{"id":"https://openalex.org/W1968973248","doi":"https://doi.org/10.1523/jneurosci.4736-08.2009","title":"Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease","display_name":"Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease","publication_year":2009,"publication_date":"2009-07-22","ids":{"openalex":"https://openalex.org/W1968973248","doi":"https://doi.org/10.1523/jneurosci.4736-08.2009","mag":"1968973248","pmid":"https://pubmed.ncbi.nlm.nih.gov/19625522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3411546"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4736-08.2009","doi":"https://doi.org/10.1523/jneurosci.4736-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4736-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/29/9321.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/29/9321.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033385768","display_name":"Shiyong Peng","orcid":"https://orcid.org/0000-0003-0697-3674","observed_orcids":["https://orcid.org/0000-0003-0697-3674"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shiyong Peng","raw_affiliation_strings":["Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108348947","display_name":"Diego J. Garzon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Diego J. Garzon","raw_affiliation_strings":["Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","Bristol-Meyers Squibb","McMaster University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Bristol-Meyers Squibb","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"McMaster University","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103888056","display_name":"Monica Marchese","orcid":"https://orcid.org/0000-0002-0250-5331","observed_orcids":["https://orcid.org/0000-0002-0250-5331"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Monica Marchese","raw_affiliation_strings":["Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","McMaster university#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"McMaster university#TAB#","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054687151","display_name":"William L. Klein","orcid":"https://orcid.org/0000-0002-3047-9978","observed_orcids":["https://orcid.org/0000-0002-3047-9978"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Klein","raw_affiliation_strings":["Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208 ,","Institute for Neuroscience , Northwestern University , Evanston , Illinois 60611 ,","Neurobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology , Northwestern University , Evanston , Illinois 60208 ,","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Institute for Neuroscience , Northwestern University , Evanston , Illinois 60611 ,","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Neurobiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047993013","display_name":"Stephen D. Ginsberg","orcid":"https://orcid.org/0000-0002-1797-4288","observed_orcids":["https://orcid.org/0000-0002-1797-4288"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Ginsberg","raw_affiliation_strings":["Nathan Kline Institute , New York University School of Medicine , Orangeburg , New York 10962 ,","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan Kline Institute , New York University School of Medicine , Orangeburg , New York 10962 ,","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080169428","display_name":"Beverly M. Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Beverly M. Francis","raw_affiliation_strings":["Department of Physiology , University of Toronto , Toronto , Ontario M5S 1A8 , Canada,","Division of Neurology , Department of Medicine , University of Toronto , Toronto , Ontario M5S 3H2 , Canada,","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology , University of Toronto , Toronto , Ontario M5S 1A8 , Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Neurology , Department of Medicine , University of Toronto , Toronto , Ontario M5S 3H2 , Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074353247","display_name":"Howard T.J. Mount","orcid":"https://orcid.org/0000-0003-4666-0242","observed_orcids":["https://orcid.org/0000-0003-4666-0242"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Howard T. J. Mount","raw_affiliation_strings":["Department of Physiology , University of Toronto , Toronto , Ontario M5S 1A8 , Canada,","Division of Neurology , Department of Medicine , University of Toronto , Toronto , Ontario M5S 3H2 , Canada,","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology , University of Toronto , Toronto , Ontario M5S 1A8 , Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Neurology , Department of Medicine , University of Toronto , Toronto , Ontario M5S 3H2 , Canada,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072527270","display_name":"Elliott Jay Mufson","orcid":"https://orcid.org/0000-0003-4438-7334","observed_orcids":["https://orcid.org/0000-0003-4438-7334"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott J. Mufson","raw_affiliation_strings":["Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612","Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080159317","display_name":"Ahmad Salehi","orcid":"https://orcid.org/0000-0001-8257-3280","observed_orcids":["https://orcid.org/0000-0001-8257-3280"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Salehi","raw_affiliation_strings":["Department of Neurology , Stanford University , Stanford , California 94305","Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology , Stanford University , Stanford , California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043600072","display_name":"Margaret L. Fahnestock","orcid":"https://orcid.org/0000-0002-6815-0529","observed_orcids":["https://orcid.org/0000-0002-6815-0529"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Margaret Fahnestock","raw_affiliation_strings":["Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","McMaster university#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioural Neurosciences , McMaster University , Hamilton , Ontario L8N 3Z5 , Canada,","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"McMaster university#TAB#","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7403,"has_fulltext":true,"cited_by_count":224,"citation_normalized_percentile":{"value":0.97271203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"29","issue":"29","first_page":"9321","last_page":"9329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8999999761581421},{"id":"https://openalex.org/keywords/abeta42-40-ratio","display_name":"A\u03b242/A\u03b240 ratio","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8455135822296143},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.7602227330207825},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7483983039855957},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6813169121742249},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6435592174530029},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6179236173629761},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.6106554865837097},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5625036954879761},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5363135933876038},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4557196795940399},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4422224462032318},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4411178231239319},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4284043312072754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39392247796058655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.382149338722229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3795425295829773},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35276490449905396},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19941380620002747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18043404817581177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1490326225757599},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14104965329170227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09868934750556946},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058255","descriptor_name":"Protease Nexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.4736-08.2009","doi":"https://doi.org/10.1523/jneurosci.4736-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4736-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/29/9321.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2417237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3411546","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19625522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19625522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3411546","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3411546/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"mag:2184994919","doi":null,"is_oa":false,"landing_page_url":"http://www.jneurosci.org/content/29/29/9321.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4736-08.2009","doi":"https://doi.org/10.1523/jneurosci.4736-08.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4736-08.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/29/9321.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3711302076","display_name":"Neurobiology of Mild Cognitive Impairment in the Elderly","funder_award_id":"P01AG014449","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4368771867","display_name":"Pathological and Functional Impact of Tauopathy in vivo","funder_award_id":"P01NS048447","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4568863546","display_name":"Lesion Induced Synaptic Plasticity","funder_award_id":"R01NS043939","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6274562036","display_name":null,"funder_award_id":"AG10688","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6770541748","display_name":"Cellular and Molecular Medial Temporal Lobe Pathology in Elderly PreMCI subjects","funder_award_id":"R01AG043375","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8220790304","display_name":"Cell and Molecular Pathobiology of Alzheimer's Disease","funder_award_id":"P01AG017617","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8843512131","display_name":null,"funder_award_id":"85042","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320319910","display_name":"Scottish Rite Charitable Foundation of Canada","ror":"https://ror.org/02ts8v790"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968973248.pdf","grobid_xml":"https://content.openalex.org/works/W1968973248.