{"id":"https://openalex.org/W1968897950","doi":"https://doi.org/10.4161/cc.10.14.15917","title":"Bid as a potential target of apoptotic effects exerted by low doses of PPAR\u03b3 and RXR ligands in breast cancer cells","display_name":"Bid as a potential target of apoptotic effects exerted by low doses of PPAR\u03b3 and RXR ligands in breast cancer cells","publication_year":2011,"publication_date":"2011-07-15","ids":{"openalex":"https://openalex.org/W1968897950","doi":"https://doi.org/10.4161/cc.10.14.15917","mag":"1968897950","pmid":"https://pubmed.ncbi.nlm.nih.gov/21654191"},"language":"en","primary_location":{"id":"doi:10.4161/cc.10.14.15917","doi":"https://doi.org/10.4161/cc.10.14.15917","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.10.14.15917","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.10.14.15917?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.10.14.15917?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054597220","display_name":"Daniela Bonofiglio","orcid":"https://orcid.org/0000-0002-4142-0496","observed_orcids":["https://orcid.org/0000-0002-4142-0496"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Bonofiglio","raw_affiliation_strings":["Department of Pharmaco-Biology, Centro Sanitario, Faculty of Pharmacy Nutritional and Health Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaco-Biology, Centro Sanitario, Faculty of Pharmacy Nutritional and Health Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003329578","display_name":"Erika Cione","orcid":"https://orcid.org/0000-0002-0562-0597","observed_orcids":["https://orcid.org/0000-0002-0562-0597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Cione","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110775660","display_name":"Donatella Vizza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donatella Vizza","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112197833","display_name":"Mariarita Perri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariarita Perri","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073067607","display_name":"Attilio Pingitore","orcid":"https://orcid.org/0000-0002-1194-4280","observed_orcids":["https://orcid.org/0000-0002-1194-4280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Attilio Pingitore","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013562958","display_name":"Hongyan Qi","orcid":"https://orcid.org/0000-0002-4639-299X","observed_orcids":["https://orcid.org/0000-0002-4639-299X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyan Qi","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013221500","display_name":"Stefania Catalano","orcid":"https://orcid.org/0000-0002-6352-9628","observed_orcids":["https://orcid.org/0000-0002-6352-9628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Catalano","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002590489","display_name":"Daniela Rovito","orcid":"https://orcid.org/0000-0001-5390-5477","observed_orcids":["https://orcid.org/0000-0001-5390-5477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Rovito","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036500264","display_name":"Giuseppe Genchi","orcid":"https://orcid.org/0000-0003-0538-4907","observed_orcids":["https://orcid.org/0000-0003-0538-4907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Genchi","raw_affiliation_strings":["Department of pharmaco-Biology ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaco-Biology ;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102010816","display_name":"Sebastiano And\u00f2","orcid":"https://orcid.org/0000-0002-5412-7045","observed_orcids":["https://orcid.org/0000-0002-5412-7045"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sebastiano And\u00f2","raw_affiliation_strings":["Department of Cellular Biology ;","Faculty of pharmacy Nutritional and Health Sciences ; University of Calabria ; Cosenza , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology ;","institution_ids":[]},{"raw_affiliation_string":"Faculty of pharmacy Nutritional and Health Sciences ; University of Calabria ; Cosenza , Italy","institution_ids":["https://openalex.org/I45204951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102010816"],"corresponding_institution_ids":["https://openalex.org/I45204951"],"apc_list":null,"apc_paid":null,"fwci":0.963,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.70971199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"14","first_page":"2344","last_page":"2354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7639999985694885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/ppargamma-ligands","display_name":"PPAR\u03b3 ligands","score":0.9620000123977661},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/9-cis-retinoic-acid","display_name":"9-cis-retinoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-p53","display_name":"mitochondrial p53","score":0.5839999914169312},{"id":"https://openalex.org/keywords/truncated-bid","display_name":"truncated