{"id":"https://openalex.org/W1968900809","doi":"https://doi.org/10.1021/bc980034k","title":"Delivery of Antisense Oligonucleotides Using HPMA Polymer: Synthesis of A Thiol Polymer and Its Conjugation to Water-Soluble Molecules","display_name":"Delivery of Antisense Oligonucleotides Using HPMA Polymer: Synthesis of A Thiol Polymer and Its Conjugation to Water-Soluble Molecules","publication_year":1998,"publication_date":"1998-10-24","ids":{"openalex":"https://openalex.org/W1968900809","doi":"https://doi.org/10.1021/bc980034k","mag":"1968900809","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815169"},"language":"en","primary_location":{"id":"doi:10.1021/bc980034k","doi":"https://doi.org/10.1021/bc980034k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc980034k","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076731050","display_name":"Laixin Wang","orcid":"https://orcid.org/0000-0002-8850-3782","observed_orcids":["https://orcid.org/0000-0002-8850-3782"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laixin Wang","raw_affiliation_strings":["University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108","University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113909955","display_name":"Jakob Kristensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakob Kristensen","raw_affiliation_strings":["University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026648557","display_name":"Duane E. Ruffner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Duane E. Ruffner","raw_affiliation_strings":["University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 421 Wakara Way, Suite 318 Salt Lake City, Utah 84108","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026648557"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4844,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.55421863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"749","last_page":"757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9340000152587891},{"id":"https://openalex.org/keywords/thiol-terminated-polymers","display_name":"thiol-terminated polymers","score":0.7540000081062317},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5410000085830688},{"id":"https://openalex.org/keywords/water-soluble-drugs","display_name":"water-soluble drugs","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ligand-conjugation","display_name":"ligand conjugation","score":0.765999972820282},{"id":"https://openalex.org/keywords/amine-functionalized-polymers","display_name":"amine-functionalized polymers","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.900748074054718},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.8276245594024658},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.8234654664993286},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.7836486101150513},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7502394914627075},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.7162383794784546},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5902550220489502},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.530754804611206},{"id":"https://openalex.org/C2910051704","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide Linkage","level":4,"score":0.4618678689002991},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.45887553691864014},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.41353243589401245},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.4038131833076477},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28626549243927},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.21016836166381836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18427243828773499},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15409821271896362},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bc980034k","doi":"https://doi.org/10.1021/bc980034k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc980034k","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:9815169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7830359204","display_name":"RIBOZYMES--TARGET SITE SELECTION AND DRUG DELIVERY","funder_award_id":"R29AI034278","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895596","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310050","display_name":"University of Utah","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1526100164","https://openalex.org/W1535486835","https://openalex.org/W1562062833","https://openalex.org/W1584683177","https://openalex.org/W1603645835","https://openalex.org/W1773975057","https://openalex.org/W1972678792","https://openalex.org/W1977029770","https://openalex.org/W1979851400","https://openalex.org/W1991456836","https://openalex.org/W1996701312","https://openalex.org/W2003763258","https://openalex.org/W2006370393","https://openalex.org/W2036474910","https://openalex.org/W2041452578","https://openalex.org/W2066925054","https://openalex.org/W2078433042","https://openalex.org/W2081796018","https://openalex.org/W2151142281","https://openalex.org/W2312847415","https://openalex.org/W4245516850"],"related_works":["https://openalex.org/W2099574942","https://openalex.org/W2091095917","https://openalex.org/W1988918180","https://openalex.org/W3152308892","https://openalex.org/W2347125816","https://openalex.org/W2004569224","https://openalex.org/W2038504278","https://openalex.org/W6940568210","https://openalex.org/W2410014644","https://openalex.org/W3136536534"],"abstract_inverted_index":{"Here,":[0],"we":[1],"report":[2],"the":[3,17,49,54,66,82],"synthesis":[4],"and":[5,78],"characterization":[6],"of":[7,19,30,56,63],"an":[8],"HPMA-based":[9],"polymer":[10,24,37],"for":[11,16,28],"use":[12,55],"as":[13],"a":[14,33,61,71],"carrier":[15],"delivery":[18],"water":[20],"soluble":[21],"drugs.":[22],"The":[23,36,84],"contains":[25],"active-sulfhydryl":[26,50],"groups":[27,45],"coupling":[29],"ligands":[31,64],"through":[32],"disulfide":[34],"linkage.":[35],"can":[38,75],"also":[39],"be":[40,76],"prepared":[41],"containing":[42],"pendant":[43],"amino":[44],"in":[46],"addition":[47],"to":[48,59,65,81],"moiety.":[51],"This":[52],"allows":[53],"different":[57],"chemistries":[58],"conjugate":[60,86],"variety":[62],"polymer.":[67,83],"We":[68],"demonstrate":[69],"that":[70],"sulfhydryl-terminated":[72],"antisense":[73],"oligonucleotide":[74],"efficiently":[77,88],"rapidly":[79],"conjugated":[80],"polymer-oligonucleotide":[85],"is":[87],"taken":[89],"up":[90],"by":[91],"cultured":[92],"cells.":[93]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}