalex.org/W2028194205","https://openalex.org/W2033359534","https://openalex.org/W2033844681","https://openalex.org/W2038537781","https://openalex.org/W2040099865","https://openalex.org/W2040873398","https://openalex.org/W2043198132","https://openalex.org/W2044502834","https://openalex.org/W2046077945","https://openalex.org/W2047917359","https://openalex.org/W2049763849","https://openalex.org/W2053046908","https://openalex.org/W2065100252","https://openalex.org/W2076016842","https://openalex.org/W2076152791","https://openalex.org/W2084154823","https://openalex.org/W2087552631","https://openalex.org/W2088554031","https://openalex.org/W2091442600","https://openalex.org/W2104949288","https://openalex.org/W2110856852","https://openalex.org/W2115225161","https://openalex.org/W2117790407","https://openalex.org/W2135524939","https://openalex.org/W2135638650","https://openalex.org/W2136909562","https://openalex.org/W2139824469","https://openalex.org/W2141399230","https://openalex.org/W2147019512","https://openalex.org/W2147795459","https://openalex.org/W2152291661","https://openalex.org/W2158694936","https://openalex.org/W2161223977","https://openalex.org/W2163934771","https://openalex.org/W2166179150","https://openalex.org/W2168556034","https://openalex.org/W2169013317","https://openalex.org/W2169400659","https://openalex.org/W2173344933","https://openalex.org/W2178879833","https://openalex.org/W2180593742","https://openalex.org/W2226718330","https://openalex.org/W2251594913","https://openalex.org/W2266904413","https://openalex.org/W2269278230","https://openalex.org/W2288939976","https://openalex.org/W2320294958","https://openalex.org/W2399705667","https://openalex.org/W2410338206"],"related_works":["https://openalex.org/W2129525035","https://openalex.org/W1874567540","https://openalex.org/W1607894613","https://openalex.org/W2989636428","https://openalex.org/W2258657685","https://openalex.org/W2144915087","https://openalex.org/W2807908044","https://openalex.org/W2080393223","https://openalex.org/W1974566379","https://openalex.org/W2185183054"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
