{"id":"https://openalex.org/W1968981204","doi":"https://doi.org/10.1016/s0021-9673(97)00254-9","title":"Rigid porous polyacrylamide-based monolithic columns containing butyl methacrylate as a separation medium for the rapid hydrophobic interaction chromatography of proteins","display_name":"Rigid porous polyacrylamide-based monolithic columns containing butyl methacrylate as a separation medium for the rapid hydrophobic interaction chromatography of proteins","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1968981204","doi":"https://doi.org/10.1016/s0021-9673(97)00254-9","mag":"1968981204","pmid":"https://pubmed.ncbi.nlm.nih.gov/9253195"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9673(97)00254-9","doi":"https://doi.org/10.1016/s0021-9673(97)00254-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9673(97)00254-9","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967397002549/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021967397002549/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070992905","display_name":"Shaofeng Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaofeng Xie","raw_affiliation_strings":["Cornell University, Department of Chemistry, Baker Laboratory, Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University, Department of Chemistry, Baker Laboratory, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038193861","display_name":"Franti\u0161ek \u0160vec","orcid":"https://orcid.org/0000-0001-6574-1537","observed_orcids":["https://orcid.org/0000-0001-6574-1537"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frantisek Svec","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002152167","display_name":"Jean M. J. Fr\u00e9chet","orcid":"https://orcid.org/0000-0001-6419-0163","observed_orcids":["https://orcid.org/0000-0001-6419-0163"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean M.J Fr\u00e9chet","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002152167"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":2.0394,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.8417734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"775","issue":"1-2","first_page":"65","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.35989999771118164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13604","display_name":"Adsorption, diffusion, and thermodynamic properties of materials","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrophobic-interaction-chromatography","display_name":"hydrophobic interaction chromatography","score":0.9399999976158142},{"id":"https://openalex.org/keywords/protein-separation","display_name":"protein separation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/monolithic-columns","display_name":"monoliths","score":0.8700000047683716},{"id":"https://openalex.org/keywords/polyacrylamide","display_name":"polyacrylamide","score":0.6520000100135803},{"id":"https://openalex.org/keywords/butyl-methacrylate","display_name":"butyl methacrylate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/n-n-methylenebisacrylamide","display_name":"N,N'-methylenebisacrylamide","score":0.8690000176429749},{"id":"https://openalex.org/keywords/macroporous-polymers","display_name":"macroporous polymers","score":0.7269999980926514},{"id":"https://openalex.org/keywords/in-situ-polymerization","display_name":"in situ polymerization","score":0.625},{"id":"https://openalex.org/keywords/hplc-columns","display_name":"HPLC columns","score":0.6399999856948853},{"id":"https://openalex.org/keywords/back-pressure","display_name":"back pressure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/salt-effects","display_name":"salt effects","score":0.574999988079071},{"id":"https://openalex.org/keywords/recovery","display_name":"recovery","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9486356377601624},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.826223611831665},{"id":"https://openalex.org/C116817701","wikidata":"https://www.wikidata.org/wiki/Q5955221","display_name":"Hydrophilic interaction chromatography","level":3,"score":0.7192370891571045},{"id":"https://openalex.org/C2778862431","wikidata":"https://www.wikidata.org/wiki/Q416002","display_name":"Polyacrylamide","level":2,"score":0.6960890293121338},{"id":"https://openalex.org/C134871310","wikidata":"https://www.wikidata.org/wiki/Q6901686","display_name":"Monolithic HPLC column","level":3,"score":0.6510469913482666},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.6011662483215332},{"id":"https://openalex.org/C152815550","wikidata":"https://www.wikidata.org/wiki/Q653208","display_name":"Monolith","level":3,"score":0.45386433601379395},{"id":"https://openalex.org/C2989464291","wikidata":"https://www.wikidata.org/wiki/Q146123","display_name":"Polymethyl methacrylate","level":3,"score":0.4451250731945038},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.2683493494987488},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.22230884432792664},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1963592767715454},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18675115704536438},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.0990443229675293},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099166","descriptor_name":"Polyacrylamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9673(97)00254-9","doi":"https://doi.org/10.1016/s0021-9673(97)00254-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9673(97)00254-9","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967397002549/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:9253195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9253195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9673(97)00254-9","doi":"https://doi.org/10.1016/s0021-9673(97)00254-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9673(97)00254-9","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967397002549/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2556577972","display_name":"POROUS POLYMER RODS AS CHROMATOGRAPHIC OR REACTIVE MEDIA","funder_award_id":"R01GM048364","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4117707385","display_name":null,"funder_award_id":"GM48364","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968981204.pdf","grobid_xml":"https://content.openalex.org/works/W1968981204.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W996214182","https://openalex.org/W1492395515","https://openalex.org/W1557141846","https://openalex.org/W1967614917","https://openalex.org/W1967756794","https://openalex.org/W1976549108","https://openalex.org/W1985709914","https://openalex.org/W2002196405","https://openalex.org/W2004301649","https://openalex.org/W2006733040","https://openalex.org/W2015725637","https://openalex.org/W2017611602","https://openalex.org/W2021053177","https://openalex.org/W2028335230","https://openalex.org/W2031820094","https://openalex.org/W2039225156","https://openalex.org/W2039815518","https://openalex.org/W2046892424","https://openalex.org/W2061606846","https://openalex.org/W2071172293","https://openalex.org/W2089236282","https://openalex.org/W2123012409","https://openalex.org/W6733177642"],"related_works":["https://openalex.org/W1976436666","https://openalex.org/W2370198297","https://openalex.org/W1972353116","https://openalex.org/W2171818065","https://openalex.org/W2047234306","https://openalex.org/W2159737187","https://openalex.org/W380858747","https://openalex.org/W1981632922","https://openalex.org/W3217469745","https://openalex.org/W2068936131"],"abstract_inverted_index":{"Macroporous":[0],"poly(acrylamide-co-butyl":[1],"methacrylate-co-N,N'-methylenebisacrylamide)":[2],"monoliths":[3],"containing":[4],"up":[5],"to":[6],"15%":[7],"butyl":[8],"methacrylate":[9],"units":[10],"have":[11],"been":[12],"prepared":[13],"by":[14],"direct":[15],"polymerization":[16,51],"within":[17,84],"the":[18,50,58,76],"confines":[19],"of":[20,28,44,46,54,60,71],"HPLC":[21],"columns.":[22],"The":[23],"hydrodynamic":[24],"and":[25,65],"chromatographic":[26],"properties":[27],"these":[29],"50":[30],"mm":[31,34],"x":[32],"8":[33],"I.D.":[35],"columns-such":[36],"as":[37],"back":[38],"pressure":[39],"at":[40],"different":[41],"flow-rates,":[42],"effect":[43,53],"percentage":[45],"hydrophobic":[47,72],"component":[48],"in":[49],"mixture,":[52],"salt":[55],"concentration":[56],"on":[57],"retention":[59],"proteins,":[61],"dynamic":[62],"loading":[63],"capacity,":[64],"recovery-were":[66],"determined":[67],"under":[68],"conditions":[69],"typical":[70],"interaction":[73],"chromatography.":[74],"Using":[75],"monolithic":[77],"column,":[78],"five":[79],"proteins":[80],"were":[81],"easily":[82],"separated":[83],"only":[85],"3":[86],"min.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
