{"id":"https://openalex.org/W1968969423","doi":"https://doi.org/10.2217/bmm.10.12","title":"Neutrophil Gelatinase-Associated Lipocalin: A\u00c2\ufffd Promising Biomarker for Human Acute Kidney Injury","display_name":"Neutrophil Gelatinase-Associated Lipocalin: A\u00c2\ufffd Promising Biomarker for Human Acute Kidney Injury","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1968969423","doi":"https://doi.org/10.2217/bmm.10.12","mag":"1968969423","pmid":"https://pubmed.ncbi.nlm.nih.gov/20406069","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2893148"},"language":"en","primary_location":{"id":"doi:10.2217/bmm.10.12","doi":"https://doi.org/10.2217/bmm.10.12","is_oa":false,"landing_page_url":"https://doi.org/10.2217/bmm.10.12","pdf_url":null,"source":{"id":"https://openalex.org/S130557755","display_name":"Biomarkers in Medicine","issn_l":"1752-0363","issn":["1752-0363","1752-0371"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2893148","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029916378","display_name":"Prasad Devarajan","orcid":"https://orcid.org/0000-0002-7847-8552","observed_orcids":["https://orcid.org/0000-0002-7847-8552"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prasad Devarajan","raw_affiliation_strings":["Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229-3039, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229-3039, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029916378"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":2.5537,"has_fulltext":false,"cited_by_count":338,"citation_normalized_percentile":{"value":0.93693694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"4","issue":"2","first_page":"265","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9110000133514404},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8899999856948853},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/serum-creatinine-limitations","display_name":"serum creatinine limitations","score":0.699999988079071},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6899999976158142},{"id":"https://openalex.org/keywords/aki-prediction","display_name":"AKI prediction","score":0.6010000109672546},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/clinical-trial-monitoring","display_name":"clinical trial monitoring","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8990627527236938},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.8780708312988281},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8336267471313477},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.7935652136802673},{"id":"https://openalex.org/C2909801038","wikidata":"https://www.wikidata.org/wiki/Q18028489","display_name":"Neutrophil gelatinase-associated lipocalin","level":3,"score":0.7836616039276123},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5827881097793579},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4370957314968109},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.398441880941391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2217/bmm.10.12","doi":"https://doi.org/10.2217/bmm.10.12","is_oa":false,"landing_page_url":"https://doi.org/10.2217/bmm.10.12","pdf_url":null,"source":{"id":"https://openalex.org/S130557755","display_name":"Biomarkers in Medicine","issn_l":"1752-0363","issn":["1752-0363","1752-0371"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Medicine","raw_type":"journal-article"},{"id":"pmid:20406069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20406069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2893148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2893148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biomark Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2893148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2893148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biomark Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2078725536","display_name":"NGAL: A novel early biomarker of acute renal injury","funder_award_id":"R21DK070163","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3421575458","display_name":"Implications of the ASK1/JNK pathway in ARF","funder_award_id":"R01DK069749","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7813507511","display_name":"ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES","funder_award_id":"R01DK053289","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W41808191","https://openalex.org/W341650837","https://openalex.org/W1540734062","https://openalex.org/W1578948486","https://openalex.org/W1588950918","https://openalex.org/W1597457551","https://openalex.org/W1947143876","https://openalex.org/W1966293545","https://openalex.org/W1966415880","https://openalex.org/W1966511891","https://openalex.org/W1967237457","https://openalex.org/W1968853064","https://openalex.org/W1969498465","https://openalex.org/W1973013098","https://openalex.org/W1975565827","https://openalex.org/W1979646197","https://openalex.org/W1982758716","https://openalex.org/W1988848280","https://openalex.org/W1989835493","https://openalex.org/W1990589819","https://openalex.org/W1991240049","https://openalex.org/W1991742244","https://openalex.org/W1994708463","https://openalex.org/W1996020381","https