{"id":"https://openalex.org/W1968955229","doi":"https://doi.org/10.1371/journal.pone.0003331","title":"The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel \u2018Alarmin\u2019?","display_name":"The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel \u2018Alarmin\u2019?","publication_year":2008,"publication_date":"2008-10-03","ids":{"openalex":"https://openalex.org/W1968955229","doi":"https://doi.org/10.1371/journal.pone.0003331","mag":"1968955229","pmid":"https://pubmed.ncbi.nlm.nih.gov/18836528","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2556082"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0003331","doi":"https://doi.org/10.1371/journal.pone.0003331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0003331","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003331&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003331&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011060693","display_name":"Christine Moussion","orcid":"https://orcid.org/0000-0002-1641-4094","observed_orcids":["https://orcid.org/0000-0002-1641-4094"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Moussion","raw_affiliation_strings":["CNRS, Institute of Pharmacology and Structural Biology, Toulouse, France","CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","University of Toulouse, UPS, IPBS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Institute of Pharmacology and Structural Biology, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]},{"raw_affiliation_string":"CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]},{"raw_affiliation_string":"University of Toulouse, UPS, IPBS, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026809634","display_name":"Nathalie Ort\u00e9ga","orcid":"https://orcid.org/0009-0006-9969-9748","observed_orcids":["https://orcid.org/0009-0006-9969-9748"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Ortega","raw_affiliation_strings":["CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","University of Toulouse, UPS, IPBS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]},{"raw_affiliation_string":"University of Toulouse, UPS, IPBS, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064398262","display_name":"Jean\u2010Philippe Girard","orcid":"https://orcid.org/0000-0002-9154-1691","observed_orcids":["https://orcid.org/0000-0002-9154-1691"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Philippe Girard","raw_affiliation_strings":["CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","University of Toulouse, UPS, IPBS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, IPBS (Institute of Pharmacology and Structural Biology), Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099749"]},{"raw_affiliation_string":"University of Toulouse, UPS, IPBS, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064398262"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210099749","https://openalex.org/I4405258862"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":16.6017,"has_fulltext":true,"cited_by_count":1216,"citation_normalized_percentile":{"value":0.99538431,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"10","first_page":"e3331","last_page":"e3331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nuclear-expression","display_name":"nuclear expression","score":0.5130000114440918},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alarmins","display_name":"alarmins","score":0.8500000238418579},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.7279999852180481},{"id":"https://openalex.org/keywords/st2","display_name":"ST2","score":0.6990000009536743},{"id":"https://openalex.org/keywords/high-endothelial-venules","display_name":"high endothelial venules","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fibroblastic-reticular-cells","display_name":"fibroblastic reticular cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.5910000205039978},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C122862929","wikidata":"https://www.wikidata.org/wiki/Q18048437","display_name":"Interleukin 33","level":4,"score":0.8140796422958374},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6843876242637634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6775360703468323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46705877780914307},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.45386528968811035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4244823455810547},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.3268316388130188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.287598192691803},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08902758359909058}],"mesh":[{"descriptor_ui":"D000067596","descriptor_name":"Interleukin-33","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003893","descriptor_name":"Desmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0003331","doi":"https://doi.org/10.1371/journal.pone.0003331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0003331","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003331&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2556082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2556082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:18836528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18836528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.8465","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.8465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/de/0a/PLoS_ONE_2008_Oct_6_3(10)_e3331.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.406.6063","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.406.6063","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tissuearray.petagen.com/main/References/PLoS(2008)-ISU.