Bid","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9129999876022339},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9129999876022339},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8389999866485596},{"id":"https://openalex.org/keywords/p53-independent-apoptosis","display_name":"p53-independent apoptosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.6327438950538635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6310831308364868},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6166964173316956},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5541988015174866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212008357048035},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49634653329849243},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4723093509674072},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46716487407684326},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44273319840431213},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41068658232688904},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3314831256866455},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2704557776451111},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.2641358971595764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2550065517425537},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2328270673751831},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.057664573192596436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077556","descriptor_name":"Alitretinoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.10.14.15917","doi":"https://doi.org/10.4161/cc.10.14.15917","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.10.14.15917","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.10.14.15917?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:21654191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21654191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/125611","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11770/125611","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4161/cc.10.14.15917","doi":"https://doi.org/10.4161/cc.10.14.15917","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.10.14.15917","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.10.14.15917?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968897950.pdf","grobid_xml":"https://content.openalex.org/works/W1968897950.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3167636940","https://openalex.org/W2040920295","https://openalex.org/W7216649423","https://openalex.org/W7217119369","https://openalex.org/W2049231891","https://openalex.org/W1964170925","https://openalex.org/W2035539313","https://openalex.org/W7216927880","https://openalex.org/W2539242097","https://openalex.org/W7217270643"],"abstract_inverted_index":{"The":[0],"combined":[1],"treatment":[2],"with":[3],"nanomolar":[4],"doses":[5,194],"of":[6,63,71,115,121,127,159,164,180,195],"the":[7,13,51,75,85,90,92,95,104,113,119,125,157,162,178,184,207],"PPAR\u03b3":[8,55,137,196],"ligand":[9,15,86],"Rosiglitazone":[10],"(BRL)":[11],"and":[12,26,42,56,82,110,124,138,197],"RXR":[14,57,139,198],"9-cis\u2011retinoic":[16],"acid":[17],"(9RA)":[18],"induces":[19],"a":[20,36,100,203],"p53-dependent":[21],"apoptosis":[22,191],"in":[23,79,89,103,161,186,206],"MCF7,":[24],"SKBR3":[25,41],"T47D":[27,43],"human":[28],"breast":[29,188,212],"cancer":[30,189],"cells.":[31],"Since":[32],"MCF7":[33],"cells":[34,44,129],"express":[35],"wild-type":[37],"p53":[38,64],"protein,":[39],"while":[40],"harbor":[45],"endogenous":[46],"mutant":[47],"p53,":[48],"we":[49],"elucidated":[50],"mechanism":[52],"through":[53],"which":[54,148],"ligands":[58,140],"triggered":[59],"apoptotic":[60,105],"processes":[61],"independently":[62],"transcriptional":[65],"activity.":[66,171],"We":[67],"showed":[68],"an":[69],"upregulation":[70],"Bid":[72,97,154,160,201],"expression":[73],"enhancing":[74],"association":[76],"between":[77],"Bid/p53":[78],"both":[80],"cytosol":[81],"mitochondria":[83,185],"after":[84,132],"treatment.":[87],"Particularly":[88],"mitochondria,":[91],"complex":[93,182],"involves":[94],"truncated":[96],"that":[98],"plays":[99],"key":[101],"role":[102,179],"process":[106],"induced":[107],"by":[108],"BRL":[109],"9RA,":[111],"since":[112],"disruption":[114],"mitochondrial":[116,145,165],"membrane":[117],"potential,":[118],"induction":[120],"PARP":[122],"cleavage":[123],"percentage":[126],"TUNEL-positive":[128],"were":[130,141],"reversed":[131],"knocking":[133],"down":[134],"Bid.":[135],"Moreover,":[136],"able":[142],"to":[143],"reduce":[144],"GST":[146],"activity,":[147],"was":[149],"no":[150],"longer":[151],"noticeable":[152],"silencing":[153],"expression,":[155],"suggesting":[156],"potential":[158,204],"regulation":[163],"intracellular":[166],"reactive":[167],"oxygen":[168],"species":[169],"scavenger":[170],"Our":[172],"data,":[173],"providing":[174],"new":[175],"insight":[176],"into":[177],"p53/Bid":[181],"at":[183],"promoting":[187],"cell":[190],"upon":[192],"low":[193],"ligands,":[199],"address":[200],"as":[202],"target":[205],"novel":[208],"therapeutical":[209],"strategies":[210],"for":[211],"cancer.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