://openalex.org/W2000347404","https://openalex.org/W2007193748","https://openalex.org/W2010668846","https://openalex.org/W2011250217","https://openalex.org/W2019526345","https://openalex.org/W2020593065","https://openalex.org/W2021146185","https://openalex.org/W2025071957","https://openalex.org/W2027657646","https://openalex.org/W2028933700","https://openalex.org/W2030333039","https://openalex.org/W2031963584","https://openalex.org/W2033623167","https://openalex.org/W2033917903","https://openalex.org/W2034603185","https://openalex.org/W2035397803","https://openalex.org/W2036124167","https://openalex.org/W2036681763","https://openalex.org/W2049504171","https://openalex.org/W2049597588","https://openalex.org/W2051270168","https://openalex.org/W2052962601","https://openalex.org/W2058350585","https://openalex.org/W2058400411","https://openalex.org/W2058616676","https://openalex.org/W2060761887","https://openalex.org/W2060988779","https://openalex.org/W2063166582","https://openalex.org/W2065859456","https://openalex.org/W2067199569","https://openalex.org/W2069724453","https://openalex.org/W2069911721","https://openalex.org/W2069994259","https://openalex.org/W2070068969","https://openalex.org/W2074692187","https://openalex.org/W2075252398","https://openalex.org/W2079250582","https://openalex.org/W2079599351","https://openalex.org/W2080535870","https://openalex.org/W2080577362","https://openalex.org/W2083483419","https://openalex.org/W2083578200","https://openalex.org/W2084485916","https://openalex.org/W2091698164","https://openalex.org/W2094401212","https://openalex.org/W2095952603","https://openalex.org/W2098587662","https://openalex.org/W2099339447","https://openalex.org/W2099623158","https://openalex.org/W2100727924","https://openalex.org/W2102265071","https://openalex.org/W2109128578","https://openalex.org/W2109531898","https://openalex.org/W2110639401","https://openalex.org/W2116802079","https://openalex.org/W2116803132","https://openalex.org/W2122934045","https://openalex.org/W2127477439","https://openalex.org/W2127885325","https://openalex.org/W2129326184","https://openalex.org/W2129967807","https://openalex.org/W2130816048","https://openalex.org/W2131845214","https://openalex.org/W2131992237","https://openalex.org/W2133482423","https://openalex.org/W2136066292","https://openalex.org/W2136438262","https://openalex.org/W2139937737","https://openalex.org/W2140374361","https://openalex.org/W2141341148","https://openalex.org/W2143262001","https://openalex.org/W2143569590","https://openalex.org/W2144158251","https://openalex.org/W2145339507","https://openalex.org/W2147648931","https://openalex.org/W2148409083","https://openalex.org/W2149687213","https://openalex.org/W2150952999","https://openalex.org/W2154145185","https://openalex.org/W2155250786","https://openalex.org/W2155441599","https://openalex.org/W2156168206","https://openalex.org/W2156595883","https://openalex.org/W2157105773","https://openalex.org/W2159098568","https://openalex.org/W2160054854","https://openalex.org/W2160276873","https://openalex.org/W2160691052","https://openalex.org/W2161626134","https://openalex.org/W2164530605","https://openalex.org/W2164965999","https://openalex.org/W2165088763","https://openalex.org/W2166814458","https://openalex.org/W2170433159","https://openalex.org/W2171344771","https://openalex.org/W2415244809","https://openalex.org/W2487311963"],"related_works":["https://openalex.org/W1971034878","https://openalex.org/W2125387106","https://openalex.org/W2501347149","https://openalex.org/W1997758474","https://openalex.org/W1667281349","https://openalex.org/W3090493684","https://openalex.org/W2408979221","https://openalex.org/W1985518230","https://openalex.org/W7100987372","https://openalex.org/W42353005"],"abstract_inverted_index":{"Acute":[0],"kidney":[1,54],"injury":[2],"(AKI)":[3],"is":[4,21,89],"a":[5,22,60],"common":[6,120],"and":[7,24,68,100,112],"serious":[8],"condition,":[9],"the":[10,48,53,75,98,103,114],"diagnosis":[11],"of":[12,27,31,52,62,70,105,116],"which":[13],"depends":[14],"on":[15],"serum":[16],"creatinine":[17,20],"measurements.":[18],"Unfortunately,":[19],"delayed":[23],"unreliable":[25],"indicator":[26],"AKI.":[28,45],"The":[29,65],"lack":[30],"early":[32,49],"biomarkers":[33],"has":[34,58],"crippled":[35],"our":[36],"ability":[37],"to":[38,43,55],"translate":[39],"promising":[40,77],"experimental":[41],"therapies":[42],"human":[44],"Fortunately,":[46],"understanding":[47],"stress":[50],"response":[51],"acute":[56],"injuries":[57],"revealed":[59],"number":[61],"potential":[63],"biomarkers.":[64],"discovery,":[66],"translation":[67],"validation":[69],"neutrophil":[71],"gelatinase-associated":[72,87],"lipocalin,":[73],"arguably":[74],"most":[76],"novel":[78],"AKI":[79,111,117],"biomarker,":[80],"are":[81],"reviewed":[82],"in":[83,97,110,118],"this":[84],"article.":[85],"Neutrophil":[86],"lipocalin":[88],"emerging":[90],"as":[91],"an":[92],"excellent":[93],"standalone":[94],"troponin-like":[95],"biomarker":[96],"plasma":[99],"urine":[101],"for":[102,113],"prediction":[104],"AKI,":[106],"monitoring":[107],"clinical":[108,121],"trials":[109],"prognosis":[115],"several":[119],"scenarios.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}