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e7a9ad8aeb484b468981bc17a88e145e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e7a9ad8aeb484b468981bc17a88e145e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 3, Iss 10, p e3331 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0003331","doi":"https://doi.org/10.1371/journal.pone.0003331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0003331","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003331&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968955229.pdf","grobid_xml":"https://content.openalex.org/works/W1968955229.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W194792082","https://openalex.org/W1505584712","https://openalex.org/W1515994079","https://openalex.org/W1599815975","https://openalex.org/W1966991400","https://openalex.org/W1975438745","https://openalex.org/W1980215718","https://openalex.org/W1987582894","https://openalex.org/W1993954065","https://openalex.org/W1994190235","https://openalex.org/W1994391038","https://openalex.org/W1996775001","https://openalex.org/W2004266769","https://openalex.org/W2004992613","https://openalex.org/W2007221590","https://openalex.org/W2007810913","https://openalex.org/W2016193552","https://openalex.org/W2018653121","https://openalex.org/W2029068688","https://openalex.org/W2038344494","https://openalex.org/W2040470785","https://openalex.org/W2043033149","https://openalex.org/W2043099698","https://openalex.org/W2048813343","https://openalex.org/W2049398130","https://openalex.org/W2050267061","https://openalex.org/W2050488981","https://openalex.org/W2050601356","https://openalex.org/W2068044260","https://openalex.org/W2081487051","https://openalex.org/W2084671075","https://openalex.org/W2086460209","https://openalex.org/W2093396768","https://openalex.org/W2108283718","https://openalex.org/W2121686426","https://openalex.org/W2150594596","https://openalex.org/W2157710399","https://openalex.org/W2162803006","https://openalex.org/W2164396254","https://openalex.org/W2164714222","https://openalex.org/W2165239282","https://openalex.org/W2166623795","https://openalex.org/W2168381900"],"related_works":["https://openalex.org/W7095785981","https://openalex.org/W7095858954","https://openalex.org/W2116135404","https://openalex.org/W2093396768","https://openalex.org/W2029214638","https://openalex.org/W2057190795","https://openalex.org/W2779261498","https://openalex.org/W2528879414","https://openalex.org/W2330186959","https://openalex.org/W2070004290"],"abstract_inverted_index":{"BACKGROUND:":[0],"Interleukin-33":[1],"(IL-33)":[2],"is":[3,88,107,133,227],"an":[4,268],"IL-1-like":[5],"cytokine":[6,64,72],"ligand":[7],"for":[8],"the":[9,78,92,139,144,201,210,263,274],"IL-1":[10],"receptor-related":[11],"protein":[12],"ST2,":[13],"that":[14,47,105,131,238,257],"activates":[15],"mast":[16],"cells":[17,156,190,196,208,240,243],"and":[18,21,51,62,73,109,123,126,160,194,206,214,241],"Th2":[19],"lymphocytes,":[20],"induces":[22],"production":[23],"of":[24,80,95,119,138,152,185,191,197,209,247],"Th2-associated":[25],"cytokines":[26],"in":[27,40,98,112,154,164,172,187,230,249],"vivo.":[28,99,250],"We":[29,147],"initially":[30],"discovered":[31],"IL-33":[32,66,82,97,106,124,132,153,186,226,248,258],"as":[33,69,169,171,267],"a":[34,71,74,117,134],"nuclear":[35,75,136,150,183],"factor":[36],"(NF-HEV)":[37],"abundantly":[38,110],"expressed":[39,111,142,229],"high":[41],"endothelial":[42,155,239,278],"venules":[43],"from":[44,157],"lymphoid":[45,192],"organs,":[46],"associates":[48],"with":[49],"chromatin":[50],"exhibits":[52],"transcriptional":[53],"regulatory":[54],"properties.":[55],"This":[56],"suggested":[57],"that,":[58,222],"similarly":[59,261],"to":[60,177,200,262,272],"IL-1alpha":[61],"chromatin-associated":[63],"HMGB1,":[65,266],"may":[67,259],"act":[68],"both":[70,158],"factor.":[76],"Although":[77],"activity":[79],"recombinant":[81],"has":[83],"been":[84],"well":[85,170],"characterized,":[86],"little":[87],"known":[89],"yet":[90],"about":[91],"expression":[93,151,184],"pattern":[94],"endogenous":[96,269],"METHODOLOGY/PRINCIPAL":[100],"FINDINGS:":[101],"Here,":[102],"we":[103,129,179,255],"show":[104],"constitutively":[108,228],"normal":[113,166,231],"human":[114,120,167,173,232],"tissues.":[115,233],"Using":[116],"combination":[118],"tissue":[121],"microarrays":[122],"monoclonal":[125],"polyclonal":[127],"antibodies,":[128],"found":[130,181],"novel":[135],"marker":[137],"endothelium":[140],"widely":[141],"along":[143],"vascular":[145],"tree.":[146],"observed":[148],"abundant":[149],"large":[159],"small":[161],"blood":[162],"vessels":[163],"most":[165],"tissues,":[168,193],"tumors.":[174],"In":[175,234],"addition":[176],"endothelium,":[178],"also":[180],"constitutive":[182],"fibroblastic":[188],"reticular":[189],"epithelial":[195,207,242,280],"tissues":[198],"exposed":[199],"environment,":[202],"including":[203],"skin":[204],"keratinocytes":[205],"stomach,":[211],"tonsillar":[212],"crypts":[213],"salivary":[215],"glands.":[216],"CONCLUSIONS/SIGNIFICANCE:":[217],"Together,":[218],"our":[219],"results":[220],"indicate":[221],"unlike":[223],"inducible":[224],"cytokines,":[225],"addition,":[235],"they":[236],"reveal":[237],"constitute":[244],"major":[245],"sources":[246],"Based":[251],"on":[252],"these":[253],"findings,":[254],"speculate":[256],"function,":[260],"prototype":[264],"'alarmin'":[265],"'danger'":[270],"signal":[271],"alert":[273],"immune":[275],"system":[276],"after":[277],"or":[279,285],"cell":[281],"damage":[282],"during":[283],"trauma":[284],"infection.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":48},{"year":2023,"cited_by_count":62},{"year":2022,"cited_by_count":78},{"year":2021,"cited_by_count":84},{"year":2020,"cited_by_count":81},{"year":2019,"cited_by_count":73},{"year":2018,"cited_by_count":87},{"year":2017,"cited_by_count":86},{"year":2016,"cited_by_count":89},{"year":2015,"cited_by_count":89},{"year":2014,"cited_by_count":81},{"year":2013,"cited_by_count":78},{"year":2012,"cited_by_count":77}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