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1556008598","https://openalex.org/W1637989849","https://openalex.org/W1651448739","https://openalex.org/W1677883125","https://openalex.org/W1747414752","https://openalex.org/W1747922801","https://openalex.org/W1855932518","https://openalex.org/W1963500709","https://openalex.org/W1966785609","https://openalex.org/W1967316112","https://openalex.org/W1969810313","https://openalex.org/W1971003242","https://openalex.org/W1979305117","https://openalex.org/W1979496428","https://openalex.org/W1980906872","https://openalex.org/W1981458288","https://openalex.org/W1982889157","https://openalex.org/W1987686583","https://openalex.org/W1992476409","https://openalex.org/W1992529363","https://openalex.org/W1993465897","https://openalex.org/W1995086580","https://openalex.org/W2001210466","https://openalex.org/W2001834310","https://openalex.org/W2002637584","https://openalex.org/W2008251385","https://openalex.org/W2014719301","https://openalex.org/W2034504333","https://openalex.org/W2039753950","https://openalex.org/W2040721710","https://openalex.org/W2047159816","https://openalex.org/W2055979394","https://openalex.org/W2060683202","https://openalex.org/W2062214806","https://openalex.org/W2066110504","https://openalex.org/W2069527370","https://openalex.org/W2070881916","https://openalex.org/W2071610467","https://openalex.org/W2071953900","https://openalex.org/W2072368655","https://openalex.org/W2073374252","https://openalex.org/W2073644964","https://openalex.org/W2074698464","https://openalex.org/W2075481535","https://openalex.org/W2078212921","https://openalex.org/W2079472132","https://openalex.org/W2081182167","https://openalex.org/W2084233122","https://openalex.org/W2086135754","https://openalex.org/W2087255758","https://openalex.org/W2089469670","https://openalex.org/W2090150925","https://openalex.org/W2095430905","https://openalex.org/W2096410114","https://openalex.org/W2097965815","https://openalex.org/W2099268443","https://openalex.org/W2108773796","https://openalex.org/W2116216781","https://openalex.org/W2127027544","https://openalex.org/W2130144581","https://openalex.org/W2130837565","https://openalex.org/W2133360097","https://openalex.org/W2133549393","https://openalex.org/W2133850147","https://openalex.org/W2135219890","https://openalex.org/W2142186280","https://openalex.org/W2145328569","https://openalex.org/W2145398673","https://openalex.org/W2146729934","https://openalex.org/W2150999725","https://openalex.org/W2151986987","https://openalex.org/W2153747061","https://openalex.org/W2163639252","https://openalex.org/W2164642027","https://openalex.org/W2164785427","https://openalex.org/W2165021720","https://openalex.org/W2255114932"],"related_works":["https://openalex.org/W2014719301","https://openalex.org/W2748549296","https://openalex.org/W2601817299","https://openalex.org/W2223300869","https://openalex.org/W2170013728","https://openalex.org/W2514934551","https://openalex.org/W2153913073","https://openalex.org/W7096967456","https://openalex.org/W1965318694","https://openalex.org/W7057055006"],"abstract_inverted_index":{"Downregulation":[0],"of":[1,14,44,83,108,112,172,197,205,216,224,240,253],"brain-derived":[2],"neurotrophic":[3],"factor":[4],"(BDNF)":[5],"in":[6,11,24,58,71,86,95,98,103,183,186],"the":[7,12,61,76,113,135,140,212,238,250],"cortex":[8],"occurs":[9],"early":[10],"progression":[13],"Alzheimer's":[15],"disease":[16],"(AD).":[17],"Since":[18],"BDNF":[19,31,56,84,126,173,206,231,245],"plays":[20],"a":[21,104,193],"critical":[22],"role":[23],"neuronal":[25],"survival,":[26],"synaptic":[27,36],"plasticity,":[28],"and":[29,37,40,102,120,150,159,176,203,214,226,256],"memory,":[30],"reduction":[32],"may":[33],"contribute":[34],"to":[35,55,249],"cellular":[38],"loss":[39],"memory":[41],"deficits":[42],"characteristic":[43],"AD.":[45,184],"In":[46,75],"vitro":[47],"evidence":[48],"suggests":[49],"that":[50,211,237],"amyloid-beta":[51],"(A":[52],"beta)":[53],"contributes":[54],"downregulation":[57,70,171],"AD,":[59],"but":[60],"specific":[62,248],"A":[63,99,115,155,162,200,217,241,254],"beta":[64,100,116,163,218,242,255],"aggregation":[65,251],"state":[66,252],"responsible":[67],"for":[68],"this":[69],"vivo":[72],"is":[73,180,247,257],"unknown.":[74],"present":[77],"study,":[78],"we":[79],"examined":[80],"cortical":[81,125],"levels":[82,128,196],"mRNA":[85,127],"three":[87,114],"different":[88],"transgenic":[89,117,188,221],"AD":[90,225],"mouse":[91,106,143,189,222],"models":[92,223],"harboring":[93],"mutations":[94],"APP":[96],"resulting":[97],"overproduction,":[101],"genetic":[105],"model":[107,144],"Down":[109,141],"syndrome.":[110],"Two":[111],"strains":[118],"(APP(NLh)":[119],"TgCRND8)":[121],"exhibited":[122,170],"significantly":[123],"decreased":[124,244],"compared":[129],"with":[130,230],"wild-type":[131],"mice,":[132],"whereas":[133],"neither":[134],"other":[136],"strain":[137],"(APP(swe)/PS-1)":[138],"nor":[139],"syndrome":[142],"(Ts65Dn)":[145],"was":[146,192],"affected.":[147],"Only":[148],"APP(NLh)":[149],"TgCRND8":[151,168],"mice":[152,169],"expressed":[153],"high":[154],"beta(42)/A":[156,201],"beta(40)":[157],"ratios":[158],"larger":[160],"SDS-stable":[161],"oligomers":[164],"(approximately":[165],"115":[166],"kDa).":[167],"transcripts":[174],"III":[175],"IV;":[177],"transcript":[178],"IV":[179],"also":[181,235],"downregulated":[182],"Furthermore,":[185],"all":[187],"strains,":[190],"there":[191],"correlation":[194],"between":[195],"large":[198,260],"oligomers,":[199],"beta(40),":[202],"severity":[204],"decrease.":[207],"These":[208,233],"data":[209],"show":[210],"amount":[213],"species":[215],"vary":[219],"among":[220],"are":[227],"negatively":[228],"correlated":[229],"levels.":[232],"findings":[234],"suggest":[236],"effect":[239],"on":[243,259],"expression":[246],"dependent":[258],"oligomers.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
